Search Results - "KOLCH, Walter"

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity by Lee, Shannon, Rauch, Jens, Kolch, Walter

“…Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered…”
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The dynamic control of signal transduction networks in cancer cells by Kolch, Walter, Halasz, Melinda, Granovskaya, Marina, Kholodenko, Boris N.

“…Key Points Signal transduction networks (STNs) regulate fundamental biological processes by integrating and computing external and internal signals to adjust…”
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Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles by Rauch, Jens, Kolch, Walter, Laurent, Sophie, Mahmoudi, Morteza

“…Rauch et al examine the regulation of cell signaling pathways by nanoparticles…”
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From oncogenic mutation to dynamic code by Kolch, Walter, Kiel, Christina

“…Oncogenic BRAF mutations can distort downstream signaling outcomes Signal transduction pathways (STPs) convert biochemical reactions into precise and…”
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KBoost: a new method to infer gene regulatory networks from gene expression data by Iglesias-Martinez, Luis F., De Kegel, Barbara, Kolch, Walter

“…Reconstructing gene regulatory networks is crucial to understand biological processes and holds potential for developing personalized treatment. Yet, it is…”
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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions by Kolch, W

“…The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-regulated kinase) pathway is at the heart of signalling networks that…”
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Computational approaches for analyzing information flow in biological networks by Kholodenko, Boris, Yaffe, Michael B, Kolch, Walter

“…The advancements in "omics" (proteomics, genomics, lipidomics, and metabolomics) technologies have yielded large inventories of genes, transcripts, proteins,…”
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Evaluating strategies to normalise biological replicates of Western blot data by Degasperi, Andrea, Birtwistle, Marc R, Volinsky, Natalia, Rauch, Jens, Kolch, Walter, Kholodenko, Boris N

“…Western blot data are widely used in quantitative applications such as statistical testing and mathematical modelling. To ensure accurate quantitation and…”
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The Ins and Outs of RAS Effector Complexes by Kiel, Christina, Matallanas, David, Kolch, Walter

“…RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation,…”
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Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration by Bolado-Carrancio, Alfonso, Rukhlenko, Oleksii S, Nikonova, Elena, Tsyganov, Mikhail A, Wheeler, Anne, Garcia-Munoz, Amaya, Kolch, Walter, von Kriegsheim, Alex, Kholodenko, Boris N

“…Migrating cells need to coordinate distinct leading and trailing edge dynamics but the underlying mechanisms are unclear. Here, we combine experiments and…”
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The secret life of kinases: functions beyond catalysis by Rauch, Jens, Volinsky, Natalia, Romano, David, Kolch, Walter

“…Protein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However,…”
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Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation by Charitou, Theodosia, Srihari, Sriganesh, Lynn, Miriam A., Jarboui, Mohamed-Ali, Fasterius, Erik, Moldovan, Max, Shirasawa, Senji, Tsunoda, Toshiyuki, Ueffing, Marius, Xie, Jianling, Xin, Jin, Wang, Xuemin, Proud, Christopher G., Boldt, Karsten, Al-Khalili Szigyarto, Cristina, Kolch, Walter, Lynn, David J.

“…Background Activating mutations in KRAS frequently occur in colorectal cancer (CRC) patients, leading to resistance to EGFR-targeted therapies. Methods To…”
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Cell fate decisions are specified by the dynamic ERK interactome by Kalna, Gabriella, Baiocchi, Daniela, Orton, Richard, Birtwistle, Marc, Yamada, Kayo, von Kriegsheim, Alex, Morrice, Nicholas, Sumpton, David, Bienvenut, Willy, Kolch, Walter, Gilbert, David, Lamond, Angus

“…Extracellular signal-regulated kinase (ERK) controls fundamental cellular functions, including cell fate decisions. In PC12, cells shifting ERK activation from…”
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Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients by Fey, Dirk, Halasz, Melinda, Dreidax, Daniel, Kennedy, Sean P, Hastings, Jordan F, Rauch, Nora, Munoz, Amaya Garcia, Pilkington, Ruth, Fischer, Matthias, Westermann, Frank, Kolch, Walter, Kholodenko, Boris N, Croucher, David R

“…Signaling pathways control cell fate decisions that ultimately determine the behavior of cancer cells. Therefore, the dynamics of pathway activity may contain…”
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Role of the Kinase MST2 in Suppression of Apoptosis by the Proto-Oncogene Product Raf-1 by O'Neill, Eric, Rushworth, Linda, Baccarini, Manuela, Kolch, Walter

“…The ablation of the protein kinase Raf-1 renders cells hypersensitive to apoptosis despite normal regulation of extracellular signal-regulated kinases, which…”
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BGRMI: A method for inferring gene regulatory networks from time-course gene expression data and its application in breast cancer research by Iglesias-Martinez, Luis F., Kolch, Walter, Santra, Tapesh

“…Reconstructing gene regulatory networks (GRNs) from gene expression data is a challenging problem. Existing GRN reconstruction algorithms can be broadly…”
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Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development by Shilo, Asaf, Ben Hur, Vered, Denichenko, Polina, Stein, Ilan, Pikarsky, Eli, Rauch, Jens, Kolch, Walter, Zender, Lars, Karni, Rotem

“…In recent years, it has become clear that splicing factors play a direct role in cancer development. We showed previously that splicing factors SRSF1, SRSF6,…”
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Analysis of Alternative mRNA Splicing in Vemurafenib-Resistant Melanoma Cells by Bokharaie, Honey, Kolch, Walter, Krstic, Aleksandar

“…Alternative mRNA splicing is common in cancers. In BRAF V600E-mutated malignant melanoma, a frequent mechanism of acquired resistance to BRAF inhibitors…”
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ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation by Monypenny, James, Milewicz, Hanna, Flores-Borja, Fabian, Weitsman, Gregory, Cheung, Anthony, Chowdhury, Ruhe, Burgoyne, Thomas, Arulappu, Appitha, Lawler, Katherine, Barber, Paul R., Vicencio, Jose M., Keppler, Melanie, Wulaningsih, Wahyu, Davidson, Sean M., Fraternali, Franca, Woodman, Natalie, Turmaine, Mark, Gillett, Cheryl, Franz, Dafne, Quezada, Sergio A., Futter, Clare E., Von Kriegsheim, Alex, Kolch, Walter, Vojnovic, Borivoj, Carlton, Jeremy G., Ng, Tony

“…The immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA…”
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The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier by Sturm, Oliver E, Orton, Richard, Grindlay, Joan, Birtwistle, Marc, Vyshemirsky, Vladislav, Gilbert, David, Calder, Muffy, Pitt, Andrew, Kholodenko, Boris, Kolch, Walter

“…Three-tiered kinase modules, such as the Raf-MEK (mitogen-activated or extracellular signal-regulated protein kinase kinase)-ERK (extracellular…”
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