Search Results - "KOLBECK, R"

Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor by Molfino, N. A., Gossage, D., Kolbeck, R., Parker, J. M., Geba, G. P.

“…Summary Interleukin‐5 is a Th2 homodimeric cytokine involved in the differentiation, maturation, migration, development, survival, trafficking and effector…”
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Acute activation of bronchopulmonary vagal nociceptors by type I interferons by Patil, Mayur J., Ru, Fei, Sun, Hui, Wang, Jingya, Kolbeck, Roland R., Dong, Xinzhong, Kollarik, Marian, Canning, Brendan J., Undem, Bradley J.

“…Key points Type I interferon receptors are expressed by the majority of vagal C‐fibre neurons innervating the respiratory tract Interferon alpha and beta…”
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IgG1+ B‐cell immunity predates IgE responses in epicutaneous sensitization to foods by Jiménez‐Saiz, R., Ellenbogen, Y., Koenig, J. F. E., Gordon, M. E., Walker, T. D., Rosace, D., Spill, P., Bruton, K., Kong, J., Monteiro, K., Wen, J., Tuomanen, E. I., Kolbeck, R., Chu, D. K., Waserman, S., Jordana, M.

“…Background The generation of IgE‐mediated food allergy in humans is silent and only diagnosed upon manifestation of clinical symptoms. While experimental…”
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Natural killer cell expression of Ki67 is associated with elevated serum IL‐15, disease activity and nephritis in systemic lupus erythematosus by Hudspeth, K., Wang, S., Wang, J., Rahman, S., Smith, M. A., Casey, K. A., Parker, M., White, N., Zerrouki, K., Riggs, J., Ward, B., Bhat, G., Rajan, B., Naiman, B., Grady, R., Groves, C., Manna, Z., Sanjuan, M., Kolbeck, R., Hasni, S., Ettinger, R., Siegel, R. M.

“…Summary Systemic lupus erythematosus (SLE) is a complex autoimmune disorder whose pathology involves multiple immune cell types, including B and T lymphocytes…”
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Anti-IFNAR treatment does not reverse neuropsychiatric disease in MRL/lpr lupus mice by Huang, M W, Stock, A D, Mike, E V, Herlitz, L, Kolbeck, R, Putterman, C

“…Objective Many systemic lupus erythematosus patients display a type I interferon (IFN) signature, and IFNα levels positively correlate with disease severity…”
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Dosimetry of a cone-beam computed tomography machine compared with a digital x-ray machine in orthodontic imaging by Grünheid, Thorsten, Kolbeck Schieck, Jacquelyn R, Pliska, Benjamin T, Ahmad, Mansur, Larson, Brent E

“…Introduction Cone-beam computed tomography (CBCT) has become a routine imaging modality for many orthodontic clinics. However, questions remain about the…”
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T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes by Chu, D K, Mohammed-Ali, Z, Jiménez-Saiz, R, Walker, T D, Goncharova, S, Llop-Guevara, A, Kong, J, Gordon, M E, Barra, N G, Gillgrass, A E, Van Seggelen, H, Khan, W I, Ashkar, A A, Bramson, J L, Humbles, A A, Kolbeck, R, Waserman, S, Jordana, M

“…Intestinal T helper type 2 (Th2) immunity in food allergy results in IgG1 and IgE production, and antigen re-exposure elicits responses such as anaphylaxis and…”
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Expression of CCR8 is increased in asthma by Mutalithas, K., Guillen, C., Raport, C., Kolbeck, R., Soler, D., Brightling, C. E., Pavord, I. D., Wardlaw, A. J.

“…Summary Background Chemokines and their receptors could play key roles in the recruitment of T cells to the asthmatic lung. CCR8 is preferentially expressed on…”
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CD19-positive antibody-secreting cells provide immune memory by Groves, C.J., Carrell, J., Grady, R., Rajan, B., Morehouse, C.A., Halpin, R., Wang, J., Wu, J., Shrestha, Y., Rayanki, R., Kolbeck, R., Wang, Y., Herbst, R.

“…Long-lived antibody-secreting cells (ASCs) are critical for the maintenance of humoral immunity through the continued production of antibodies specific for…”
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Molecular requirements for inhibition of the chemokine receptor CCR8 – probe‐dependent allosteric interactions by Rummel, PC, Arfelt, KN, Baumann, L, Jenkins, TJ, Thiele, S, Lüttichau, HR, Johnsen, A, Pease, J, Ghosh, S, Kolbeck, R, Rosenkilde, MM

“…BACKGROUND AND PURPOSE Here we present a novel series of CCR8 antagonists based on a naphthalene‐sulfonamide structure. This structure differs from the…”
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A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke by BOTELHO, F. M, NIKOTA, J. K, SLEEMAN, M. A, BAUER, C, DAVIS, N. H. E, COHEN, E. S, ANDERSON, I. K, COYLE, A. J, KOLBECK, R, HUMBLES, A. A, STÄMPFLI, M. R

“…We investigated the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in a subchronic exposure model of cigarette smoke (CS)-induced…”
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Reversed binding of a small molecule ligand in homologous chemokine receptors – differential role of extracellular loop 2 by Jensen, PC, Thiele, S, Steen, A, Elder, A, Kolbeck, R, Ghosh, S, Frimurer, TM, Rosenkilde, MM

“…BACKGROUND AND PURPOSE The majority of small molecule compounds targeting chemokine receptors share a similar pharmacophore with a centrally located aliphatic…”
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Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section by Sendtner, M, Holtmann, B, Kolbeck, R, Thoenen, H, Barde, Y.-A

“…Motoneurons innervating the skeletal musculature were among the first neurons shown to require the presence of their target cells to develop appropriately. But…”
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Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood by Al-Garawi, A, Fattouh, R, Botelho, F, Walker, T D, Goncharova, S, Moore, C-L, Mori, M, Erjefalt, J S, Chu, D K, Humbles, A A, Kolbeck, R, Stampfli, M R, O'Byrne, P M, Coyle, A J, Jordana, M

“…The origins of allergic asthma, particularly in infancy, remain obscure. Respiratory viral infections and allergen sensitization in early life have been…”
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Identification of a potent anti‐IL‐15 antibody with opposing mechanisms of action in vitro and in vivo by Finch, DK, Midha, A, Buchanan, CL, Cochrane, D, Craggs, RI, Cruwys, S, Grahames, C, Kolbeck, R, Lowe, DC, Maltby, J, Pattison, DV, Vousden, KA, Ward, A, Sleeman, MA, Mallinder, PR

“…BACKGROUND AND PURPOSE Interleukin‐15 (IL‐15) is important in the activation and proliferation of lymphocytic cell populations and is implicated in…”
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The Epithelial-derived Cytokines TSLP, IL-33, and IL-25 Converge on OX40L to Elicit Peanut Allergy and Anaphylaxis in Mice by Chu, D.K, Llop-Guevara, A, Walker, T.D, Flader, K, Moore, C.L, Goncharova, S, Boudreau, J, Khan, W, Comeau, M.R, Budelsky, A.L, Kolbeck, R, Humbles, A.A, Jordana, M

“…In vitro PN stimulation of bone marrow-derived dendritic cells (BMDCs) limited IL-12p40 production and significantly induced expression of OX40L, which was…”
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Increased superoxide production during fatigue in the perfused rat diaphragm by KOLBECK, R. C, SHE, Z.-W, CALLAHAN, L. A, NOSEK, T. M

“…This study test the hypothesis that a temporal relationship exists between the production of superoxide anion (O2-) and the contractile activity of perfused…”
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MEDI-563, a Humanized Anti-IL-5Ra Antibody with Enhanced Effector Function, Induces Reversible Blood Eosinopenia in Mild Asthmatics by Reed, J.L, Kolbeck, R, Molfino, N, Kozhich, A.A, Humbles, A.A, Erjefalt, J.S, Kiener, P.A, Busse, W.W, Katial, R.K, Leon, F, Spitalny, G.L, Koike, M, Coyle, A.J, White, B

“…Results In vitro MEDI-563 mediated the lysis of IL-5Rα transfected cells with a 200 fold higher potency in comparison to the parental mAb and it potently…”
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Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons by Leingärtner, A, Heisenberg, C P, Kolbeck, R, Thoenen, H, Lindholm, D

“…Neurotrophin-3 (NT-3) is a member of the neurotrophin gene family and is highly expressed in the developing rat cerebellum. Here we show that brain-derived…”
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262 Intratracheal administration of AAV2.5T-SP183-fCFTRΔR in combination with doxorubicin is able to correct the mucociliary clearance defect in cystic fibrosis model ferrets by Excoffon, K., Mahankali, M., Falese, L., Fakhari, S., Yan, Z., Engelhardt, J., Kolbeck, R., Smith, M.

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