Search Results - "KOLB, E"

Development of Chemotherapy with Cell-Cycle Inhibitors for Adult and Pediatric Cancer Therapy by Mills, Christopher C, Kolb, E A, Sampson, Valerie B

“…Preclinical and clinical development of agents that inhibit cell-cycle progression have brought an understanding of the feasibility of targeting various…”
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Gemtuzumab Ozogamicin Improves Event-Free Survival and Reduces Relapse in Pediatric KMT2A -Rearranged AML: Results From the Phase III Children's Oncology Group Trial AAML0531 by Pollard, Jessica A., Guest, Erin, Alonzo, Todd A., Gerbing, Robert B., Loken, Mike R., Brodersen, Lisa Eidenschink, Kolb, E. Anders, Aplenc, Richard, Meshinchi, Soheil, Raimondi, Susana C., Hirsch, Betsy, Gamis, Alan S.

“…PURPOSE We investigated the impact of the CD33-targeted agent gemtuzumab ozogamicin (GO) on survival in pediatric patients with KMT2A-rearranged ( KMT2A-r)…”
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Noise exposure accelerates the risk of cognitive impairment and Alzheimer’s disease: Adulthood, gestational, and prenatal mechanistic evidence from animal studies by Jafari, Zahra, Kolb, Bryan E., Mohajerani, Majid H.

“…•Chronic noise exposure dysregulates the neuroendocrine system leading to hyperactivity of the hypothalamic-pituitary-adrenal (HPA)-axis.•Stress hormones…”
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Chronic traffic noise stress accelerates brain impairment and cognitive decline in mice by Jafari, Zahra, Kolb, Bryan E., Mohajerani, Majid H.

“…Although traffic noise exposure is a well-known environmental pollutant whose negative health effect has been discussed in different aspects of the human life,…”
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Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia by McNeer, Nicole A., Philip, John, Geiger, Heather, Ries, Rhonda E., Lavallée, Vincent-Philippe, Walsh, Michael, Shah, Minita, Arora, Kanika, Emde, Anne-Katrin, Robine, Nicolas, Alonzo, Todd A., Kolb, E. Anders, Gamis, Alan S., Smith, Malcolm, Gerhard, Daniela Se, Guidry-Auvil, Jaime, Meshinchi, Soheil, Kentsis, Alex

“…Acute myeloid leukemias (AML) are characterized by mutations of tumor suppressor and oncogenes, involving distinct genes in adults and children. While certain…”
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Recent Advances of Cell-Cycle Inhibitor Therapies for Pediatric Cancer by Mills, Christopher C, Kolb, E A, Sampson, Valerie B

“…This review describes the pivotal roles of cell-cycle and checkpoint regulators and discusses development of specific cell-cycle inhibitors for therapeutic use…”
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The B7-H3-Targeting Antibody-Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models by Kendsersky, Nathan M, Lindsay, Jarrett, Kolb, E Anders, Smith, Malcolm A, Teicher, Beverly A, Erickson, Stephen W, Earley, Eric J, Mosse, Yael P, Martinez, Daniel, Pogoriler, Jennifer, Krytska, Kateryna, Patel, Khushbu, Groff, David, Tsang, Matthew, Ghilu, Samson, Wang, Yifei, Seaman, Steven, Feng, Yang, Croix, Brad St, Gorlick, Richard, Kurmasheva, Raushan, Houghton, Peter J, Maris, John M

“…Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune…”
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Evaluation of the pan‐class I phosphoinositide 3‐kinase (PI3K) inhibitor copanlisib in the Pediatric Preclinical Testing Consortium in vivo models of osteosarcoma by Harrison, Douglas, Gill, Jonathan, Roth, Michael, Hingorani, Pooja, Zhang, Wendong, Teicher, Beverly, Earley, Eric, Erickson, Stephen, Gatto, Gregory, Kumasheva, Raushan, Houghton, Peter, Smith, Malcolm, Anders Kolb, E., Gorlick, Richard

“…Copanlisib is a pan‐class I phosphoinositide 3‐kinase (PI3K) inhibitor, with activity against all four PI3K class I isoforms (PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ)…”
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Insulin-like growth factor 1 receptor and response to anti-IGF1R antibody therapy in osteosarcoma by Cao, Yu, Roth, Michael, Piperdi, Sajida, Montoya, Kristofer, Sowers, Rebecca, Rao, Pulivarthi, Geller, David, Houghton, Peter, Kolb, E Anders, Gill, Jonathan, Gorlick, Richard

“…Survival outcomes for patients with osteosarcoma (OS) have remained stagnant over the past three decades. Insulin-like growth factor 1 receptor (IGF1R) is…”
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Persistent sulfate formation from London Fog to Chinese haze by Wang, Gehui, Zhang, Renyi, Gomez, Mario E., Yang, Lingxiao, Zamora, Misti Levy, Hu, Min, Lin, Yun, Peng, Jianfei, Guo, Song, Meng, Jingjing, Li, Jianjun, Cheng, Chunlei, Hu, Tafeng, Ren, Yanqin, Wang, Yuesi, Gao, Jian, Cao, Junji, An, Zhisheng, Zhou, Weijian, Li, Guohui, Wang, Jiayuan, Tian, Pengfei, Marrero-Ortiz, Wilmarie, Secrest, Jeremiah, Du, Zhuofei, Zheng, Jing, Shang, Dongjie, Zeng, Limin, Shao, Min, Wang, Weigang, Huang, Yao, Wang, Yuan, Zhu, Yujiao, Li, Yixin, Hu, Jiaxi, Pan, Bowen, Cai, Li, Cheng, Yuting, Ji, Yuemeng, Zhang, Fang, Rosenfeld, Daniel, Liss, Peter S., Duce, Robert A., Kolb, Charles E., Molina, Mario J.

“…Sulfate aerosols exert profound impacts on human and ecosystem health, weather, and climate, but their formation mechanism remains uncertain. Atmospheric…”
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Effect of Charcoal Quantity on Microbial Biomass and Activity in Temperate Soils by Kolb, Simone E, Fermanich, Kevin J, Dornbush, Mathew E

“…Wildfire-produced charcoal is a common component of soils, affecting a range of important abiotic and biotic soil processes. Our ability to predict the effects…”
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Down syndrome and leukemia: An insight into the disease biology and current treatment options by Barwe, Sonali P., Kolb, E. Anders, Gopalakrishnapillai, Anilkumar

“…Children with Down syndrome (DS) have a 10- to 20-fold greater predisposition to develop acute leukemia compared to the general population, with a skew towards…”
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Associations between women's autonomy and child nutritional status: a review of the literature by Carlson, Gwen J., Kordas, Katarzyna, Murray-Kolb, Laura E.

“…Around the world, many women continue to experience low levels of autonomy. Recent literature has reported that the health consequences of low maternal…”
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Measurements of methane emissions at natural gas production sites in the United States by Allen, David T., Torres, Vincent M., Thomas, James, Sullivan, David W., Harrison, Matthew, Al Hendler, Herndon, Scott C., Kolb, Charles E., Fraser, Matthew P., Hill, A. Daniel, Lamb, Brian K., Miskimins, Jennifer, Sawyer, Robert F., Seinfeld, John H.

“…Engineering estimates of methane emissions from natural gas production have led to varied projections of national emissions. This work reports direct…”
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Prenatal noise stress impairs HPA axis and cognitive performance in mice by Jafari, Zahra, Mehla, Jogender, Kolb, Bryan E., Mohajerani, Majid H.

“…Noise stress is a common environmental pollutant whose adverse effect on offspring performance has been less studied. This study was novel in terms of using…”
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Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study by Smith, Jenny L, Ries, Rhonda E, Hylkema, Tiffany, Alonzo, Todd A, Gerbing, Robert B, Santaguida, Marianne T, Eidenschink Brodersen, Lisa, Pardo, Laura, Cummings, Carrie L, Loeb, Keith R, Le, Quy, Imren, Suzan, Leonti, Amanda R, Gamis, Alan S, Aplenc, Richard, Kolb, E Anders, Farrar, Jason E, Triche, Jr, Timothy J, Nguyen, Cu, Meerzaman, Daoud, Loken, Michael R, Oehler, Vivian G, Bolouri, Hamid, Meshinchi, Soheil

“…A cryptic inv(16)(p13.3q24.3) encoding the fusion is associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our…”
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Sorafenib in Combination With Standard Chemotherapy for Children With High Allelic Ratio FLT3 /ITD+ Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML1031 by Pollard, Jessica A, Alonzo, Todd A, Gerbing, Robert, Brown, Patrick, Fox, Elizabeth, Choi, John, Fisher, Brian, Hirsch, Betsy, Kahwash, Samir, Getz, Kelly, Levine, John, Brodersen, Lisa Eidenschink, Loken, Michael R, Raimondi, Susana, Tarlock, Katherine, Wood, Andrew, Sung, Lillian, Kolb, E Anders, Gamis, Alan, Meshinchi, Soheil, Aplenc, Richard

“…High allelic ratio (HAR) /ITD (AR > 0.4) mutations confer poor prognosis in pediatric acute myeloid leukemia (AML). COG AAML1031 studied the feasibility and…”
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Effect of oxidant concentration, exposure time, and seed particles on secondary organic aerosol chemical composition and yield by Lambe, A. T, Chhabra, P. S, Onasch, T. B, Brune, W. H, Hunter, J. F, Kroll, J. H, Cummings, M. J, Brogan, J. F, Parmar, Y, Worsnop, D. R, Kolb, C. E, Davidovits, P

“…We performed a systematic intercomparison study of the chemistry and yields of secondary organic aerosol (SOA) generated from OH oxidation of a common set of…”
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Functional compensation precedes recovery of tissue mass following acute liver injury by Walesky, Chad M., Kolb, Kellie E., Winston, Carolyn L., Henderson, Jake, Kruft, Benjamin, Fleming, Ira, Ko, Sungjin, Monga, Satdarshan P., Mueller, Florian, Apte, Udayan, Shalek, Alex K., Goessling, Wolfram

“…The liver plays a central role in metabolism, protein synthesis and detoxification. It possesses unique regenerative capacity upon injury. While many factors…”
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How is water-use efficiency of terrestrial ecosystems distributed and changing on Earth? by Tang, Xuguang, Li, Hengpeng, Desai, Ankur R., Nagy, Zoltan, Luo, Juhua, Kolb, Thomas E., Olioso, Albert, Xu, Xibao, Yao, Li, Kutsch, Werner, Pilegaard, Kim, Köstner, Barbara, Ammann, Christof

“…A better understanding of ecosystem water-use efficiency (WUE) will help us improve ecosystem management for mitigation as well as adaption to global…”
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