Search Results - "KOLACHANA, B. S"

Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression by Pezawas, L, Meyer-Lindenberg, A, Goldman, A L, Verchinski, B A, Chen, G, Kolachana, B S, Egan, M F, Mattay, V S, Hariri, A R, Weinberger, D R

“…Complex genetic disorders such as depression likely exhibit epistasis, but neural mechanisms of such gene–gene interactions are incompletely understood…”
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Allelic variation in GAD1 (GAD ) is associated with schizophrenia and influences cortical function and gene expression by STRAUB, R. E, LIPSKA, B. K, EGAN, M. F, GOLDBERG, T. E, CALLICOTT, J. H, MAYHEW, M. B, VAKKALANKA, R. K, KOLACHANA, B. S, KLEINMAN, J. E, WEINBERGER, D. R

“…Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the…”
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Schizophrenia is Associated with Elevated Amphetamine-Induced Synaptic Dopamine Concentrations: Evidence from a Novel Positron Emission Tomography Method by Breier, A., T.-P. Su, Saunders, R., Carson, R. E., Kolachana, B. S., De Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., Pickar, D.

“…A major line of evidence that supports the hypothesis of dopamine overactivity in schizophrenia is the psychomimetic potential of agents such as amphetamine…”
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Catechol-o-Methyltransferase Enzyme Activity and Protein Expression in Human Prefrontal Cortex across the Postnatal Lifespan by Tunbridge, EM, Weickert, CS, Kleinman, JE, Herman, MM, Chen, J, Kolachana, BS, Harrison, PJ, Weinberger, DR

“…The prefrontal cortex (PFC) dopamine system, which is critical for modulating PFC function, undergoes remodeling until at least young adulthood in primates…”
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The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function by Egan, Michael F., Kojima, Masami, Callicott, Joseph H., Goldberg, Terry E., Kolachana, Bhaskar S., Bertolino, Alessandro, Zaitsev, Eugene, Gold, Bert, Goldman, David, Dean, Michael, Lu, Bai, Weinberger, Daniel R.

“…Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and hippocampal-dependent memory in cell models and in animals. We examined the…”
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Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine by Saunders, Richard C, Kolachana, Bhaskar S, Bachevalier, Jocelyne, Weinberger, Daniel R

“…The effects of early brain damage are often, but not always, milder than the effects of comparable damage in adults, depending on the age at which injury…”
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Kinetic modeling of [11C]raclopride: combined PET-microdialysis studies by Endres, C J, Kolachana, B S, Saunders, R C, Su, T, Weinberger, D, Breier, A, Eckelman, W C, Carson, R E

“…The in vivo binding of D2 receptor ligands can be affected by agents that alter the concentration of endogenous dopamine. To define a more explicit relation…”
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Attenuated extracellular dopamine levels after stress and amphetamine in the nucleus accumbens of rats with neonatal ventral hippocampal damage by LILLRANK, S. M, LIPSKA, B. K, KOLACHANA, B. S, WEINBERGER, D. R

“…In vivo microdialysis was used to study the effects of restraint stress (30 min) and amphetamine (AMPH) (5 mg/kg, i.p.) in awake adult male rats with neonatal…”
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Augmentation of prefrontal cortical monoaminergic activity inhibits dopamine release in the caudate nucleus: An in vivo neurochemical assessment in the rhesus monkey by Kolachana, B.S., Saunders, R.C., Weinberger, D.R.

“…Prefrontal cortical modulation of caudate nucleus dopamine release was investigated in the rhesus monkey using the in vivo microdialysis technique. Reliable…”
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Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase ( COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain by Chen, Jingshan, Lipska, Barbara K., Halim, Nader, Ma, Quang D., Matsumoto, Mitsuyuki, Melhem, Samer, Kolachana, Bhaskar S., Hyde, Thomas M., Herman, Mary M., Apud, Jose, Egan, Michael F., Kleinman, Joel E., Weinberger, Daniel R.

“…Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the prefrontal cortex of the human brain. Genetic variation in the COMT…”
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Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms by Sei, Y, Ren-Patterson, R, Li, Z, Tunbridge, E M, Egan, M F, Kolachana, B S, Weinberger, D R

“…Neuregulin1 (NRG1), a candidate susceptibility gene for schizophrenia, plays a critical role in neuronal migration and central nervous system development…”
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Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain by Akil, Mayada, Kolachana, Bhaskar S, Rothmond, Debora A, Hyde, Thomas M, Weinberger, Daniel R, Kleinman, Joel E

“…A functional polymorphism in the gene for catechol-O-methyltransferase (COMT) has been shown to affect executive cognition and the physiology of the prefrontal…”
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The BDNF Val66Met polymorphism has a gender specific influence on planning ability in parkinson's disease by FOLTYNIE, Thomas, LEWIS, Simon G. J, GOLDBERG, Terry E, BLACKWELL, Andrew D, KOLACHANA, Bhaskar S, WEINBERGER, Daniel R, ROBBINS, Trevor W, BARKER, Roger A

“…Parkinson's disease (PD) patients show a range of cognitive deficits,which may relate to abnormalities in dopaminergic transmission in fronto-striatal…”
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Effects of ibotenic acid lesion of the medial prefrontal cortex on dopamine agonist-related behaviors in the rat by Braun, A R, Jaskiw, G E, Vladar, K, Sexton, R H, Kolachana, B S, Weinberger, D R

“…Behavioral responses to apomorphine and to the selective D1 and D2 dopamine receptor agonists SK&F38393 and quinpirole were evaluated in rats following…”
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MET BDNF protects against morphological S allele effects of 5-HTTLPR by Pezawas, L, Meyer-Lindenberg, A, Goldman, A L, Verchinski, B A, Chen, G, Kolachana, B S, Egan, M F, Mattay, V S, Hariri, A R, Weinberger, D R

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Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey : an in vivo microdialysis study by SAUNDERS, R. C, KOLACHANA, B. S, WEINBERGER, D. R

“…The prefrontal cortex, caudate nucleus, and their dopaminergic innervations have been implicated in complex information processing. The present study utilized…”
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Evidence for a frontocortical-septal glutamatergic pathway and compensatory changes in septal glutamate uptake after cortical and fornix lesions in the rat by Jaskiw, G E, Tizabi, Y, Lipska, B K, Kolachana, B S, Wyatt, R J, Gilad, G M

“…To determine the source of glutamatergic input to the septum and to the nucleus accumbens septi, glutamate uptake was assessed after transections of the…”
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An improved methodology for routine in vivo microdialysis in non-human primates by Kolachana, B S, Saunders, R C, Weinberger, D R

“…A new method was developed to carry out in vivo microdialysis experiments repetitively and routinely within an individual monkey. We designed and built a…”
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Microdialysis in nonhuman primates by Saunders, R C, Kolachana, B S, Weinberger, D R

“…This unit presents a technique that allows for routine repeated microdialysis experiments in the monkey using a sedated preparation or, with further minor…”
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Prefrontal Electrophysiologic “Noise” and Catechol- O-Methyltransferase Genotype in Schizophrenia by Winterer, Georg, Egan, Michael F., Kolachana, Bhaskar S., Goldberg, Terry E., Coppola, Richard, Weinberger, Daniel R.

“…Increased variability of stimulus-induced prefrontal electromagnetic activity (“noise”) has been associated with genetic risk for schizophrenia. On the basis…”
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