Search Results - "KOLACHANA, B"

Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans by Meyer-Lindenberg, A, Kolachana, B, Gold, B, Olsh, A, Nicodemus, K K, Mattay, V, Dean, M, Weinberger, D R

“…In mammals, the neuropeptide vasopressin is a key molecule for complex emotional and social behaviours. Two microsatellite polymorphisms, RS1 and RS3, near the…”
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Impact of complex genetic variation in COMT on human brain function by MEYER-LINDENBERG, A, NICHOLS, T, CALLICOTT, J. H, DING, J, KOLACHANA, B, BUCKHOLTZ, J, MATTAY, V. S, EGAN, M, WEINBERGER, D. R

“…Catechol-O-methyltransferase (COMT) has been shown to be critical for prefrontal dopamine flux, prefrontal cortex-dependent cognition and activation. Several…”
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Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression by Pezawas, L, Meyer-Lindenberg, A, Goldman, A L, Verchinski, B A, Chen, G, Kolachana, B S, Egan, M F, Mattay, V S, Hariri, A R, Weinberger, D R

“…Complex genetic disorders such as depression likely exhibit epistasis, but neural mechanisms of such gene–gene interactions are incompletely understood…”
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Allelic variation in GAD1 (GAD ) is associated with schizophrenia and influences cortical function and gene expression by STRAUB, R. E, LIPSKA, B. K, EGAN, M. F, GOLDBERG, T. E, CALLICOTT, J. H, MAYHEW, M. B, VAKKALANKA, R. K, KOLACHANA, B. S, KLEINMAN, J. E, WEINBERGER, D. R

“…Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the…”
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The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function by Egan, Michael F., Kojima, Masami, Callicott, Joseph H., Goldberg, Terry E., Kolachana, Bhaskar S., Bertolino, Alessandro, Zaitsev, Eugene, Gold, Bert, Goldman, David, Dean, Michael, Lu, Bai, Weinberger, Daniel R.

“…Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and hippocampal-dependent memory in cell models and in animals. We examined the…”
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Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression by Kunii, Y, Hyde, T M, Ye, T, Li, C, Kolachana, B, Dickinson, D, Weinberger, D R, Kleinman, J E, Lipska, B K

“…Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32 or PPP1R1B ) has been of interest in schizophrenia owing to its critical…”
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COMT genotype predicts cortical-limbic D1 receptor availability measured with [ C]NNC112 and PET by Slifstein, M, Kolachana, B, Simpson, E H, Tabares, P, Cheng, B, Duvall, M, Gordon Frankle, W, Weinberger, D R, Laruelle, M, Abi-Dargham, A

“…A common polymorphism (val158met) in the gene encoding catechol- O -methyltransferase (COMT) has been shown to affect dopamine (DA) tone in cortex and cortical…”
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Catechol-o-Methyltransferase Enzyme Activity and Protein Expression in Human Prefrontal Cortex across the Postnatal Lifespan by Tunbridge, EM, Weickert, CS, Kleinman, JE, Herman, MM, Chen, J, Kolachana, BS, Harrison, PJ, Weinberger, DR

“…The prefrontal cortex (PFC) dopamine system, which is critical for modulating PFC function, undergoes remodeling until at least young adulthood in primates…”
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Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality by Buckholtz, J W, Callicott, J H, Kolachana, B, Hariri, A R, Goldberg, T E, Genderson, M, Egan, M F, Mattay, V S, Weinberger, D R, Meyer-Lindenberg, A

“…Little is known about neural mechanisms underlying human personality and temperament, despite their considerable importance as highly heritable risk mediators…”
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Schizophrenia is Associated with Elevated Amphetamine-Induced Synaptic Dopamine Concentrations: Evidence from a Novel Positron Emission Tomography Method by Breier, A., T.-P. Su, Saunders, R., Carson, R. E., Kolachana, B. S., De Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., Pickar, D.

“…A major line of evidence that supports the hypothesis of dopamine overactivity in schizophrenia is the psychomimetic potential of agents such as amphetamine…”
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Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia by Eisenberg, D P, Ianni, A M, Wei, S-M, Kohn, P D, Kolachana, B, Apud, J, Weinberger, D R, Berman, K F

“…A Val(66)Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured…”
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Epistatic interactions of AKT1 on human medial temporal lobe biology and pharmacogenetic implications by Tan, H Y, Chen, A G, Chen, Q, Browne, L B, Verchinski, B, Kolachana, B, Zhang, F, Apud, J, Callicott, J H, Mattay, V S, Weinberger, D R

“…AKT1 controls important processes in medial temporal lobe (MTL) development and plasticity, but the impact of human genetic variation in AKT1 on these…”
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Variation in the Williams syndrome GTF2I gene and anxiety proneness interactively affect prefrontal cortical response to aversive stimuli by Jabbi, M, Chen, Q, Turner, N, Kohn, P, White, M, Kippenhan, J S, Dickinson, D, Kolachana, B, Mattay, V, Weinberger, D R, Berman, K F

“…Characterizing the molecular mechanisms underlying the heritability of complex behavioral traits such as human anxiety remains a challenging endeavor for…”
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Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms by Sei, Y, Ren-Patterson, R, Li, Z, Tunbridge, E M, Egan, M F, Kolachana, B S, Weinberger, D R

“…Neuregulin1 (NRG1), a candidate susceptibility gene for schizophrenia, plays a critical role in neuronal migration and central nervous system development…”
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Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase ( COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain by Chen, Jingshan, Lipska, Barbara K., Halim, Nader, Ma, Quang D., Matsumoto, Mitsuyuki, Melhem, Samer, Kolachana, Bhaskar S., Hyde, Thomas M., Herman, Mary M., Apud, Jose, Egan, Michael F., Kleinman, Joel E., Weinberger, Daniel R.

“…Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the prefrontal cortex of the human brain. Genetic variation in the COMT…”
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Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine by Saunders, Richard C, Kolachana, Bhaskar S, Bachevalier, Jocelyne, Weinberger, Daniel R

“…The effects of early brain damage are often, but not always, milder than the effects of comparable damage in adults, depending on the age at which injury…”
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Hippocampal dysfunction in schizophrenia: association with brain-derived neurotrophic factor genotype by Eisenberg, D P, Ianni, A M, Wei, S-M, Kohn, P D, Kolachana, B, Apud, J, Weinberger, D R, Berman, K F

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Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain by Akil, Mayada, Kolachana, Bhaskar S, Rothmond, Debora A, Hyde, Thomas M, Weinberger, Daniel R, Kleinman, Joel E

“…A functional polymorphism in the gene for catechol-O-methyltransferase (COMT) has been shown to affect executive cognition and the physiology of the prefrontal…”
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Kinetic modeling of [11C]raclopride: combined PET-microdialysis studies by Endres, C J, Kolachana, B S, Saunders, R C, Su, T, Weinberger, D, Breier, A, Eckelman, W C, Carson, R E

“…The in vivo binding of D2 receptor ligands can be affected by agents that alter the concentration of endogenous dopamine. To define a more explicit relation…”
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Attenuated extracellular dopamine levels after stress and amphetamine in the nucleus accumbens of rats with neonatal ventral hippocampal damage by LILLRANK, S. M, LIPSKA, B. K, KOLACHANA, B. S, WEINBERGER, D. R

“…In vivo microdialysis was used to study the effects of restraint stress (30 min) and amphetamine (AMPH) (5 mg/kg, i.p.) in awake adult male rats with neonatal…”
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