Search Results - "KOLA, I"

The State of Innovation in Drug Development by Kola, I

“…The pharmaceutical industry is facing tremendous pressure, not only from payers but as a result of public perception, regulatory hurdles, and the intricacies…”
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Anterior interosseous nerve syndrome (Kiloh Nevin Syndrome) revealing Gantzer muscle and simultaneous myasthenia gravis by Musa, J., Rahman, M., Kola, I., Guy, A., Pena, L., Lekoubou, A., Hyseni, F., Compres, L., Saliaj, K., Blanco, R.

“…There hasn't been a previous case report of the anterior interosseous nerve injury secondary to the presence of the muscle of Gantzer in a patient with…”
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SUN-PP071: Absence of Enteral Feeding is a Risk Factor for Infections and Mortality in ICU Patients with Severe Acute Pancreatitis by Shpata, V, Kurti, F, Hoxha, A, Kola, I, Prendushi, X, Duni, A

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Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization by Gowen, Maxine, Lazner, Francesca, Dodds, Robert, Kapadia, Rasesh, Feild, John, Tavaria, Michael, Bertoncello, Ivan, Drake, Fred, Zavarselk, Silva, Tellis, Irene, Hertzog, Paul, Debouck, Christine, Kola, Ismail

“…Cathepsin K is a cysteine protease expressed predominantly in osteoclasts. Activated cathepsin K cleaves key bone matrix proteins and is believed to play an…”
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PP031-SUN: Elderly Critically Ill Patients have a Higher Risk for Malnutrition and Poor Clinical Outcome than Younger Patients by Shpata, V, Ktona, E, Prendushi, X, Duni, A, Kola, I, Nurçe, A

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PP027-SUN ENERGY DEFICIT INCREASES THE RISK OF POOR CLINICAL OUTCOME IN CRITICALLY ILL PATIENTS by Shpata, V, Nurka, T, Kito, I, Çela, A, Kola, I, Hoxha, A

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PP010-MON PRE-OPERATIVE MALNUTRITION IS ASSOCIATED WITH POOR OUTCOME IN SURGICAL CRITICALLY ILL PATIENTS by Shpata, V, Nurçe, A, Çela, A, Kreka, M, Kola, I, Prendushi, X

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Physiotherapy efficiency in postmenopausal women with osteoporosis by Kola, I, Shpata, V, Kola, S, Nurce, A

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Vertebral column deformities in obese children in Albania by Kola, I, Kola, S, Shpata, V, Nurce, A

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ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway by Wolvetang, E.J., Wilson, T.J., Sanij, E., Busciglio, J., Hatzistavrou, T., Seth, A., Hertzog, P.J., Kola, I.

“…ETS2 is a transcription factor encoded by a gene on human chromosome 21 and alterations in its expression have been implicated in the pathophysiological…”
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Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis by Wolvetang, E.J, Bradfield, O.M, Hatzistavrou, T, Crack, P.J, Busciglio, J, Kola, I, Hertzog, P.J

“…Down syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this increased cell death remain to…”
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A Null Mutation in the Gene Encoding a Type I Interferon Receptor Component Eliminates Antiproliferative and Antiviral Responses to Interferons α and β and Alters Macrophage responses by Hwang, Seung Y., Hertzog, Paul J., Holland, Kerry A., Sumarsono, Sony H., Tymms, Martin J., Hamilton, John A., Whitty, Genevieve, Bertoncello, Ivan, Kola, Ismail

“…To examine the in vivo role(s) of type I interferons (IFNs) and to determine the role of a component of the type I IFN receptor (IFNAR1) in mediating responses…”
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The LoxP/CRE system and genome modification by Wilson, T J, Kola, I

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The Ets1 Transcription Factor is Widely Expressed During Murine Embryo Development and is Associated with Mesodermal Cells Involved in Morphogenetic Processes such as Organ Formation by Kola, Ismail, Brookes, Sarah, Green, Anthony R., Garber, Richard, Tymms, Martin, Papas, Takis S., Seth, Arun

“…The Ets family of genes encodes a class of transcription factors. Ets1 is predominantly expressed in the lymphoid organs of neonatal and adult mice, whereas…”
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Detailed mapping of the ERG– ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16 by Owczarek, C.M., Portbury, K.J., Hardy, M.P., O'Leary, D.A., Kudoh, J., Shibuya, K., Shimizu, N., Kola, I., Hertzog, P.J.

“…We have carried out a detailed annotation of 550 kb of genomic DNA on human chromosome 21 containing the ERG and ETS2 genes. Comparative genomic analysis…”
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Animal Models in the Study of the Biological Function of Genes on Human Chromosome 21 and Their Role in the Pathophysiology of Down Syndrome by Kola, Ismail, Hertzog, Paul J.

“…Human chromosome 21 is the smallest human autosome and many important genetic/familial disorders map to this chromosome, e.g., familial amyotrophic lateral…”
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Can the pharmaceutical industry reduce attrition rates? by Kola, Ismail, Landis, John

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Centrioles in the Beginning of Human Development by Sathananthan, A. H., Kola, I., Osborne, J., Trounson, A., Ng, S. C., Bongso, A., Ratnam, S. S.

“…We demonstrate the presence of centrioles in fertilized human oocytes at syngamy. Single or double centrioles within centrosomes were detected by transmission…”
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Decreased natural killer cell activity in endometriosis patients: relationship to disease pathogenesis by Wilson, T J, Hertzog, P J, Angus, D, Munnery, L, Wood, E C, Kola, I

“…A number of reports have measured NK cell activity in patients with endometriosis with varied results. Therefore we have examined the NK activity of PBL from…”
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The "gene dosage effect" hypothesis versus the "amplified developmental instability" hypothesis in Down syndrome by Pritchard, M A, Kola, I

“…Two hypotheses exist to explain the Down syndrome (DS) phenotype. The "gene dosage effect" hypothesis states that the phenotype is a direct result of the…”
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