Search Results - "KOKUBU, N"

Establishment and characterization of adriamycin-resistant human colorectal adenocarcinoma HCT-15 cell lines with multidrug resistance by Uchiyama-Kokubu, Noriko, Watanabe, Toru

“…The multidrug resistance (MDR) phenotype, either intrinsic and/or acquired, is discussed in relation to several MDR-associated markers such as P-glycoprotein…”
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Regression of established tumors expressing P-glycoprotein by combinations of adriamycin, cyclosporin derivatives, and MRK-16 antibodies by WATANABE, T, NAITO, M, KOKUBU, N, TSURUO, T

“…Overexpression of P-glycoprotein, a transmembrane protein capable of transporting a broad spectrum of anticancer drugs out of cells, likely contributes to…”
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Is GLP-1 insufficiency a coronary risk factor? A multicenter observational study, BOREAS-CAD2 by Nagase, C, Tanno, M, Kouzu, H, Miki, T, Nishida, J, Murakami, N, Kokubu, N, Nagano, N, Nishikawa, R, Yoshioka, N, Tsuchida, A, Kita, H, Ohnishi, H, Miura, T

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P904Early commencement of tolvaptan therapy improves clinical outcomes in heart failure patients with preserved function of renal vasopressin V2 receptors by Noto, T, Tanno, M, Nagano, N, Osanami, A, Kouzu, H, Kokubu, N, Yano, T, Miki, T, Miura, T

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P2736Prognostic impact of coagulopathy at hospital admission on 30-day neurological outcomes in patients with out-of-hospital cardiac arrest by Murakami, N., Kokubu, N., Kamada, Y., Noto, T., Nagano, N., Nishida, J., Tsuchihashi, K., Narimatsu, E., Miura, T.

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A bioassay for the activity of PSC 833 in human serum for modulation of P-glycoprotein-mediated multidrug resistance by Uchiyama-Kokubu, Noriko, Watanabe, Toru, Nakajima, Motowo

“…We established a rapid and sensitive ex vivo bioassay to detect the multidrug resistance (MDR)-inhibitory activity of SDZ PSC 833…”
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Para-Hisian pacing enabled separate assessments of bundle branch conduction and ventricular myocardium conduction, disclosing distinct determinants by Shimoshige, S., Mochizuki, A., Nishida, J., Kouzu, H., Kokubu, N., Muranaka, A., Yuda, S., Hashimoto, A., Tsuchihashi, K., Miura, T.

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Prognostic evaluation of patients with pulmonary hypertension by combined non-invasive assessment of pulmonary vascular resistance and right ventricular function by Kawamukai, M., Koyama, M., Nishida, J., Kouzu, H., Muranaka, A., Kokubu, N., Yuda, S., Hashimoto, A., Tsuchihashi, K., Miura, T.

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Enhanced bioavailability of subcutaneously injected insulin by pretreatment with ointment containing protease inhibitors by TAKEYAMA, M, ISHIDA, T, KOKUBU, N, KOMADA, F, IWAKAWA, S, OKUMURA, K, HORI, R

“…The present study was undertaken to develop an ointment preparation containing a protease inhibitor for stabilizing subcutaneously injected insulin. The…”
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Relationship between potency of L-isoprenaline and beta-adrenoceptor density estimated in single cells from tracheal smooth muscles of guinea pigs of different ages by Takayanagi, I, Satoh, M, Kokubu, N, Kato, T

“…An age-related change in potency of L-isoprenaline in the presence of ascorbic acid, desmethylimipramine, corticosterone, pargyline, and phentolamine was…”
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Possible Impairment of Transcardiac Utilization of Adiponectin in Patients With Type 2 Diabetes by Furuhashi, Masato, Ura, Nobuyuki, Moniwa, Norihito, Shinshi, Yasuyuki, Kouzu, Hidemichi, Nishihara, Masahiro, Kokubu, Nobuaki, Takahashi, Toru, Sakamoto, Ken-Ichi, Hayashi, Manabu, Satoh, Naotoshi, Nishitani, Takahiro, Shikano, Yasukuni, Shimamoto, Kazuaki

“…Possible Impairment of Transcardiac Utilization of Adiponectin in Patients With Type 2 Diabetes Masato Furuhashi , MD 1 2 , Nobuyuki Ura , MD 1 , Norihito…”
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Transport of somatostatin and substance P by human P-glycoprotein by Uchiyama-Kokubu, Noriko, Naito, Mikihiko, Nakajima, Motowo, Tsuruo, Takashi

“…P-glycoprotein is an efflux pump for a broad spectrum of hydrophobic agents. We found that bioactive peptides including somatostatin and substance P inhibit…”
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Tantalum and Niobium in Ascidians by KOKUBU, N, HIDAKA, T

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Early Defibrillation and Circulatory Support Can Provide Better Long-Term Outcomes Through Favorable Neurological Recovery in Patients With Out-of-Hospital Cardiac Arrest of Cardiac Origin by Hase, Mamoru, Tsuchihashi, Kazufumi, Fujii, Noriyuki, Nishizato, Kimio, Kokubu, Nobuaki, Nara, Satoshi, Kurimoto, Yoshihiko, Hashimoto, Akiyoshi, Uno, Kikuya, Miura, Tetsuji, Ura, Nobuyuki, Asai, Yasufumi, Shimamoto, Kazuaki

“…Background Early defibrillation and cardiopulmonary bypass have been postulated to be a promising intervention against out-of-hospital cardiac arrest (OHCA);…”
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Functional Modulation of ATPase of P-Glycoprotein by C219, a Monoclonal Antibody against P-Glycoprotein by Kokubu, Noriko, Cohen, Dalia, Watanabe, Toru

“…P-glycoprotein functions as an ATP-driven efflux pump for antitumor agents. C219 is a monoclonal antibody which recognizes regions near both ATP binding…”
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High-dose dobutamine stress myocardial fatty acid imaging can identify transient contractile dysfunction underestimated by stress perfusion imaging by Hashimoto, A. Akiyoshi, Kokubu, N., Nishizato, K., Yuda, S., Uno, K., Nakata, T., Tsuchihashi, K., Shimamoto, K., Nagao, K., Takada, T.

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Interaction of cyclosporin derivatives with the ATPase activity of human P‐glycoprotein by Watanabe, Toru, Kokubu, Noriko, Charnick, Steven B., Naito, Mikihiko, Tsuruo, Takashi, Cohen, Dalia

“…1 P‐glycoprotein, a 170–180 kDa membrane glycoprotein that mediates multidrug resistance, hydrolyses ATP to efflux a broad spectrum of hydrophobic agents. In…”
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Phase I Study of Intravenous PSC‐833 and Doxorubicin: Reversal of Multidrug Resistance by Minami, Hironobu, Ohtsu, Tomoko, Fujii, Hirofumi, Igarashi, Tadahiko, Itoh, Kuniaki, Uchiyama‐Kokubu, Noriko, Aizawa, Tetsushi, Watanabe, Torn, Uda, Yoshinori, Tanigawara, Yusuke, Sasaki, Yasutsuna

“…PSC‐833 reverses multidrug resistance by P‐glycoprotein at concentrations <1000 ng/ml. A phase I study of PSC‐833 and doxorubicin was conducted to determine…”
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Involvement of botulinum C3-sensitive GTP-binding proteins in alpha 1-adrenoceptor subtypes mediating Ca(2+)-sensitization by Kokubu, N, Satoh, M, Takayanagi, I

“…The mechanisms of alpha 1-adrenoceptor agonist-mediated sensitization of the contractile apparatus of smooth muscle to Ca2+ were studied in…”
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Intracellular Levels of Two Cyclosporin Derivatives Valspodar (PSC 833) and Cyclosporin A Closely Associated with Multidrug Resistance‐modulating Activity in Sublines of Human Colorectal Adenocarcinoma HCT‐15 by Uchiyama‐Kokubu, Noriko, Watanabe, Toru, Cohen, Dalia

“…P‐Glycoprotein, which mediates multidrug resistance (MDR) in cancer chemotherapy, is a principal target of Cyclosporin A and [3′‐keto‐Bmt1]‐[Val2]‐cyclosporin…”
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