Search Results - "KOKOZA, Vladimir"

MicroRNA-277 targets insulin-like peptides 7 and 8 to control lipid metabolism and reproduction in Aedes aegypti mosquitoes by Ling, Lin, Kokoza, Vladimir A., Zhang, Changyu, Aksoy, Emre, Raikhel, Alexander S.

“…Hematophagous femalemosquitoes transmit numerous devastating human diseases, including malaria, dengue fever, Zika virus, and others. Because of their…”
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microRNA-309 targets the Homeobox gene SIX4 and controls ovarian development in the mosquito Aedes aegypti by Zhang, Yang, Zhao, Bo, Roy, Sourav, Saha, Tusar T., Kokoza, Vladimir A., Li, Ming, Raikhel, Alexander S.

“…Obligatory blood-triggered reproductive strategy is an evolutionary adaptation of mosquitoes for rapid egg development. It contributes to the vectorial…”
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MicroRNA-275 targets sarco/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA) to control key functions in the mosquito gut by Zhao, Bo, Lucas, Keira J, Saha, Tusar T, Ha, Jisu, Ling, Lin, Kokoza, Vladimir A, Roy, Sourav, Raikhel, Alexander S

“…The yellow fever mosquito Aedes aegypti is the major vector of arboviruses, causing numerous devastating human diseases, such as dengue and yellow fevers,…”
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MicroRNA-8 targets the Wingless signaling pathway in the female mosquito fat body to regulate reproductive processes by Lucas, Keira J., Roy, Sourav, Ha, Jisu, Gervaise, Amanda L., Kokoza, Vladimir A., Raikhel, Alexander S.

“…Female mosquitoes require a blood meal for reproduction, and this blood meal provides the underlying mechanism for the spread of many important vector-borne…”
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Targeted gene expression in the transgenic Aedes aegypti using the binary Gal4-UAS system by Kokoza, Vladimir A, Raikhel, Alexander S

“…In this study, we report the establishment of the binary Gal4/UAS system for the yellow fever mosquito Aedes aegypti. We utilized the 1.8-kb 5′ upstream region…”
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Transcriptome analysis of Aedes aegypti transgenic mosquitoes with altered immunity by Zou, Zhen, Souza-Neto, Jayme, Xi, Zhiyong, Kokoza, Vladimir, Shin, Sang Woon, Dimopoulos, George, Raikhel, Alexander

“…The mosquito immune system is involved in pathogen-elicited defense responses. The NF-κB factors REL1 and REL2 are downstream transcription activators of Toll…”
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Blocking of Plasmodium transmission by cooperative action of Cecropin A and Defensin A in transgenic Aedes aegypti mosquitoes by Kokoza, Vladimir, Ahmed, Abdouelaziz, Woon Shin, Sang, Okafor, Nwando, Zou, Zhen, Raikhel, Alexander S

“…To overcome burden of mosquito-borne diseases, multiple control strategies are needed. Population replacement with genetically modified mosquitoes carrying…”
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Determination of juvenile hormone titers by means of LC-MS/MS/MS and a juvenile hormone-responsive Gal4/UAS system in Aedes aegypti mosquitoes by Zhao, Bo, Hou, Yuan, Wang, Jianjun, Kokoza, Vladimir A., Saha, Tusar T., Wang, Xue-Li, Lin, Ling, Zou, Zhen, Raikhel, Alexander S.

“…In anautogenous mosquitoes, juvenile hormone III (JH) plays an essential role in female post-eclosion (PE) development, preparing them for subsequent blood…”
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Distinct Melanization Pathways in the Mosquito Aedes aegypti by Zou, Zhen, Shin, Sang Woon, Alvarez, Kanwal S., Kokoza, Vladimir, Raikhel, Alexander S.

“…Serine protease cascades are involved in blood coagulation and immunity. In arthropods, they regulate melanization, which plays an important role in immune…”
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Regulation of the gut-specific carboxypeptidase: A study using the binary Gal4/UAS system in the mosquito Aedes aegypti by Zhao, Bo, Kokoza, Vladimir A., Saha, Tusar T., Wang, Stephanie, Roy, Sourav, Raikhel, Alexander S.

“…Pathogen transmission by mosquitoes is tightly linked to blood feeding which, in turn, is required for egg development. Studies of these processes would…”
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Mosquito RUNX4 in the immune regulation of PPO gene expression and its effect on avian malaria parasite infection by Zou, Zhen, Shin, Sang Woon, Alvarez, Kanwal S, Bian, Guowu, Kokoza, Vladimir, Raikhel, Alexander S

“…Prophenoloxidases (PPOs) are key enzymes of the melanization reaction, which is a prominent defense mechanism of arthropods. The mosquito Aedes aegypti has ten…”
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REL1, a Homologue of Drosophila Dorsal, Regulates Toll Antifungal Immune Pathway in the Female Mosquito Aedes aegypti by Shin, Sang Woon, Kokoza, Vladimir, Bian, Guowu, Cheon, Hyang-Mi, Kim, Yu Jung, Raikhel, Alexander S.

“…Signaling by Drosophila Toll pathway activates two Rel/NF-κB transcription factors, Dorsal (Dl) and Dorsal-related immune factor (Dif). Dl plays a central role…”
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Transgenic alteration of Toll immune pathway in the female mosquito Aedes aegypti by Bian, G, Shin, S.W, Cheon, H.M, Kokoza, V, Raikhel, A.S

“…Reverse genetics is a powerful tool for understanding gene functions and their interactions in the mosquito innate immunity. We took the transgenic approach,…”
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Molecular biology of mosquito vitellogenesis: from basic studies to genetic engineering of antipathogen immunity by Raikhel, Alexander S., Kokoza, Vladimir A., Zhu, Jinsong, Martin, David, Wang, Sheng-Fu, Li, Chao, Sun, Guoqiang, Ahmed, Abdoulaziz, Dittmer, Neal, Attardo, Geoff

“…Elucidation of molecular mechanisms underlying stage- and tissue-specific expression of genes activated by a blood meal is of great importance for current…”
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Transcriptional regulation of the mosquito vitellogenin gene via a blood meal-triggered cascade by Kokoza, Vladimir A, Martin, David, Mienaltowski, Michael J, Ahmed, Abdouelaziz, Morton, Christina M, Raikhel, Alexander S

“…In anautogenous mosquitoes, a blood meal is required for activation of genes encoding yolk protein precursors (YPP). Vitellogenin (Vg), the major YPP gene, is…”
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Engineering Blood Meal-Activated Systemic Immunity in the Yellow Fever Mosquito, Aedes aegypti by Kokoza, Vladimir, Ahmed, Abduelaziz, Cho, Wen-Long, Jasinskiene, Nijole, James, Anthony A., Raikhel, Alexander

“…Progress in molecular genetics makes possible the development of alternative disease control strategies that target the competence of mosquitoes to transmit…”
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Relish-mediated immune deficiency in the transgenic mosquito Aedes aegypti by Shin, S.W, Kokoza, V, Lobkov, L, Raikhel, A.S

“…The lack of genetic means has been a serious limitation in studying mosquito immunity. We generated Relish-mediated immune deficiency (RMID) by transforming…”
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Internalization of LDL-receptor superfamily yolk-protein receptors during mosquito oogenesis involves transcriptional regulation of PTB-domain adaptors by Mishra, Sanjay K, Jha, Anupma, Steinhauser, Amie L, Kokoza, Vladimir A, Washabaugh, Charles H, Raikhel, Alexander S, Foster, Woodbridge A, Traub, Linton M

“…In the anautogenous disease vector mosquitoes Anopheles gambiae and Aedes aegypti, egg development is nutritionally controlled. A blood meal permits further…”
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Transgenesis and reverse genetics of mosquito innate immunity by Shin, Sang Woon, Kokoza, Vladimir A, Raikhel, Alexander S

“…In recent years, mosquito molecular biology has been a scene of astounding achievements, namely the development of genetic transformation, characterization of…”
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Molecular characterization of the mosquito vitellogenin receptor reveals unexpected high homology to the Drosophila yolk protein receptor by Sappington, T.W. (Michigan State University, East Lansing, MI.), Kokoza, V.A, Cho, W.L, Raikhel, A.S

“…The mosquito (Aedes aegypti) vitellogenin receptor (AaVgR) is a large membrane-bound protein (214 kDa when linearized) that mediates internalization of…”
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