Search Results - "KOKOTOS, GEORGE"

Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer by Barbayianni, Efrosini, Kaffe, Eleanna, Aidinis, Vassilis, Kokotos, George

“…Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family of ectoenzymes that hydrolyzes phosphodiester bonds of various…”
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Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention by Dennis, Edward A, Cao, Jian, Hsu, Yuan-Hao, Magrioti, Victoria, Kokotos, George

“…Dennis et al examine phospholipase A2 enzymes with regard to, among other things, chemical inhibition, and therapeutic intervention…”
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Nitro Fatty Acids (NO 2 -FAs): An Emerging Class of Bioactive Fatty Acids by Koutoulogenis, Giorgos S, Kokotos, George

“…Unsaturated nitro fatty acids (NO -FAs) constitute a category of molecules that may be formed endogenously by the reaction of unsaturated fatty acids (UFAs)…”
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Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2 by Nikolaou, Aikaterini, Kokotou, Maroula G., Vasilakaki, Sofia, Kokotos, George

“…Phospholipase A2 (PLA2) enzymes are involved in various inflammatory pathological conditions including arthritis, cardiovascular and autoimmune diseases. The…”
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Development of a Liquid Chromatography-High Resolution Mass Spectrometry Method for the Determination of Free Fatty Acids in Milk by Kokotou, Maroula G, Mantzourani, Christiana, Kokotos, George

“…The determination of free fatty acids (FFAs) in milk is of importance for quality control, legislative purposes, authentication and product development. We…”
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A Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) Method for the Determination of Free Hydroxy Fatty Acids in Cow and Goat Milk by Kokotou, Maroula G, Mantzourani, Christiana, Bourboula, Asimina, Mountanea, Olga G, Kokotos, George

“…A liquid chromatography-high resolution mass spectrometry (LC-HRMS) method for the direct determination of various saturated hydroxy fatty acids (HFAs) in milk…”
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Small Peptides Able to Suppress Prostaglandin E₂ Generation in Renal Mesangial Cells by Vasilakaki, Sofia, Pastukhov, Oleksandr, Mavromoustakos, Thomas, Huwiler, Andrea, Kokotos, George

“…Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to…”
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Autotaxin inhibitors: a patent review (2012-2016) by Nikolaou, Aikaterini, Kokotou, Maroula G, Limnios, Dimitris, Psarra, Anastasia, Kokotos, George

“…Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to lysophosphatidic acid (LPA) and choline. The ATX/LPA axis has received…”
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Primary Amine‐Thioureas based on tert‐Butyl Esters of Natural Amino Acids as Organocatalysts for the Michael Reaction by Kokotos, Christoforos G., Kokotos, George

“…A new class of primary amine‐thioureas based on tert‐butyl esters of (S)‐α‐amino acids and (1S,2S)‐diphenylethylenediamine was synthesized and their activity…”
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Enantioselective Organocatalysis-Based Synthesis of 3-Hydroxy Fatty Acids and Fatty γ-Lactones by Bourboula, Asimina, Limnios, Dimitris, Kokotou, Maroula G, Mountanea, Olga G, Kokotos, George

“…3-Hydroxy fatty acids have attracted the interest of researchers, since some of them may interact with free fatty acid receptors more effectively than their…”
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Identification of a Dual Inhibitor of Secreted Phospholipase A2 (GIIA sPLA2) and SARS-CoV-2 Main Protease by Theodoropoulou, Maria A., Koutoulogenis, Giorgos S., Zhang, Linlin, Akrani, Ifigeneia, Mikros, Emmanuel, Hilgenfeld, Rolf, Kokotos, George

“…The development of novel agents to combat COVID-19 is of high importance. SARS-CoV-2 main protease (Mpro) is a highly attractive target for the development of…”
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Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrophages by Gil-de-Gómez, Luis, Astudillo, Alma M, Guijas, Carlos, Magrioti, Victoria, Kokotos, George, Balboa, María A, Balsinde, Jesús

“…Phospholipase A2s generate lipid mediators that constitute an important component of the integrated response of macrophages to stimuli of the innate immune…”
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Study of the Royal Jelly Free Fatty Acids by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) by Kokotou, Maroula G, Mantzourani, Christiana, Babaiti, Rodalia, Kokotos, George

“…The lipidome of royal jelly (RJ) consists of medium-chained (8-12 carbon atoms) free fatty acids. We present herein a liquid chromatography-high resolution…”
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Asymmetric Synthesis of Saturated and Unsaturated Hydroxy Fatty Acids (HFAs) and Study of Their Antiproliferative Activity by Mountanea, Olga G, Mantzourani, Christiana, Gkikas, Dimitrios, Politis, Panagiotis K, Kokotos, George

“…Hydroxy fatty acids (HFAs) constitute a class of lipids, distinguished by the presence of a hydroxyl on a long aliphatic chain. This study aims to expand our…”
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2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2 by Kokotou, Maroula G., Galiatsatou, Gerasimia, Magrioti, Victoria, Koutoulogenis, Giorgos, Barbayianni, Efrosini, Limnios, Dimitris, Mouchlis, Varnavas D., Satpathy, Banita, Navratil, Aaron, Dennis, Edward A., Kokotos, George

“…Cytosolic phospholipase A 2 (GIVA cPLA 2 ) is the only PLA 2 that exhibits a marked preference for hydrolysis of arachidonic acid containing phospholipid…”
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The Contribution of Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A2s to Adrenic Acid Mobilization in Murine Macrophages by Monge, Patricia, Garrido, Alvaro, Rubio, Julio M., Magrioti, Victoria, Kokotos, George, Balboa, María A., Balsinde, Jesús

“…Adrenic acid (AA), the 2-carbon elongation product of arachidonic acid, is present at significant levels in membrane phospholipids of mouse peritoneal…”
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Free Saturated Oxo Fatty Acids (SOFAs) and Ricinoleic Acid in Milk Determined by a Liquid Chromatography-High-Resolution Mass Spectrometry (LC-HRMS) Method by Kokotou, Maroula G, Batsika, Charikleia S, Mantzourani, Christiana, Kokotos, George

“…Oxidized saturated fatty acids, containing a hydroxyl or an oxo functionality, have attracted little attention so far. Recent studies have shown that saturated…”
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Sulfonamides of homoproline and dipeptides as organocatalysts for Michael and aldol reactions by Tsandi, Evaggelia, Kokotos, Christoforos G., Kousidou, Sofia, Ragoussis, Valentine, Kokotos, George

“…Sulfonamides of the non-natural amino acid homoproline and the dipeptide Pro–Phe were synthesised and evaluated for their catalytic activity in Michael and…”
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Cellular Plasmalogen Content Does Not Influence Arachidonic Acid Levels or Distribution in Macrophages: A Role for Cytosolic Phospholipase A2γ in Phospholipid Remodeling by Lebrero, Patricia, Astudillo, Alma M., Rubio, Julio M., Fernández-Caballero, Lidia, Kokotos, George, Balboa, María A., Balsinde, Jesús

“…Availability of free arachidonic acid (AA) constitutes a rate limiting factor for cellular eicosanoid synthesis. AA distributes differentially across membrane…”
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Synthesis of Amino-Acid-Based Nitroalkenes by Gerogianni, Velisaria-Eleni, Koutoulogenis, Giorgos S., Gerokonstantis, Dimitrios Triantafyllos, Kokotos, George

“…Fatty-acid-based nitroalkenes have recently received great attention because of their bioactivities. On the contrary, peptide- or amino-acid-based nitroalkenes…”
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