Search Results - "KOISTINAHO, Jari"

Metabolic alterations in Parkinson’s disease astrocytes by Sonninen, Tuuli-Maria, Hämäläinen, Riikka H., Koskuvi, Marja, Oksanen, Minna, Shakirzyanova, Anastasia, Wojciechowski, Sara, Puttonen, Katja, Naumenko, Nikolay, Goldsteins, Gundars, Laham-Karam, Nihay, Lehtonen, Marko, Tavi, Pasi, Koistinaho, Jari, Lehtonen, Šárka

“…In Parkinson`s disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta is associated with Lewy bodies arising from the…”
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Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review by Kettunen, Pinja, Koistinaho, Jari, Rolova, Taisia

“…Central nervous system infections have been suggested as a possible cause for neurodegenerative diseases, particularly sporadic cases. They trigger…”
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Dysfunction of Cellular Proteostasis in Parkinson's Disease by Lehtonen, Šárka, Sonninen, Tuuli-Maria, Wojciechowski, Sara, Goldsteins, Gundars, Koistinaho, Jari

“…Despite decades of research, current therapeutic interventions for Parkinson's disease (PD) are insufficient as they fail to modify disease progression by…”
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Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke by Kolosowska, Natalia, Keuters, Meike H., Wojciechowski, Sara, Keksa-Goldsteine, Velta, Laine, Mika, Malm, Tarja, Goldsteins, Gundars, Koistinaho, Jari, Dhungana, Hiramani

“…Neuroinflammation is strongly induced by cerebral ischemia. The early phase after the onset of ischemic stroke is characterized by acute neuronal injury,…”
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Blood-Brain Barrier and Neurodegenerative Diseases-Modeling with iPSC-Derived Brain Cells by Wu, Ying-Chieh, Sonninen, Tuuli-Maria, Peltonen, Sanni, Koistinaho, Jari, Lehtonen, Šárka

“…The blood-brain barrier (BBB) regulates the delivery of oxygen and important nutrients to the brain through active and passive transport and prevents…”
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Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling by Koivumäki, Jussi T, Naumenko, Nikolay, Tuomainen, Tomi, Takalo, Jouni, Oksanen, Minna, Puttonen, Katja A, Lehtonen, Šárka, Kuusisto, Johanna, Laakso, Markku, Koistinaho, Jari, Tavi, Pasi

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising experimental tool for translational heart research and drug…”
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An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo by Keuters, Meike Hedwig, Keksa-Goldsteine, Velta, Dhungana, Hiramani, Huuskonen, Mikko T., Pomeshchik, Yuriy, Savchenko, Ekaterina, Korhonen, Paula K., Singh, Yajuvinder, Wojciechowski, Sara, Lehtonen, Šárka, Kanninen, Katja M., Malm, Tarja, Sirviö, Jouni, Muona, Anu, Koistinaho, Milla, Goldsteins, Gundars, Koistinaho, Jari

“…Lipid peroxidation-initiated ferroptosis is an iron-dependent mechanism of programmed cell death taking place in neurological diseases. Here we show that a…”
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Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice by Puris, Elena, Kouřil, Štěpán, Najdekr, Lukáš, Loppi, Sanna, Korhonen, Paula, Kanninen, Katja M., Malm, Tarja, Koistinaho, Jari, Friedecký, David, Gynther, Mikko

“…Peripheral infections followed by systemic inflammation may contribute to the onset of Alzheimer`s disease (AD) and accelerate the disease progression later in…”
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Microglial amyloid beta clearance is driven by PIEZO1 channels by Jäntti, Henna, Sitnikova, Valeriia, Ishchenko, Yevheniia, Shakirzyanova, Anastasia, Giudice, Luca, Ugidos, Irene F, Gómez-Budia, Mireia, Korvenlaita, Nea, Ohtonen, Sohvi, Belaya, Irina, Fazaludeen, Feroze, Mikhailov, Nikita, Gotkiewicz, Maria, Ketola, Kirsi, Lehtonen, Šárka, Koistinaho, Jari, Kanninen, Katja M, Hernández, Damian, Pébay, Alice, Giugno, Rosalba, Korhonen, Paula, Giniatullin, Rashid, Malm, Tarja

“…Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In…”
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Neuron-astrocyte transmitophagy is altered in Alzheimer's disease by Lampinen, Riikka, Belaya, Irina, Saveleva, Liudmila, Liddell, Jeffrey R., Rait, Dzhessi, Huuskonen, Mikko T., Giniatullina, Raisa, Sorvari, Annika, Soppela, Liisi, Mikhailov, Nikita, Boccuni, Isabella, Giniatullin, Rashid, Cruz-Haces, Marcela, Konovalova, Julia, Koskuvi, Marja, Domanskyi, Andrii, Hämäläinen, Riikka H., Goldsteins, Gundars, Koistinaho, Jari, Malm, Tarja, Chew, Sweelin, Rilla, Kirsi, White, Anthony R., Marsh-Armstrong, Nicholas, Kanninen, Katja M.

“…Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely…”
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Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction by Sabogal-Guáqueta, Angélica María, Marmolejo-Garza, Alejandro, Trombetta-Lima, Marina, Oun, Asmaa, Hunneman, Jasmijn, Chen, Tingting, Koistinaho, Jari, Lehtonen, Sarka, Kortholt, Arjan, Wolters, Justina C., Bakker, Barbara M., Eggen, Bart J. L., Boddeke, Erik, Dolga, Amalia

“…Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from oxidative…”
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Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease by Kanninen, Katja, Heikkinen, Riikka, Malm, Tarja, Rolova, Taisia, Kuhmonen, Susanna, Leinonen, Hanna, Ylä-Herttuala, Seppo, Tanila, Heikki, Levonen, Anna-Liisa, Koistinaho, Milla, Koistinaho, Jari

“…The amyloid hypothesis of Alzheimer's disease (AD) postulates that amyloid-β (Aβ) deposition and neurotoxicity play a causative role in AD; oxidative injury is…”
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PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease by Oksanen, Minna, Petersen, Andrew J., Naumenko, Nikolay, Puttonen, Katja, Lehtonen, Šárka, Gubert Olivé, Max, Shakirzyanova, Anastasia, Leskelä, Stina, Sarajärvi, Timo, Viitanen, Matti, Rinne, Juha O., Hiltunen, Mikko, Haapasalo, Annakaisa, Giniatullin, Rashid, Tavi, Pasi, Zhang, Su-Chun, Kanninen, Katja M., Hämäläinen, Riikka H., Koistinaho, Jari

“…Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient understanding of the disease…”
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Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells by Peltonen, Sanni, Sonninen, Tuuli-Maria, Niskanen, Jonna, Koistinaho, Jari, Ruponen, Marika, Lehtonen, Šárka

“…Background Pericytes play a crucial role in controlling inflammation and vascular functions in the central nervous system, which are disrupted in Parkinson's…”
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Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation by Korhonen, Paula, Kanninen, Katja M, Lehtonen, Šárka, Lemarchant, Sighild, Puttonen, Katja A, Oksanen, Minna, Dhungana, Hiramani, Loppi, Sanna, Pollari, Eveliina, Wojciechowski, Sara, Kidin, Iurii, García-Berrocoso, Teresa, Giralt, Dolors, Montaner, Joan, Koistinaho, Jari, Malm, Tarja

“…Highlights • Human stroke patients show reduced levels of interleukin-33 inhibitory receptor sST2. • Interleukin-33 administration is protective in a mouse…”
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The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis by Pollari, Eveliina, Goldsteins, Gundars, Bart, Geneviève, Koistinaho, Jari, Giniatullin, Rashid

“…Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motoneurons and degradation of the neuromuscular junctions (NMJ). Consistent…”
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ADAMTS proteoglycanases in the physiological and pathological central nervous system by Lemarchant, Sighild, Pruvost, Mathilde, Montaner, Joan, Emery, Evelyne, Vivien, Denis, Kanninen, Katja, Koistinaho, Jari

“…ADAMTS-1, -4, -5 and -9 belong to 'a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)' family and more precisely to the proteoglycanases…”
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Benserazide is neuroprotective and improves functional recovery after experimental ischemic stroke by altering the immune response by Keuters, Meike Hedwig, Keksa-Goldsteine, Velta, Rõlova, Taisia, Jaronen, Merja, Kettunen, Pinja, Halkoluoto, Aurora, Goldsteins, Gundars, Koistinaho, Jari, Dhungana, Hiramani

“…Stroke is a leading cause of permanent disability worldwide. Despite intensive research over the last decades, key anti-inflammatory strategies that have…”
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The role and therapeutic potential of monocytic cells in Alzheimer's disease by Malm, Tarja, Koistinaho, Milla, Muona, Anu, Magga, Johanna, Koistinaho, Jari

“…Alzheimer's disease (AD) is a dementing neurodegenerative disorder without a cure. The abnormal parenchymal accumulation of β‐amyloid (Aβ) is associated with…”
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Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy by Leinonen, Henri, Keksa-Goldsteine, Velta, Ragauskas, Symantas, Kohlmann, Philip, Singh, Yajuvinder, Savchenko, Ekaterina, Puranen, Jooseppi, Malm, Tarja, Kalesnykas, Giedrius, Koistinaho, Jari, Tanila, Heikki, Kanninen, Katja M.

“…The Finnish variant of late infantile neuronal ceroid lipofuscinosis (CLN5 disease) belongs to a family of neuronal ceroid lipofuscinosis (NCLs) diseases…”
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