Search Results - "KOISHI, RYUTA"

Angiopoietin-Like Protein3 Regulates Plasma HDL Cholesterol Through Suppression of Endothelial Lipase by Shimamura, Mitsuru, Matsuda, Morihiro, Yasumo, Hiroaki, Okazaki, Mitsuyo, Fujimoto, Kazunori, Kono, Keita, Shimizugawa, Tetsuya, Ando, Yosuke, Koishi, Ryuta, Kohama, Takafumi, Sakai, Naohiko, Kotani, Kazuaki, Komuro, Ryutaro, Ishida, Tatsuo, Hirata, Kenichi, Yamashita, Shizuya, Furukawa, Hidehiko, Shimomura, Iichiro

“…OBJECTIVES—A low level of high-density lipoprotein (HDL) in plasma has been recognized as an aspect of metabolic syndrome and as a crucial risk factor of…”
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Discovery of a Novel Class of State-Dependent NaV1.7 Inhibitors for the Treatment of Neuropathic Pain by Tanaka, Kyosuke, Kobayashi, Hiroyuki, Suzuki, Sayaka, Shibuya, Satoshi, Kimoto, Hiroko, Domon, Yuki, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Shinozuka, Tsuyoshi

“…The discovery of a novel class of state-dependent voltage-gated sodium channel (NaV)1.7 inhibitors is described. By the modification of amide or urethane bond…”
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Mice lacking fat storage-inducing transmembrane protein 2 show improved profiles upon pressure overload-induced heart failure by Nishihama, Natsumi, Nagayama, Takahiro, Makino, Shinji, Koishi, Ryuta

“…Fat storage-inducing transmembrane proteins 1 and 2 (FITM1 and FITM2, respectively) are transmembrane endoplasmic/sarcoplasmic reticulum proteins involved in…”
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ANGPTL3 Decreases Very Low Density Lipoprotein Triglyceride Clearance by Inhibition of Lipoprotein Lipase by Shimizugawa, Tetsuya, Ono, Mitsuru, Shimamura, Mitsuru, Yoshida, Kenichi, Ando, Yosuke, Koishi, Ryuta, Ueda, Kenjiro, Inaba, Toshimori, Minekura, Hiroyuki, Kohama, Takafumi, Furukawa, Hidehiko

“…KK/San is a mutant mouse strain established in our laboratory from KK obese mice. KK/San mice show low plasma lipid levels compared with wild-type KK mice…”
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Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors by Suzuki, Sayaka, Kuroda, Takeshi, Kimoto, Hiroko, Domon, Yuki, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Shimizugawa, Akiko, Sugita, Ryusuke, Koishi, Ryuta, Asano, Daigo, Tamaki, Kazuhiko, Shinozuka, Tsuyoshi, Kobayashi, Hiroyuki

“…[Display omitted] A novel class of NaV1.7 inhibitors has been identified by high-throughput screening followed by structure activity relationship studies…”
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A Superfamily of Voltage-gated Sodium Channels in Bacteria by Koishi, Ryuta, Xu, Haoxing, Ren, Dejian, Navarro, Betsy, Spiller, Benjamin W., Shi, Qing, Clapham, David E.

“…NaChBac, a six-α-helical transmembrane-spanning protein cloned from Bacillus halodurans, is the first functionally characterized bacterial voltage-gated…”
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Angptl3-null Mice Show Low Plasma Lipid Concentrations by Enhanced Lipoprotein Lipase Activity by FUJIMOTO, Kazunori, KOISHI, Ryuta, SHIMIZUGAWA, Tetsuya, ANDO, Yosuke

“…Angiopoietin-like 3 (ANGPTL3) is a secreted protein with both angiogenesis and lipid metabolism functions. We generated knockout mice that failed to express…”
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Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor by Shimamura, Mitsuru, Matsuda, Morihiro, Ando, Yosuke, Koishi, Ryuta, Yasumo, Hiroaki, Furukawa, Hidehiko, Shimomura, Iichiro

“…We reported previously that angiopoietin-like protein3 (ANGPTL3), a liver-specific secretory factor, increased plasma triglyceride (TG) via inhibition of…”
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A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice by Ando, Yosuke, Shimizugawa, Tetsuya, Takeshita, Shigehito, Ono, Mitsuru, Shimamura, Mitsuru, Koishi, Ryuta, Furukawa, Hidehiko

“…KK/Snk mice (previously KK/San) possessing a recessive mutation (hypl) of the angiopoietin-like 3 (Angptl3) gene homozygously exhibit a marked reduction of…”
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Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor by FUJITA, YOSHIFUMI, TAKAHASHI, TOMOKO, SUZUKI, AKIKO, KAWASHIMA, KAYO, NARA, FUTOSHI, KOISHI, RYUTA

“…Dresden G protein-coupled receptor (D-GPCR) is one of orphan G protein-coupled receptors (GPCR). Here we report the identification of the ligands and the…”
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Angiopoietin-like Protein 3 Mediates Hypertriglyceridemia Induced by the Liver X Receptor by Inaba, Toshimori, Matsuda, Morihiro, Shimamura, Mitsuru, Takei, Norihide, Terasaka, Naoki, Ando, Yosuke, Yasumo, Hiroaki, Koishi, Ryuta, Makishima, Makoto, Shimomura, Iichiro

“…The KK/San obese and diabetic mouse, a mutant strain from KK obese mice, exhibits significantly low plasma triglyceride levels. In KK/San mice, genetic…”
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Protein Region Important for Regulation of Lipid Metabolism in Angiopoietin-like 3 (ANGPTL3) by Ono, Mitsuru, Shimizugawa, Tetsuya, Shimamura, Mitsuru, Yoshida, Kenichi, Noji-Sakikawa, Chisa, Ando, Yosuke, Koishi, Ryuta, Furukawa, Hidehiko

“…Angiopoietin-like 3 (ANGPTL3) is a secreted protein that is mainly expressed in the liver and regulates lipid metabolism by inhibiting the lipolysis of…”
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Cloning and Characterization of a Novel Oxidoreductase KDRF from a Human Bone Marrow-derived Stromal Cell Line KM-102 by Koishi, Ryuta, Kawashima, Ichiro, Yoshimura, Chigusa, Sugawara, Mie, Serizawa, Nobufusa

“…A cDNA clone coding for a novel oxidoreductase was cloned from a human bone marrow-derived stromal cell line KM-102. We screened a cDNA library constructed…”
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Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor by Shinozuka, Tsuyoshi, Kobayashi, Hiroyuki, Suzuki, Sayaka, Tanaka, Kyosuke, Karanjule, Narayan, Hayashi, Noriyuki, Tsuda, Toshifumi, Tokumaru, Eri, Inoue, Masahiro, Ueda, Kiyono, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Abe, Yasuyuki, Watanabe, Toshiyuki, Kitano, Yutaka

“…A highly potent, selective NaV1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives (I and II) led…”
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N -Aryl Indoles as a Novel Class of Potent Na V 1.7 Inhibitors by Karanjule, Narayan, Hayashi, Noriyuki, Suzuki, Sayaka, Tsuda, Toshifumi, Tokumaru, Eri, Tanaka, Kyosuke, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Koishi, Ryuta, Fujiwara, Chie, Inaba, Shinichi, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Shinozuka, Tsuyoshi

“…A novel class of potent Na 1.7 inhibitors has been discovered. The replacement of diaryl ether in compound was investigated to enhance mouse Na 1.7 inhibitory…”
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N‑Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors by Karanjule, Narayan, Hayashi, Noriyuki, Suzuki, Sayaka, Tsuda, Toshifumi, Tokumaru, Eri, Tanaka, Kyosuke, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Koishi, Ryuta, Fujiwara, Chie, Inaba, Shinichi, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Shinozuka, Tsuyoshi

“…A novel class of potent NaV1.7 inhibitors has been discovered. The replacement of diaryl ether in compound I was investigated to enhance mouse NaV1.7…”
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Discovery of DS-1971a, a Potent, Selective Na V 1.7 Inhibitor by Shinozuka, Tsuyoshi, Kobayashi, Hiroyuki, Suzuki, Sayaka, Tanaka, Kyosuke, Karanjule, Narayan, Hayashi, Noriyuki, Tsuda, Toshifumi, Tokumaru, Eri, Inoue, Masahiro, Ueda, Kiyono, Kimoto, Hiroko, Domon, Yuki, Takahashi, Sakiko, Kubota, Kazufumi, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Sakakura, Tomoko, Takasuna, Kiyoshi, Abe, Yasuyuki, Watanabe, Toshiyuki, Kitano, Yutaka

“…A highly potent, selective Na 1.7 inhibitor, DS-1971a, has been discovered. Exploration of the left-hand phenyl ring of sulfonamide derivatives ( and ) led to…”
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Production of functional human selenocysteine-containing KDRF/thioredoxin reductase in E. coli by Koishi, R, Nakamura, T, Takazawa, T, Yoshimura, C, Serizawa, N

“…In a previous study, we reported the isolation of a cDNA encoding KDRF (KM-102-derived reductase like factor) from the human bone marrow-derived stromal cell…”
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Angptl3 regulates lipid metabolism in mice by Koishi, Ryuta, Ando, Yosuke, Ono, Mitsuru, Shimamura, Mitsuru, Yasumo, Hiroaki, Fujiwara, Toshihiko, Horikoshi, Hiroyoshi, Furukawa, Hidehiko

“…The KK obese mouse is moderately obese and has abnormally high levels of plasma insulin (hyperinsulinemia), glucose (hyperglycemia) and lipids…”
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Molecular cloning and expression of the gene encoding a phospholipase A1 from Aspergillus oryzae by Watanabe, I. (Sankyo Co. Ltd., Tokyo (Japan). Central Research Lab.), Koishi, R, Yao, Y, Tsuji, T, Serizawa, N

“…Phospholipase A1 (PLA1) is a hydrolytic enzyme that catalyzes removal of the acyl group from position 1 of lecithin to form lysolecithin. The genomic DNA and…”
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