EFFECT OF CEPHRADINE IN ACUTE SIMPLE CYSTITIS: COMPARATIVE TEST BY DOUBLE BLIND METHOD

EFFECT OF CEPHRADINE IN ACUTE SIMPLE CYSTITIS COMPARATIVE TEST BY DOUBLE BLIND METHOD

1) Clinical effect of cephradine was examined by means of double blind method with cephalexin as the standard drug in the patients of acute simple cystitis who visited Department of Urology, Kyushu University and other related 12 hospitals. 2) Though cephradine and cephalexin was administered respec...

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Published in:CHEMOTHERAPY Vol. 23; no. 1; pp. 409 - 429
Main Authors: KUMAZAWA, JYOICHI, NAKAMUTA, SEIICHI, MOMOSE, SHUNRO, ARIYOSHI, ASAMI, OSHIMA, KAZUHIRO, FUJISAWA, YASUHITO, HIRATSUKA, YOSHIHARU, HIRATA, KOZO, MORITA, ICHIKIRO, HIEDA, SADAMU, OTA, YASUHIRO, OSADA, YUKIO, TAKESUE, TETSURO, TAKAMATSU, CHUJI, ANDO, SEIICHIRO, HIRANO, HARUKA, NAGAYOSHI, HIROYUKI, KIDA, HIROSHI, KIYOHARA, HIROHIKO, OMARU, KOICHI, HIDAKA, MASAAKI, FUJII, KIMIYA, NAKAYAMA, HIROSHI, KANO, MOTONORI, HIRATA, HIROSHI, AMANO, TAKUYA, HARA, SANSHIN, HARA, TAKAHIKO, NANRI, KAZUSHIGE, YAMAGUCHI, AKITO, OGAWA, NOBUYA, KOIKE, SEIJUN
Format: Journal Article
Language:Japanese
Published: Japanese Society of Chemotherapy 1975
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Summary:1) Clinical effect of cephradine was examined by means of double blind method with cephalexin as the standard drug in the patients of acute simple cystitis who visited Department of Urology, Kyushu University and other related 12 hospitals. 2) Though cephradine and cephalexin was administered respectively in 250 cases, examination was completed only in 218 cases (female 209 cases, male 9 cases), as 32 cases dropped out en route. 3) Cephradine administration group consisted of 108 cases, and cephalexin administration group 110 cases. No significant deviation was noticed between the case composition of two groups. 4) As a synthetic clinical effect, it was excellent in 87 cases, good in 20 cases, poor in 1 case (effective ratio : 99. 1%) out of 108 cases of cephradine administration group, while excilent in 95 cases, good in 15 cases (effective ratio : 100%) out of 110 cases of cephalexin administration group, and no statistically significant difference was observed between two groups. Improvement degrees were compared on each item of pollakisuria, miction pain, DONNE's reaction and others, and no significant difference was recognized between cephradine group and cephalexin group. 5) Bacteria isolated from urine were mostly E. coli, followed by a small number of Staphylococcus, Proteus and others. Clinical results were compared classifying into bacterial species, and no significant difference was observed between cephradine group and cephalexin group. With E. coli, MIC was a grade higher in cephradine than in cephalexin, but no significant difference was noticed clinically between two groups. 6) As a side effect with the drug, it was noticed in 3 cases among cephradine group, and yet the administration interruption was not necessary, as all the effects were moderate gastrointestinal disorders. No significant difference was observed statistically between cephradine group and cephalexin group. 7) From the above results, it was clarified that cephradine is extremely effective for acute simple cystitis, there is no significant difference between clinical and bacteriological effects of cephradine and cephalexin, and thus cephradine may be used similarly to cephalexin.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.23.409