Search Results - "KOHNO, Shohei"

Enhancement of antitumor activity by using 5-ALA-mediated sonodynamic therapy to induce apoptosis in malignant gliomas: significance of high-intensity focused ultrasound on 5-ALA-SDT in a mouse glioma model by Suehiro, Satoshi, Ohnishi, Takanori, Yamashita, Daisuke, Kohno, Shohei, Inoue, Akihiro, Nishikawa, Masahiro, Ohue, Shiro, Tanaka, Junya, Kunieda, Takeharu

“…OBJECTIVEHigh invasiveness of malignant gliomas frequently causes early local recurrence of the tumor, resulting in extremely poor outcome. To control such…”
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Simultaneous inhibition of FXR and TGR5 exacerbates atherosclerotic formation by Miyazaki-Anzai, Shinobu, Masuda, Masashi, Kohno, Shohei, Levi, Moshe, Shiozaki, Yuji, Keenan, Audrey L., Miyazaki, Makoto

“…Simultaneous activation of bile acid receptors farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5) by INT-767 significantly reduces…”
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Inhibition of skeletal muscle differentiation by calciprotein particles in human primary myoblasts by Kohno, Shohei, Uno, Eisuke, Goishi, Kazuto, Kharaghani, Davood, Uchibe, Kenta, Terayama, Ryuji

“…Sarcopenia is a common complication of chronic kidney disease (CKD) and has a detrimental effect on prognosis. Previous studies have explored the role of…”
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The CDK9–cyclin T1 complex mediates saturated fatty acid–induced vascular calcification by inducing expression of the transcription factor CHOP by Shiozaki, Yuji, Okamura, Kayo, Kohno, Shohei, Keenan, Audrey L., Williams, Kristina, Zhao, Xiaoyun, Chick, Wallace S., Miyazaki-Anzai, Shinobu, Miyazaki, Makoto

“…Vascular calcification (or mineralization) is a common complication of chronic kidney disease (CKD) and is closely associated with increased mortality and…”
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The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation by Riley, Christopher L., Dao, Christine, Kenaston, M. Alexander, Muto, Luigina, Kohno, Shohei, Nowinski, Sara M., Solmonson, Ashley D., Pfeiffer, Matthew, Sack, Michael N., Lu, Zhongping, Fiermonte, Giuseppe, Sprague, Jon E., Mills, Edward M.

“…Key points Both uncoupling protein 1 (UCP1) and UCP3 are important for mammalian thermoregulation. UCP1 and UCP3 in brown adipose tissue mediate early and late…”
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miR340 suppresses the stem-like cell function of glioma-initiating cells by targeting tissue plasminogen activator by Yamashita, Daisuke, Kondo, Toru, Ohue, Shiro, Takahashi, Hisaaki, Ishikawa, Madoka, Matoba, Ryo, Suehiro, Satoshi, Kohno, Shohei, Harada, Hironobu, Tanaka, Junya, Ohnishi, Takanori

“…Glioma-initiating cells (GIC) have stem-like cell properties thought to be sufficient for recurrence, progression, and drug resistance in glioblastomas. In the…”
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An N-terminal-truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy by Kohno, Shohei, Shiozaki, Yuji, Keenan, Audrey L, Miyazaki-Anzai, Shinobu, Miyazaki, Makoto

“…Autophagy is a conserved system that adapts to nutrient starvation, after which proteins and organelles are degraded to recycle amino acids in response to…”
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Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma by Nishikawa, Masahiro, Inoue, Akihiro, Ohnishi, Takanori, Yano, Hajime, Ozaki, Saya, Kanemura, Yonehiro, Suehiro, Satoshi, Ohtsuka, Yoshihiro, Kohno, Shohei, Ohue, Shiro, Shigekawa, Seiji, Watanabe, Hideaki, Kitazawa, Riko, Tanaka, Junya, Kunieda, Takeharu

“…•CD44, upregulated by HIF-1α under 1%O2, induces highly invasive phenotype GSCs.•HIF-2α-activated OPN under 5%O2 promotes less-invasive/proliferative type…”
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A case of primary central nervous system anaplastic lymphoma kinase-positive anaplastic large cell lymphoma in the neurohypophysis and pineal gland by Omae, Ryo, Kohno, Shohei, Shinko, Aiko, Asano, Takeru, Takahashi, Kazuya

“…Most primary central nervous system lymphomas (PCNSLs) are diffuse large B-cell lymphomas (DLBCLs). Anaplastic large cell lymphoma (ALCL), which is a T-cell…”
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Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma by Ozaki, Saya, Yano, Hajime, Takahashi, Hisaaki, Kitazawa, Riko, Tanaka, Junya, Kunieda, Takeharu, Yamashita, Daisuke, Suehiro, Satoshi, Matsumoto, Shirabe, Ohue, Shiro, Kohno, Shohei, Ohnishi, Takanori, Inoue, Akihiro, Nishikawa, Masahiro, Watanabe, Hideaki

“…Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the…”
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Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation by Ito, Shota, Minamizaki, Tomoko, Kohno, Shohei, Sotomaru, Yusuke, Kitaura, Yoshiaki, Ohba, Shinsuke, Sugiyama, Toshie, Aubin, Jane E., Tanimoto, Kotaro, Yoshiko, Yuji

“…We recently reported an unexpected role of osteoblast-derived matrix vesicles in the delivery of microRNAs to bone matrix. Of such microRNAs, we found that…”
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Tricks and traps of ICG endoscopy for effectively applying endoscopic transsphenoidal surgery to pituitary adenoma by Inoue, Akihiro, Kohno, Shohei, Ohnishi, Takanori, Nishida, Naoya, Suehiro, Satoshi, Nakamura, Yawara, Matsumoto, Shirabe, Nishikawa, Masahiro, Ozaki, Saya, Shigekawa, Seiji, Watanabe, Hideaki, Senba, Hidenori, Nakaguchi, Hironobu, Taniwaki, Mashio, Matsuura, Bunzo, Kitazawa, Riko, Kunieda, Takeharu

“…Differentiating tumor from normal pituitary gland is very important for achieving complete resection without complications in endoscopic endonasal…”
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Capric Acid Up-Regulates UCP3 Expression without PDK4 Induction in Mouse C2C12 Myotubes by ABE, Tomoki, HIRASAKA, Katsuya, KOHNO, Shohei, TOMIDA, Chisato, HARUNA, Marie, UCHIDA, Takayuki, OHNO, Ayako, OARADA, Motoko, TESHIMA-KONDO, Shigetada, OKUMURA, Yuushi, CHOI, Inho, AOYAMA, Toshiaki, TERAO, Junji, NIKAWA, Takeshi

“…Uncoupling protein 3 (UCP3) and pyruvate dehydrogenase kinase 4 (PDK4) in skeletal muscle are key regulators of the glucose and lipid metabolic processes that…”
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CD44 expression in the tumor periphery predicts the responsiveness to bevacizumab in the treatment of recurrent glioblastoma by Nishikawa, Masahiro, Inoue, Akihiro, Ohnishi, Takanori, Yano, Hajime, Kanemura, Yonehiro, Kohno, Shohei, Ohue, Shiro, Ozaki, Saya, Matsumoto, Shirabe, Suehiro, Satoshi, Nakamura, Yawara, Shigekawa, Seiji, Watanabe, Hideaki, Kitazawa, Riko, Tanaka, Junya, Kunieda, Takeharu

“…Antiangiogenic therapy with bevacizumab (Bev), a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is a common treatment for recurrent…”
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Ubiquitin ligase Cbl-b and obesity-induced insulin resistance [Review] by Abe, Tomoki, Hirasaka, Katsuya, Kohno, Shohei, Ochi, Arisa, Yamagishi, Naoko, Ohno, Ayako, Teshima-Kondo, Shigetada, Nikawa, Takeshi

“…Obesity causes type 2 diabetes, atherosclerosis and cardiovascular diseases by inducing systemic insulin resistance. It is now recognized that obesity is…”
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Blood vessels expressing CD90 in human and rat brain tumors by Inoue, Akihiro, Tanaka, Junya, Takahashi, Hisaaki, Kohno, Shohei, Ohue, Shiro, Umakoshi, Akihiro, Gotoh, Katsuhiro, Ohnishi, Takanori

“…Blood vessels in brain tumors, particularly glioblastomas, have been shown to express CD90. CD90+ cells in and around blood vessels in cancers including brain…”
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Clinical utility of new three-dimensional model using a zero-echo-time sequence in endoscopic endonasal transsphenoidal surgery by Inoue, Akihiro, Kohno, Shohei, Nishida, Naoya, Suehiro, Satoshi, Matsumoto, Shirabe, Nishikawa, Masahiro, Ozaki, Saya, Nakamura, Yawara, Shigekawa, Seiji, Watanabe, Hideaki, Senba, Hidenori, Matsuura, Bunzo, Ohnishi, Takanori, Kunieda, Takeharu

“…•Zero-echo-time based MRI has been suggested as a new bone identification technique.•3D-MRI model based on ZTE sequence allows distinct visualization of vital…”
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Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis by Nowinski, Sara M., Solmonson, Ashley, Rundhaug, Joyce E., Rho, Okkyung, Cho, Jiyoon, Lago, Cory U., Riley, Christopher L., Lee, Sunhee, Kohno, Shohei, Dao, Christine K., Nikawa, Takeshi, Bratton, Shawn B., Wright, Casey W., Fischer, Susan M., DiGiovanni, John, Mills, Edward M.

“…To support growth, tumour cells reprogramme their metabolism to simultaneously upregulate macromolecular biosynthesis while maintaining energy production…”
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Met-PET uptake index for total tumor resection: identification of 11C-methionine uptake index as a goal for total tumor resection including infiltrating tumor cells in glioblastoma by Inoue, Akihiro, Ohnishi, Takanori, Kohno, Shohei, Ohue, Shiro, Nishikawa, Masahiro, Suehiro, Satoshi, Matsumoto, Shirabe, Ozaki, Saya, Fukushima, Mana, Kurata, Mie, Kitazawa, Riko, Shigekawa, Seiji, Watanabe, Hideaki, Kunieda, Takeharu

“…Glioblastoma multiforme (GBM) is largely due to glioma stem cells (GSCs) that escape from total resection of gadolinium (Gd)-enhanced tumor on MRI. The aim of…”
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Oct-3/4 modulates the drug-resistant phenotype of glioblastoma cells through expression of ATP binding cassette transporter G2 by Hosokawa, Yuki, Takahashi, Hisaaki, Inoue, Akihiro, Kawabe, Yuya, Funahashi, Yu, Kameda, Kenji, Sugimoto, Kana, Yano, Hajime, Harada, Hironobu, Kohno, Shohei, Ohue, Shiro, Ohnishi, Takanori, Tanaka, Junya

“…Drug resistance is a major obstacle for the efficacy of chemotherapeutic treatment of tumors. Oct-3/4, a self-renewal regulator in stem cells, is expressed in…”
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