Search Results - "KOHNO, Masakazu"

Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects by Fukui, Toshiki, Yamauchi, Kazuhiro, Maruyama, Mie, Yasuda, Tadashi, Kohno, Masakazu, Abe, Youichi

“…In recent years, oxidative stress has been postulated to be an important factor in the pathogenesis and development of lifestyle-related diseases. In this…”
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A sodium-glucose co-transporter 2 inhibitor empagliflozin prevents abnormality of circadian rhythm of blood pressure in salt-treated obese rats by Takeshige, Yui, Fujisawa, Yoshihide, Rahman, Asadur, Kittikulsuth, Wararat, Nakano, Daisuke, Mori, Hirohito, Masaki, Tsutomu, Ohmori, Koji, Kohno, Masakazu, Ogata, Hiroaki, Nishiyama, Akira

“…Studies were performed to examine the effects of the selective sodium-glucose co-transporter 2 (SGLT2) inhibitor empagliflozin on urinary sodium excretion and…”
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The cyclin-dependent kinase inhibitor p21 is essential for the beneficial effects of renal ischemic preconditioning on renal ischemia/reperfusion injury in mice by Nishioka, Satoshi, Nakano, Daisuke, Kitada, Kento, Sofue, Tadashi, Ohsaki, Hiroyuki, Moriwaki, Kumiko, Hara, Taiga, Ohmori, Koji, Kohno, Masakazu, Nishiyama, Akira

“…The cyclin-dependent kinase inhibitor p21 plays important roles in chronic renal disorders; however, its roles in response to acute renal stress are unclear…”
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Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients by Masugata, Hisashi, Senda, Shoichi, Murao, Koji, Inukai, Michio, Hosomi, Naohisa, Iwado, Yasuyoshi, Noma, Takahisa, Kohno, Masakazu, Himoto, Takashi, Goda, Fuminori

“…Although visit-to-visit variability in systolic blood pressure (SBP) has recently been demonstrated to be a strong predictor of stroke, there are no data about…”
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Effect of dipeptidyl peptidase-4 inhibition on circadian blood pressure during the development of salt-dependent hypertension in rats by Sufiun, Abu, Rafiq, Kazi, Fujisawa, Yoshihide, Rahman, Asadur, Mori, Hirohito, Nakano, Daisuke, Kobori, Hiroyuki, Ohmori, Koji, Masaki, Tsutomu, Kohno, Masakazu, Nishiyama, Akira

“…A growing body of evidence has indicated that dipeptidyl peptidase-4 (DPP-4) inhibitors have antihypertensive effects. Here, we aim to examine the effect of…”
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Aldosterone Suppresses Insulin Signaling Via the Downregulation of Insulin Receptor Substrate-1 in Vascular Smooth Muscle Cells by Hitomi, Hirofumi, Kiyomoto, Hideyasu, Nishiyama, Akira, Hara, Taiga, Moriwaki, Kumiko, Kaifu, Kumiko, Ihara, Genei, Fujita, Yoshiko, Ugawa, Toyomu, Kohno, Masakazu

“…Clinical reports indicate that patients with primary aldosteronism commonly have impaired glucose tolerance; however, the relationship between aldosterone and…”
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Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3 by Moritoki, Masahiro, Kadowaki, Takeshi, Niki, Toshiro, Nakano, Daisuke, Soma, Genichiro, Mori, Hirohito, Kobara, Hideki, Masaki, Tsutomu, Kohno, Masakazu, Hirashima, Mitsuomi

“…Galectin-9 ameliorates various murine autoimmune disease models by regulating T cells and macrophages, although it is not known what role it may have in B…”
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Hemodialysis Arteriovenous Fistula Created From the Posterior Tibial Artery and a Saphenous Vein Branch by Hara, Taiga, MD, PhD, Sofue, Tadashi, MD, PhD, Kohno, Masakazu, MD, PhD

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Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor by Sherajee, Shamshad J, Fujita, Yoshiko, Rafiq, Kazi, Nakano, Daisuke, Mori, Hirohito, Masaki, Tsutomu, Hara, Taiga, Kohno, Masakazu, Nishiyama, Akira, Hitomi, Hirofumi

“…OBJECTIVE—We previously showed that aldosterone induces insulin resistance in rat vascular smooth muscle cells (VSMCs). Because insulin-like growth factor-1…”
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Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity by Hashimoto, Takeshi, Igarashi, Junsuke, Hasan, Arif U, Ohmori, Koji, Kohno, Masakazu, Nagai, Yukiko, Yamashita, Tetsuo, Kosaka, Hiroaki

“…The steroid receptor antagonist mifepristone is used as an anti-cancer agent, eliciting both cytostatic and cytotoxic effects on malignant cells. However, the…”
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Regression of glomerular and tubulointerstitial injuries by dietary salt reduction with combination therapy of angiotensin II receptor blocker and calcium channel blocker in Dahl salt-sensitive rats by Rafiq, Kazi, Nishiyama, Akira, Konishi, Yoshio, Morikawa, Takashi, Kitabayashi, Chizuko, Kohno, Masakazu, Masaki, Tsutomu, Mori, Hirohito, Kobori, Hiroyuki, Imanishi, Masahito

“…A growing body of evidence indicates that renal tissue injuries are reversible. We investigated whether dietary salt reduction with the combination therapy of…”
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Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes: a role for inverse agonism of the angiotensin II type 1 receptor in obesity by Hasan, Arif U, Ohmori, Koji, Hashimoto, Takeshi, Kamitori, Kazuyo, Yamaguchi, Fuminori, Ishihara, Yasuhiro, Ishihara, Naoko, Noma, Takahisa, Tokuda, Masaaki, Kohno, Masakazu

“…Angiotensin (Ang) II receptor blockers (ARBs) alleviate obesity-related insulin resistance, which suggests an important role for the Ang II type 1 receptor…”
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Possible Contributions of Reactive Oxygen Species and Mitogen-Activated Protein Kinase to Renal Injury in Aldosterone/Salt-Induced Hypertensive Rats by Nishiyama, Akira, Yao, Li, Nagai, Yukiko, Miyata, Kayoko, Yoshizumi, Masanori, Kagami, Shoji, Kondo, Shuji, Kiyomoto, Hideyasu, Shokoji, Takatomi, Kimura, Shoji, Kohno, Masakazu, Abe, Youichi

“…ABSTRACT—Studies were performed to test the hypothesis that reactive oxygen species (ROS) and mitogen-activated protein kinase (MAPK) contribute to the…”
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Prognostic Value of Circulating Regulatory T Cells for Worsening Heart Failure in Heart Failure Patients With Reduced Ejection Fraction by Okamoto, Naoko, Noma, Takahisa, Ishihara, Yasuhiro, Miyauchi, Yuka, Takabatake, Wataru, Oomizu, Souichi, Yamaoka, Genji, Ishizawa, Makoto, Namba, Tsunetatsu, Murakami, Kazushi, Iwado, Yasuyoshi, Ohmori, Koji, Kohno, Masakazu

“…Regulatory T cells (Tregs) play a crucial role in the negative regulation of immune responses. Recent studies suggest that Tregs are involved in the…”
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Regulator of G-Protein Signaling Subtype 4 Mediates Antihypertrophic Effect of Locally Secreted Natriuretic Peptides in the Heart by TOKUDOME, Takeshi, KISHIMOTO, Ichiro, NAKAO, Kazuwa, KANGAWA, Kenji, HORIO, Takeshi, ARAI, Yuji, SCHWENKE, Daryl O, HINO, Jun, OKANO, Ichiro, KAWANO, Yuhei, KOHNO, Masakazu, MIYAZATO, Mikiya

“…Mice lacking guanylyl cyclase-A (GC-A), a natriuretic peptide receptor, have pressure-independent cardiac hypertrophy. However, the mechanism underlying…”
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Alpha2-macroglobulin as a promising biomarker for cerebral small vessel disease in acute ischemic stroke patients by Nezu, Tomohisa, Hosomi, Naohisa, Aoki, Shiro, Deguchi, Kazushi, Masugata, Hisashi, Ichihara, Noriko, Ohyama, Hideo, Ohtsuki, Toshiho, Kohno, Masakazu, Matsumoto, Masayasu

“…Alpha2-macroglobulin is a protease inhibitor that enhances procoagulant properties via the neutralization of plasmin, plasminogen activators and…”
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Systemic candesartan reduces brain angiotensin II via downregulation of brain renin-angiotensin system by Pelisch, Nicolas, Hosomi, Naohisa, Ueno, Masaki, Masugata, Hisashi, Murao, Koji, Hitomi, Hirofumi, Nakano, Daisuke, Kobori, Hiroyuki, Nishiyama, Akira, Kohno, Masakazu

“…The renin-angiotensin system has an important function in the regulation of blood pressure as well as in pathophysiological processes in the central nervous…”
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Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats by Rafiq, Kazi, Nakano, Daisuke, Ihara, Genei, Hitomi, Hirofumi, Fujisawa, Yoshihide, Ohashi, Naro, Kobori, Hiroyuki, Nagai, Yukiko, Kiyomoto, Hideyasu, Kohno, Masakazu, Nishiyama, Akira

“…OBJECTIVESAldosterone is well recognized as the selective physiological ligand for mineralocorticoid receptor in epithelia. However, in-vitro studies have…”
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Aldosterone Stimulates Collagen Gene Expression and Synthesis Via Activation of ERK1/2 in Rat Renal Fibroblasts by Nagai, Yukiko, Miyata, Kayoko, Sun, Guang-Ping, Rahman, Matlubur, Kimura, Shoji, Miyatake, Akira, Kiyomoto, Hideyasu, Kohno, Masakazu, Abe, Youichi, Yoshizumi, Masanori, Nishiyama, Akira

“…Recently, we demonstrated that in rats treated chronically with aldosterone and salt, severe tubulointerstitial fibrosis is associated with the activation of…”
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Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development by Tokudome, Takeshi, Kishimoto, Ichiro, Shindo, Takayuki, Kawakami, Hayato, Koyama, Teruhide, Otani, Kentaro, Nishimura, Hirohito, Miyazato, Mikiya, Kohno, Masakazu, Nakao, Kazuwa, Kangawa, Kenji

“…Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) bind to the receptor guanylyl cyclase (GC)-A, leading to diuresis, natriuresis, and blood…”
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