Search Results - "KOHN, T. J"

Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restricted C3-side chain of hydroxybenzo[ b]thiophenes by Takeuchi, Kumiko, Kohn, Todd J., Sall, Daniel J., Denney, Michael L., McCowan, Jefferson R., Smith, Gerry F., Gifford-Moore, Donetta S.

“…A novel series of benzo[ b]thiophene diamine thrombin inhibitors with a conformationally restricted C3-side chain 3 was investigated. The constrained C3-side…”
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Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding Orientation by Sall, Daniel J, Bastian, Jolie A, Briggs, Stephen L, Buben, John A, Chirgadze, Nickolay Y, Clawson, David K, Denney, Michael L, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Hauser, Kenneth L, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Smith, Gerald F, Takeuchi, Kumiko, Thrasher, Kenneth J, Tinsley, Jennifer M, Utterback, Barbara G, Yan, Sau-Chi B, Zhang, Minsheng

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Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 5. Potency, Efficacy, and Pharmacokinetic Properties of Modified C-3 Side Chain Derivatives by Sall, Daniel J, Bailey, Dianna L, Bastian, Jolie A, Buben, John A, Chirgadze, Nickolay Y, Clemens-Smith, Amy C, Denney, Michael L, Fisher, Matthew J, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Johnson, Lea M, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Richett, Michael E, Smith, Gerald F, Snyder, David W, Takeuchi, Kumiko, Toth, John E, Zhang, Minsheng

“…A systematic investigation of the structure−activity relationships of the C-3 side chain of the screening hit 1a led to the identification of the potent…”
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Development of Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase Inhibition. 3. Synthesis and Biological Activities of Oxazolecarboxamide-Substituted ω-Phenyl-ω-(3-pyridyl)alkenoic Acid Derivatives and Related Compounds by Takeuchi, Kumiko, Kohn, Todd J, True, Timothy A, Mais, Dale E, Wikel, James H, Utterback, Barbara G, Wyss, Virginia L, Jakubowski, Joseph A

“…A novel series of oxazolecarboxamide-substituted ω-phenyl-ω-(3-pyridyl)alkenoic acid derivatives was discovered as potent dual-acting agents to block the TXA2…”
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Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4'-side chain analogues by TAKEUCHI, K, KOHN, T. J, HARPER, R. W, LIN, H.-S, GIFFORD-MOORE, D. S, RICHETT, M. E, SALL, D. J, SMITH, G. F, MINSHENG ZHANG

“…Novel benzo[b]thiophene diamine thrombin inhibitors were investigated, focusing on a contracted C4'-side chain series. SAR studies identified compounds with…”
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Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives by Takeuchi, Kumiko, Kohn, Todd J, Mais, Dale E, True, Timothy A, Wyss, Virginia L, Jakubowski, Joseph A

“…Synthesis and initial in vitro evaluation of a novel series of phenyl oxazole derivatives are described. An SAR study of the novel dual-acting TRA/TSI agent…”
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Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2: sidechain optimization and demonstration of in vivo efficacy by Zhang, Minsheng, Bailey, Dianna L., Bastian, Jolie A., Briggs, Stephen L., Chirgadze, Nickolay Y., Clawson, David K., Denney, Michael L., Gifford-Moore, Donetta S., Harper, Richard W., Johnson, Lea M., Klimkowski, Valentine J., Kohn, Todd J., Lin, Ho-Shen, McCowan, Jefferson R., Richett, Michael E., Sall, Daniel J., Smith, Amy J., Smith, Gerald F., Snyder, David W., Takeuchi, Kumiko, Utterback, Barbara G., Yan, Sau-Chi B.

“…Potent, subnanomolar thrombin inhibitors 4, 5, and 6 are developed through side chain optimization of novel, benzo[ b]thiophene-based small organic entities 2…”
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Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4 by ROCCO, Vincent P, SPINAZZE, Patrick G, TAKEUCHI, Kumiko, KOHN, Todd J, HONIGSCHMIDT, Nicholas A, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T

“…A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was…”
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Advances toward new antidepressants beyond SSRIs : 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5 by TAKEUCHI, Kumiko, KOHN, Todd J, LODGE, David, MARTIN, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, HEMRICK-LUECKE, Susan K, THOMPSON, Linda K, EVANS, David C, RASMUSSEN, Kurt, KOGER, Deanna

“…A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered…”
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Advances toward new antidepressants beyond SSRIs: 1-Aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1 by TAKEUCHI, Kumiko, KOHN, Todd J, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, KOCH, Daniel J, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J, SHAW, Janice

“…A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered…”
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Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3 by TAKEUCHI, Kumiko, KOHN, Todd J, SHAW, Janice, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, ATKINSON, Steven T, HERTEL, Larry W, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J

“…A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered…”
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Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 2 by TAKEUCHI, Kumiko, KOHN, Todd J, AHMAD, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T, HONIGSCHMIDT, Nicholas A, ROCCO, Vincent P, SPINAZZE, Patrick G, KOCH, Daniel J, ATKINSON, Steven T, HERTEL, Larry W, NELSON, David L, WAINSCOTT, D. Bradley

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