Search Results - "KOHN, Leonard D"

Wnt5a is expressed in murine and human atherosclerotic lesions by Christman, 2nd, Mark A, Goetz, Douglas J, Dickerson, Eric, McCall, Kelly D, Lewis, Christopher J, Benencia, Fabian, Silver, Mitchell J, Kohn, Leonard D, Malgor, Ramiro

“…Atherosclerosis is an inflammatory disease involving the accumulation of macrophages in the intima. Wnt5a is a noncanonical member of the Wnt family of…”
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Differential regulation of apical and basal iodide transporters in the thyroid by thyroglobulin by Suzuki, Koichi, Kohn, Leonard D

“…We have shown that thyroglobulin (Tg) is a potent autocrine regulator of thyroid-specific gene expression, and proposed that the accumulated follicular Tg…”
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Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages by McCall, Kelly D, Holliday, Dawn, Dickerson, Eric, Wallace, Brian, Schwartz, Anthony L, Schwartz, Christopher, Lewis, Christopher J, Kohn, Leonard D, Schwartz, Frank L

“…Visceral adipocytes and associated macrophages produce and release excessive amounts of biologically active inflammatory cytokines via the portal and systemic…”
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Thyroglobulin (Tg) induces thyroid cell growth in a concentration-specific manner by a mechanism other than thyrotropin/cAMP stimulation by Noguchi, Yoshihiko, Harii, Norikazu, Giuliani, Cesidio, Tatsuno, Ichiro, Suzuki, Koichi, Kohn, Leonard D.

“…Thyroglobulin (Tg), a major product of the thyroid gland, serves as a macromolecular precursor of thyroid hormone biosynthesis. In addition, Tg stored in the…”
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Phenylmethimazole Decreases Toll-Like Receptor 3 and Noncanonical Wnt5a Expression in Pancreatic Cancer and Melanoma Together with Tumor Cell Growth and Migration by Schwartz, Anthony L, Malgor, Ramiro, Dickerson, Eric, Weeraratna, Ashani T, Slominski, Andrzej, Wortsman, Jacobo, Harii, Norikazu, Kohn, Aimee D, Moon, Randall T, Schwartz, Frank L, Goetz, Douglas J, Kohn, Leonard D, McCall, Kelly D

“…Purpose: To evaluate whether ( a ) Wnt5a expression in pancreatic cancer and malignant melanoma cells might be associated with constitutive levels of Toll-like…”
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Propylthiouracil increases sodium/iodide symporter gene expression and iodide uptake in rat thyroid cells in the absence of TSH by Sue, Mariko, Akama, Takeshi, Kawashima, Akira, Nakamura, Hannah, Hara, Takeshi, Tanigawa, Kazunari, Wu, Huhehasi, Yoshihara, Aya, Ishido, Yuko, Hiroi, Naoki, Yoshino, Gen, Kohn, Leonard D, Ishii, Norihisa, Suzuki, Koichi

“…Propylthiouracil (PTU) and methimazole (MMI) are drugs that are widely used to treat Graves' disease. Although both exert an antithyroid effect primarily by…”
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Role of the Asialoglycoprotein Receptor in Binding and Entry of Hepatitis C Virus Structural Proteins in Cultured Human Hepatocytes by Saunier, Bertrand, Triyatni, Miriam, Ulianich, Luca, Maruvada, Padma, Yen, Paul, Kohn, Leonard D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Genomic DNA Released by Dying Cells Induces the Maturation of APCs by Ishii, Ken J, Suzuki, Koichi, Coban, Cevayir, Takeshita, Fumihiko, Itoh, Yasushi, Matoba, Hana, Kohn, Leonard D, Klinman, Dennis M

“…Mature APCs play a key role in the induction of Ag-specific immunity. This work examines whether genomic DNA released by dying cells provides a stimulus for…”
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Pendrin Is an Iodide-Specific Apical Porter Responsible for Iodide Efflux from Thyroid Cells by Yoshida, Akio, Taniguchi, Shinichi, Hisatome, Ichiro, Royaux, Ines E., Green, Eric D., Kohn, Leonard D., Suzuki, Koichi

“…The Pendred syndrome gene encodes a 780-amino acid putative transmembrane protein (pendrin) that is expressed in the apical membrane of thyroid follicular…”
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Regulation of major histocompatibility complex gene expression in thyroid epithelial cells by methimazole and phenylmethimazole by Giuliani, Cesidio, Bucci, Ines, Montani, Valeria, Singer, Dinah S, Monaco, Fabrizio, Kohn, Leonard D, Napolitano, Giorgio

“…Increased expression of major histocompatibility complex (MHC) class-I genes and aberrant expression of MHC class-II genes in thyroid epithelial cells (TECs)…”
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Mechanism of Iodide/Chloride Exchange by Pendrin by Yoshida, Akio, Hisatome, Ichiro, Taniguchi, Shinichi, Sasaki, Norihiro, Yamamoto, Yasutaka, Miake, Junichiro, Fukui, Hiroko, Shimizu, Hideki, Okamura, Tomohisa, Okura, Tsuyoshi, Igawa, Osamu, Shigemasa, Chiaki, Green, Eric D, Kohn, Leonard D, Suzuki, Koichi

“…We performed an electrophysiological study to investigate ion transport of pendrin and thereby understand the pathogenesis of Pendred syndrome. Using…”
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Interaction of Hepatitis C Virus-Like Particles and Cells: a Model System for Studying Viral Binding and Entry by Triyatni, Miriam, Saunier, Bertrand, Maruvada, Padma, Davis, Anthony R, Ulianich, Luca, Heller, Theo, Patel, Arvind, Kohn, Leonard D, Liang, T Jake

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms by Kim, Won Bae, Lewis, Christopher J, McCall, Kelly D, Malgor, Ramiro, Kohn, Aimee D, Moon, Randall T, Kohn, Leonard D

“…Wnt binding to cell surface receptors can activate a ‘canonical’ pathway that increases cellular β-catenin or a ‘noncanonical’ Ca++ pathway which can increase…”
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TGF-β-like Transcriptional Effects of Thyroglobulin (Tg) in Mouse Mesangial Cells by SELLITTI, Donald F., PUGGINA, Enrico, LAGRANHA, Claudia, DOI, Sonia Q., PITHON-CURI, Tania, KOHN, Leonard D., SUZUKI, Koichi

“…TGF-β-like activities of proteins unrelated to the cytokine could mimic its actions in fibrosis and cell proliferation. Thyroglobulin (Tg) has been identified…”
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Thyrotropin Receptor Autoantibodies (TSHRAbs): Epitopes, Origins and Clinical Significance by Kohn, Leonard D., Harii, Norikazu

“…Epitopes for >95% stimulating thyrotropin receptor autoantibodies (TSHRAbs) causally implicated in Graves' disease (Basedow's disease or primary…”
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A TSHR-LH/CGR Chimera that Measures Functional Thyroid-Stimulating Autoantibodies (TSAb) Can Predict Remission or Recurrence in Graves' Patients Undergoing Antithyroid Drug (ATD) Treatment by Giuliani, Cesidio, Cerrone, Dominique, Harii, Norikazu, Thornton, Mark, Kohn, Leonard D, Dagia, Nilesh M, Bucci, Ines, Carpentieri, Maria, Di Nenno, Barbara, Di Blasio, Andrea, Vitti, Paolo, Monaco, Fabrizio, Napolitano, Giorgio

“…Context: A functional thyroid-stimulating autoantibodies (TSAb) assay using a thyroid-stimulating hormone receptor chimera (Mc4) appears to be clinically more…”
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Effects of thyroglobulin and pendrin on iodide flux through the thyrocyte by Kohn, Leonard D, Suzuki, Koichi, Nakazato, Minoru, Royaux, Ines, Green, Eric D

“…Iodide transport by thyrocytes involves porters on the apical and basal surfaces of the cell facing the follicular lumen and bloodstream, respectively. Recent…”
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A TSHr-LH/CGr Chimera that Measures Functional TSAb in Graves' Disease by Giuliani, Cesidio, Cerrone, Dominique, Harii, Norikazu, Thornton, Mark, Kohn, Leonard D, Dagia, Nilesh M, Fiore, Emilio, Bucci, Ines, Chamblin, Tyler, Vitti, Paolo, Monaco, Fabrizio, Napolitano, Giorgio

“…Context: Stimulating thyrotropin receptor (TSHr) autoantibodies (TSAb) are the cause of hyperthyroidism in Graves' disease. In a patient's serum, TSAb can…”
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Overexpression and overactivation of Akt in thyroid carcinoma by RINGEL, Matthew D, HAYRE, Nicole, SAITO, Jun, SAUNIER, Bertrand, SCHUPPERT, Frank, BURCH, Henry, BERNET, Victor, BURMAN, Kenneth D, KOHN, Leonard D, SAJI, Motoyasu

“…Enhanced activation of Akt occurs in Cowden's disease, an inherited syndrome of follicular thyroid, breast, colon, and skin tumors, via inactivation of its…”
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The Flavonoid Quercetin Regulates Growth and Gene Expression in Rat FRTL-5 Thyroid Cells by Giuliani, Cesidio, Noguchi, Yoshihiko, Harii, Norikazu, Napolitano, Giorgio, Tatone, Dante, Bucci, Ines, Piantelli, Mauro, Monaco, Fabrizio, Kohn, Leonard D

“…Quercetin is the most consumed flavonoid present in fruits and vegetables. There has been increased interest in the possible health benefits of quercetin and…”
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