Search Results - "KOHARA, Yuji"
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Platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions
Published in Nature communications (12-04-2019)“…The ultimate goal for diploid genome determination is to completely decode homologous chromosomes independently, and several phasing programs from consensus…”
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2
Reconstruction of the vertebrate ancestral genome reveals dynamic genome reorganization in early vertebrates
Published in Genome Research (01-09-2007)“…Although several vertebrate genomes have been sequenced, little is known about the genome evolution of early vertebrates and how large-scale genomic changes…”
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3
A small RNA system ensures accurate homologous pairing and unpaired silencing of meiotic chromosomes
Published in The EMBO journal (01-06-2023)“…During meiosis, chromosomes with homologous partners undergo synaptonemal complex (SC)‐mediated pairing, while the remaining unpaired chromosomes are…”
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4
Efficient de novo assembly of highly heterozygous genomes from whole-genome shotgun short reads
Published in Genome research (01-08-2014)“…Although many de novo genome assembly projects have recently been conducted using high-throughput sequencers, assembling highly heterozygous diploid genomes is…”
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5
Co-option of Sox3 as the male-determining factor on the Y chromosome in the fish Oryzias dancena
Published in Nature communications (20-06-2014)“…Sex chromosomes harbour a primary sex-determining signal that triggers sexual development of the organism. However, diverse sex chromosome systems have been…”
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Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein
Published in Nature communications (20-09-2016)“…Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade species tolerate almost complete dehydration and exhibit extraordinary…”
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7
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
Published in Nature (22-05-2008)“…RNA interference (RNAi) is a mechanism by which double-stranded RNAs (dsRNAs) suppress specific transcripts in a sequence-dependent manner. dsRNAs are…”
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8
A whole-mount in situ hybridization method for microRNA detection in Caenorhabditis elegans
Published in RNA (Cambridge) (01-07-2016)“…Whole-mount in situ hybridization (WISH) is an outstanding method to decipher the spatiotemporal expression patterns of microRNAs (miRNAs) and provides…”
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9
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse
Published in Human molecular genetics (01-10-2007)“…DNA methylation is an important epigenetic modification regulating various biological phenomena, including genomic imprinting and transposon silencing. It is…”
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10
Genome sequence and analysis of the Japanese morning glory Ipomoea nil
Published in Nature communications (08-11-2016)“…Ipomoea is the largest genus in the family Convolvulaceae. Ipomoea nil (Japanese morning glory) has been utilized as a model plant to study the genetic basis…”
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11
The amphioxus genome and the evolution of the chordate karyotype
Published in Nature (19-06-2008)“…Lancelets (‘amphioxus’) are the modern survivors of an ancient chordate lineage, with a fossil record dating back to the Cambrian period. Here we describe the…”
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12
Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18 in C. elegans
Published in Developmental biology (15-03-2015)“…A wide variety of cells are generated by the expression of characteristic sets of genes, primarily those regulated by cell-specific transcription. To elucidate…”
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13
Large-scale analysis of full-length cDNAs from the tomato (Solanum lycopersicum) cultivar Micro-Tom, a reference system for the Solanaceae genomics
Published in BMC genomics (30-03-2010)“…The Solanaceae family includes several economically important vegetable crops. The tomato (Solanum lycopersicum) is regarded as a model plant of the Solanaceae…”
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Genome analysis of Diploscapter coronatus: insights into molecular peculiarities of a nematode with parthenogenetic reproduction
Published in BMC genomics (24-06-2017)“…Sexual reproduction involving the fusion of egg and sperm is prevailing among eukaryotes. In contrast, the nematode Diploscapter coronatus, a close relative of…”
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Mutations in cell elongation genes mreB, mrdA and mrdB suppress the shape defect of RodZ‐deficient cells
Published in Molecular microbiology (01-03-2013)“…Summary RodZ interacts with MreB and both factors are required to maintain the rod shape of Escherichia coli. The assembly of MreB into filaments regulates the…”
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16
Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi
Published in Current biology (06-02-2001)“…Genome-wide analysis of gene function is essential for the post-genome era, and development of efficient and economical technology suitable for it has been in…”
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The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains
Published in Genome research (01-08-2013)“…Commonly used classical inbred mouse strains have mosaic genomes with sequences from different subspecific origins. Their genomes are derived predominantly…”
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18
Axial patterning in cephalochordates and the evolution of the organizer
Published in Nature (08-02-2007)“…The organizer of the vertebrate gastrula is an important signalling centre that induces and patterns dorsal axial structures. Although a topic of long-standing…”
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Identification of genes expressed in the hermaphrodite germ line of C. elegans using SAGE
Published in BMC genomics (09-05-2009)“…Germ cells must progress through elaborate developmental stages from an undifferentiated germ cell to a fully differentiated gamete. Some of these stages…”
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TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
Published in Nature immunology (01-05-2004)“…Both plants and animals respond to infection by synthesizing compounds that directly inhibit or kill invading pathogens. We report here the identification of…”
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