Search Results - "KOH, Amy J"

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone by Roca, Hernan, Jones, Jacqueline D, Purica, Marta C, Weidner, Savannah, Koh, Amy J, Kuo, Robert, Wilkinson, John E, Wang, Yugang, Daignault-Newton, Stephanie, Pienta, Kenneth J, Morgan, Todd M, Keller, Evan T, Nör, Jacques E, Shea, Lonnie D, McCauley, Laurie K

“…During tumor progression, immune system phagocytes continually clear apoptotic cancer cells in a process known as efferocytosis. However, the impact of…”
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Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone by Cho, Sun Wook, Soki, Fabiana N., Koh, Amy J., Eber, Matthew R., Entezami, Payam, In Park, Serk, van Rooijen, Nico, McCauley, Laurie K.

“…Cellular subpopulations in the bone marrow play distinct and unexplored functions in skeletal homeostasis. This study delineated a unique role of osteal…”
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Polarization of Prostate Cancer-associated Macrophages Is Induced by Milk Fat Globule-EGF Factor 8 (MFG-E8)-mediated Efferocytosis by Soki, Fabiana N., Koh, Amy J., Jones, Jacqueline D., Kim, Yeo Won, Dai, Jinlu, Keller, Evan T., Pienta, Kenneth J., Atabai, Kamran, Roca, Hernan, McCauley, Laurie K.

“…Tumor cells secrete factors that modulate macrophage activation and polarization into M2 type tumor-associated macrophages, which promote tumor growth,…”
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Modulation of Osteoblastic Cell Efferocytosis by Bone Marrow Macrophages by Michalski, Megan N., Koh, Amy J., Weidner, Savannah, Roca, Hernan, McCauley, Laurie K.

“…ABSTRACT Apoptosis occurs at an extraordinary rate in the human body and the effective clearance of dead cells (efferocytosis) is necessary to maintain…”
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Caspase-9 driven murine model of selective cell apoptosis and efferocytosis by Batoon, Lena, Koh, Amy J., Kannan, Rahasudha, McCauley, Laurie K., Roca, Hernan

“…Apoptosis and efficient efferocytosis are integral to growth, development, and homeostasis. The heterogeneity of these mechanisms in different cells across…”
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Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2 by McCauley, Laurie K, Dalli, Jesmond, Koh, Amy J, Chiang, Nan, Serhan, Charles N

“…Bone marrow macrophages stimulate skeletal wound repair and osteoblastic bone formation by poorly defined mechanisms. Specialized proresolving mediators of…”
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Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone by Al-Dujaili, Saja A., Koh, Amy J., Dang, Ming, Mi, Xue, Chang, Wenhan, Ma, Peter X., McCauley, Laurie K.

“…ABSTRACT Anabolic actions of PTH in bone involve increased deposition of mineralizing matrix. Regulatory feedback of the process may be important to maintain…”
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Bone marrow macrophages support prostate cancer growth in bone by Soki, Fabiana N, Cho, Sun Wook, Kim, Yeo Won, Jones, Jacqueline D, Park, Serk In, Koh, Amy J, Entezami, Payam, Daignault-Newton, Stephanie, Pienta, Kenneth J, Roca, Hernan, McCauley, Laurie K

“…Resident macrophages in bone play important roles in bone remodeling, repair, and hematopoietic stem cell maintenance, yet their role in skeletal metastasis…”
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Skeletal Localization and Neutralization of the SDF‐1(CXCL12)/CXCR4 Axis Blocks Prostate Cancer Metastasis and Growth in Osseous Sites In Vivo by Sun, Yan‐Xi, Schneider, Abraham, Jung, Younghun, Wang, Jianhua, Dai, Jinlu, Wang, Jingcheng, Cook, Kevin, Osman, Nadir I, Koh‐Paige, Amy J, Shim, Hyusuk, Pienta, Kenneth J, Keller, Evan T, McCauley, Laurie K, Taichman, Russell S

“…To delineate the role of SDF‐1 and CXCR4 in metastatic prostate cancer (CaP), positive correlations were established between SDF‐1 levels and tumor metastasis…”
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Tumor expressed PTHrP facilitates prostate cancer‐induced osteoblastic lesions by Liao, Jinhui, Li, Xin, Koh, Amy J., Berry, Janice E., Thudi, Nanda, Rosol, Thomas J., Pienta, Kenneth J., McCauley, Laurie K.

“…Expression of parathyroid hormone‐related protein (PTHrP) correlates with prostate cancer skeletal progression; however, the impact of prostate cancer‐derived…”
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Cyclin D1 as a Target for the Proliferative Effects of PTH and PTHrP in Early Osteoblastic Cells by Datta, Nabanita S, Pettway, Glenda J, Chen, Chen, Koh, Amy J, McCauley, Laurie K

“…PTHrP induced a proliferative cyclin D1 activation in low‐density osteoblastic cells. The process was PKA and MAPK dependent and involved both AP‐1 and CRE…”
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Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation by Pettway, Glenda J, Meganck, Jeffrey A, Koh, Amy J, Keller, Evan T, Goldstein, Steven A, McCauley, Laurie K

“…Abstract PTH (1–34) is the only FDA-approved anabolic agent for osteoporosis treatment in the U.S., but its mechanisms are not completely understood. This…”
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Unique Pro-Inflammatory Response of Macrophages during Apoptotic Cancer Cell Clearance by Mendoza-Reinoso, Veronica, Baek, Dah Youn, Kurutz, Adrianne, Rubin, John R, Koh, Amy J, McCauley, Laurie K, Roca, Hernan

“…The clearance of apoptotic cells by macrophages (efferocytosis) is crucial to maintain normal tissue homeostasis; however, efferocytosis of cancer cells…”
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Cells of the Osteoclast Lineage as Mediators of the Anabolic Actions of Parathyroid Hormone in Bone by Koh, Amy J, Demiralp, Burak, Neiva, Kathleen G, Hooten, Joanna, Nohutcu, Rahime M, Shim, Hyunsuk, Datta, Nabanita S, Taichman, Russell S, McCauley, Laurie K

“…PTH is an anabolic agent used to treat osteoporosis, but its mechanisms of action are unclear. This study elucidated target cells and mechanisms for anabolic…”
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Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6 by Pirih, Flavia Q, Michalski, Megan N, Cho, Sun W, Koh, Amy J, Berry, Janice E, Ghaname, Eduardo, Kamarajan, Pachiyappan, Bonnelye, Edith, Ross, Charles W, Kapila, Yvonne L, Jurdic, Pierre, McCauley, Laurie K

“…Parathyroid hormone (PTH) stimulates hematopoietic cells through mechanisms of action that remain elusive. Interleukin-6 (IL-6) is upregulated by PTH and…”
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Juxtacrine interaction of macrophages and bone marrow stromal cells induce interleukin-6 signals and promote cell migration by Chang, Jia, Koh, Amy J, Roca, Hernan, McCauley, Laurie K

“…The bone marrow contains a heterogeneous milieu of cells, including macrophages, which are key cellular mediators for resolving infection and inflammation…”
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Proteoglycan 4, a Novel Immunomodulatory Factor, Regulates Parathyroid Hormone Actions on Hematopoietic Cells by Novince, Chad M, Koh, Amy J, Michalski, Megan N, Marchesan, Julie T, Wang, Jason, Jung, Younghun, Berry, Janice E, Eber, Matthew R, Rosol, Thomas J, Taichman, Russell S, McCauley, Laurie K

“…Proteoglycan 4 (PRG4), a critical protective factor in articular joints, is implicated in hematopoietic progenitor cell expansion and megakaryopoiesis. PRG4…”
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Local pulsatile PTH delivery regenerates bone defects via enhanced bone remodeling in a cell-free scaffold by Dang, Ming, Koh, Amy J., Jin, Xiaobing, McCauley, Laurie K., Ma, Peter X.

“…Parathyroid hormone (PTH) is currently the only FDA-approved anabolic drug to treat osteoporosis, and is systemically administered through daily injections. A…”
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Parathyroid Hormone and Parathyroid Hormone-related Protein Exert Both Pro- and Anti-apoptotic Effects in Mesenchymal Cells by Chen, Hen-Li, Demiralp, Burak, Schneider, Abraham, Koh, Amy J., Silve, Caroline, Wang, Cun-Yu, McCauley, Laurie K.

“…During bone formation, multipotential mesenchymal cells proliferate and differentiate into osteoblasts, and subsequently many die because of apoptosis…”
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Anabolic Actions of Parathyroid Hormone during Bone Growth Are Dependent on c-fos by Demiralp, Burak, Chen, Hen-Li, Koh, Amy J, Keller, Evan T, McCauley, Laurie K

“…PTH has anabolic and catabolic actions in bone that are not clearly understood. The protooncogene c-fos and other activating protein 1 family members are…”
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