Search Results - "KOGNER, Per"

Targeting Suppressive Myeloid Cells Potentiates Checkpoint Inhibitors to Control Spontaneous Neuroblastoma by Mao, Yumeng, Eissler, Nina, Blanc, Katarina Le, Johnsen, John Inge, Kogner, Per, Kiessling, Rolf

“…Neuroblastoma is the most common extracranial solid cancer type in childhood, and high-risk patients have poor prognosis despite aggressive multimodal…”
Get full text

Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial by Ladenstein, Ruth, Prof, Pötschger, Ulrike, MSc, Pearson, Andrew D J, Prof, Brock, Penelope, MD, Luksch, Roberto, MD, Castel, Victoria, MD, Yaniv, Isaac, Prof, Papadakis, Vassilios, MD, Laureys, Geneviève, MD, Malis, Josef, MD, Balwierz, Walentyna, Prof, Ruud, Ellen, MD, Kogner, Per, Prof, Schroeder, Henrik, Prof, de Lacerda, Ana Forjaz, MD, Beck-Popovic, Maja, MD, Bician, Pavel, MD, Garami, Miklós, MD, Trahair, Toby, MD, Canete, Adela, MD, Ambros, Peter F, PhD, Holmes, Keith, MD, Gaze, Mark, MD, Schreier, Günter, PhD, Garaventa, Alberto, MD, Vassal, Gilles, Prof, Michon, Jean, MD, Valteau-Couanet, Dominique, MD

“…Summary Background High-dose chemotherapy with haemopoietic stem-cell rescue improves event-free survival in patients with high-risk neuroblastoma; however,…”
Get full text

The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation by Pandey, Gaurav Kumar, Mitra, Sanhita, Subhash, Santhilal, Hertwig, Falk, Kanduri, Meena, Mishra, Kankadeb, Fransson, Susanne, Ganeshram, Abiarchana, Mondal, Tanmoy, Bandaru, Sashidhar, Östensson, Malin, Akyürek, Levent M., Abrahamsson, Jonas, Pfeifer, Susan, Larsson, Erik, Shi, Leming, Peng, Zhiyu, Fischer, Matthias, Martinsson, Tommy, Hedborg, Fredrik, Kogner, Per, Kanduri, Chandrasekhar

“…Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low-…”
Get full text

Whole-genome sequencing of recurrent neuroblastoma reveals somatic mutations that affect key players in cancer progression and telomere maintenance by Fransson, Susanne, Martinez-Monleon, Angela, Johansson, Mathias, Sjöberg, Rose-Marie, Björklund, Caroline, Ljungman, Gustaf, Ek, Torben, Kogner, Per, Martinsson, Tommy

“…Neuroblastoma is the most common and deadly childhood tumor. Relapsed or refractory neuroblastoma has a very poor prognosis despite recent treatment advances…”
Get full text

Emergence of new ALK mutations at relapse of neuroblastoma by Schleiermacher, Gudrun, Javanmardi, Niloufar, Bernard, Virginie, Leroy, Quentin, Cappo, Julie, Rio Frio, Thomas, Pierron, Gaelle, Lapouble, Eve, Combaret, Valérie, Speleman, Frank, de Wilde, Bram, Djos, Anna, Ora, Ingrid, Hedborg, Fredrik, Träger, Catarina, Holmqvist, Britt-Marie, Abrahamsson, Jonas, Peuchmaur, Michel, Michon, Jean, Janoueix-Lerosey, Isabelle, Kogner, Per, Delattre, Olivier, Martinsson, Tommy

“…In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated the potential role of ALK mutations in neuroblastoma clonal…”
Get full text

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells by Zirath, Hanna, Frenzel, Anna, Oliynyk, Ganna, Segerström, Lova, Westermark, Ulrica K., Larsson, Karin, Persson, Matilda Munksgaard, Hultenby, Kjell, Lehtiö, Janne, Einvik, Christer, Påhlman, Sven, Kogner, Per, Jakobsson, Per-Johan, Henriksson, Marie Arsenian

“…The MYC genes are the most frequently activated oncogenes in human tumors and are hence attractive therapeutic targets. MYCN amplification leads to poor…”
Get full text

Integrative discovery of treatments for high-risk neuroblastoma by Almstedt, Elin, Elgendy, Ramy, Hekmati, Neda, Rosén, Emil, Wärn, Caroline, Olsen, Thale Kristin, Dyberg, Cecilia, Doroszko, Milena, Larsson, Ida, Sundström, Anders, Arsenian Henriksson, Marie, Påhlman, Sven, Bexell, Daniel, Vanlandewijck, Michael, Kogner, Per, Jörnsten, Rebecka, Krona, Cecilia, Nelander, Sven

“…Despite advances in the molecular exploration of paediatric cancers, approximately 50% of children with high-risk neuroblastoma lack effective treatment. To…”
Get full text

The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma by Djos, Anna, Martinsson, Tommy, Kogner, Per, Carén, Helena

“…Hypermethylation of promotor CpG islands is a common mechanism that inactivates tumor suppressor genes in cancer. Genes belonging to the RASSF gene family have…”
Get full text

COX/mPGES-1/PGE₂ pathway depicts an inflammatory-dependent high-risk neuroblastoma subset by Larsson, Karin, Kock, Anna, Idborg, Helena, Henriksson, Marie Arsenian, Martinsson, Tommy, Johnsen, John I., Korotkova, Marina, Kogner, Per, Jakobsson, Per-Johan

“…The majority of solid tumors are presented with an inflammatory microenvironment. Proinflammatory lipid mediators including prostaglandin E2 (PGE₂) contribute…”
Get full text

Pharmacological inhibition of BCL-2 with the FDA-approved drug venetoclax impairs longitudinal bone growth by Velentza, Lilly, Wickström, Malin, Kogner, Per, Ohlsson, Claes, Zaman, Farasat, Sävendahl, Lars

“…Treatment-related skeletal complications are common in childhood cancer patients and survivors. Venetoclax is a BCL-2 inhibitor that has shown efficacy in…”
Get full text

Risk stratification of high‐risk metastatic neuroblastoma: A report from the HR‐NBL‐1/SIOPEN study by Morgenstern, Daniel A., Pötschger, Ulrike, Moreno, Lucas, Papadakis, Vassilios, Owens, Cormac, Ash, Shifra, Pasqualini, Claudia, Luksch, Roberto, Garaventa, Alberto, Canete, Adela, Elliot, Martin, Wieczorek, Aleksandra, Laureys, Geneviève, Kogner, Per, Malis, Josef, Ruud, Ellen, Beck‐Popovic, Maja, Schleiermacher, Gudrun, Valteau‐Couanet, Dominique, Ladenstein, Ruth

“…Background Risk stratification is crucial to treatment decision‐making in neuroblastoma. This study aimed to explore factors present at diagnosis affecting…”
Get full text

Dual Targeting of Wild-Type and Mutant p53 by Small Molecule RITA Results in the Inhibition of N-Myc and Key Survival Oncogenes and Kills Neuroblastoma Cells In Vivo and In Vitro by BURMAKIN, Mikhail, YAO SHI, HEDSTRÖM, Elisabeth, KOGNER, Per, SELIVANOVA, Galina

“…Restoration of the p53 function in tumors is a promising therapeutic strategy due to the high potential of p53 as tumor suppressor and the fact that…”
Get full text

High-Risk Neuroblastoma Tumors with 11q-Deletion Display a Poor Prognostic, Chromosome Instability Phenotype with Later Onset by Carén, Helena, Kryh, Hanna, Nethander, Maria, Sjöberg, Rose-Marie, Träger, Catarina, Nilsson, Staffan, Abrahamsson, Jonas, Kogner, Per, Martinsson, Tommy, Klein, George

“…Analysis of chromosomal aberrations is used to determine the prognosis of neuroblastomas (NBs) and to aid treatment decisions. MYCN amplification (MNA) alone…”
Get full text

Altered methylation of imprinted genes in neuroblastoma: implications for prognostic refinement by Suman, Medha, Löfgren, Maja, Fransson, Susanne, Yousuf, Jewahri Idris, Svensson, Johanna, Djos, Anna, Martinsson, Tommy, Kogner, Per, Kling, Teresia, Carén, Helena

“…Neuroblastoma (NB) is a complex disease, and the current understanding of NB biology is limited. Deregulation in genomic imprinting is a common event in…”
Get full text

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo by Wickström, Malin, Dyberg, Cecilia, Shimokawa, Takashi, Milosevic, Jelena, Baryawno, Ninib, Fuskevåg, Ole M., Larsson, Rolf, Kogner, Per, Zaphiropoulos, Peter G., Johnsen, John I.

“…Hedgehog (HH) signaling is an important regulator of embryogenesis that has been associated with the development of several types of cancer. HH signaling is…”
Get full text

Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target by Baryawno, Ninib, Rahbar, Afsar, Wolmer-Solberg, Nina, Taher, Chato, Odeberg, Jenny, Darabi, Anna, Khan, Zahidul, Sveinbjörnsson, Baldur, FuskevÅg, O-M, Segerström, Lova, Nordenskjöld, Magnus, Siesjö, Peter, Kogner, Per, Johnsen, John Inge, Söderberg-Nauclér, Cecilia

“…Medulloblastomas are the most common malignant brain tumors in children. They express high levels of COX-2 and produce PGE2, which stimulates tumor cell…”
Get full text

Omega-3 fatty acids in cancer, the protectors of good and the killers of evil? by Gleissman, Helena, Johnsen, John Inge, Kogner, Per

“…Omega-3 fatty acids have been implicated in cancer prevention and treatment. Conventional chemotherapeutics are considered “double-edged swords”, as they kill…”
Get full text

TC-hunter: identification of the insertion site of a transgenic gene within the host genome by Börjesson, Vanja, Martinez-Monleon, Angela, Fransson, Susanne, Kogner, Per, Johnsen, John Inge, Milosevic, Jelena, López, Marcela Dávila

“…Transgenic animal models are crucial for the study of gene function and disease, and are widely utilized in basic biological research, agriculture and pharma…”
Get full text

Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma by Carlson, Lena-Maria, Rasmuson, Agnes, Idborg, Helena, Segerström, Lova, Jakobsson, Per-Johan, Sveinbjörnsson, Baldur, Kogner, Per

“…Tumor-associated inflammation is a driving force in several adult cancers and intake of low-dose aspirin has proven to reduce cancer incidence. Little is known…”
Get full text

11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma by Siaw, Joachim Tetteh, Javanmardi, Niloufar, Van den Eynden, Jimmy, Lind, Dan Emil, Fransson, Susanne, Martinez-Monleon, Angela, Djos, Anna, Sjöberg, Rose-Marie, Östensson, Malin, Carén, Helena, Trøen, Gunhild, Beiske, Klaus, Berbegall, Ana P., Noguera, Rosa, Lai, Wei-Yun, Kogner, Per, Palmer, Ruth H., Hallberg, Bengt, Martinsson, Tommy

“…High-risk neuroblastomas typically display an undifferentiated or poorly differentiated morphology. It is therefore vital to understand molecular mechanisms…”
Get full text