Search Results - "KOGAN, Scott"

PML-RARα: changing myeloid networks by Kogan, Scott C.

Get full text

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference by Premsrirut, Prem K., Dow, Lukas E., Kim, Sang Yong, Camiolo, Matthew, Malone, Colin D., Miething, Cornelius, Scuoppo, Claudio, Zuber, Johannes, Dickins, Ross A., Kogan, Scott C., Shroyer, Kenneth R., Sordella, Raffaella, Hannon, Gregory J., Lowe, Scott W.

“…RNA interference is a powerful tool for studying gene function, however, the reproducible generation of RNAi transgenic mice remains a significant limitation…”
Get full text

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity by Chien, Yuchen, Scuoppo, Claudio, Wang, Xiaowo, Fang, Xueping, Balgley, Brian, Bolden, Jessica E, Premsrirut, Prem, Luo, Weijun, Chicas, Agustin, Lee, Cheng S, Kogan, Scott C, Lowe, Scott W

“…Cellular senescence acts as a potent barrier to tumorigenesis and contributes to the anti-tumor activity of certain chemotherapeutic agents. Senescent cells…”
Get full text

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia by Zuber, Johannes, Shi, Junwei, Wang, Eric, Rappaport, Amy R., Herrmann, Harald, Sison, Edward A., Magoon, Daniel, Qi, Jun, Blatt, Katharina, Wunderlich, Mark, Taylor, Meredith J., Johns, Christopher, Chicas, Agustin, Mulloy, James C., Kogan, Scott C., Brown, Patrick, Valent, Peter, Bradner, James E., Lowe, Scott W., Vakoc, Christopher R.

“…Brd4 target in acute myeloid leukaemia In an RNAi screen targeting chromatin regulators, Vakoc and colleagues find that maintenance of acute myeloid leukaemia…”
Get full text

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia by Swaminathan, Srividya, Klemm, Lars, Park, Eugene, Papaemmanuil, Elli, Ford, Anthony, Kweon, Soo-Mi, Trageser, Daniel, Hasselfeld, Brian, Henke, Nadine, Mooster, Jana, Geng, Huimin, Schwarz, Klaus, Kogan, Scott C, Casellas, Rafael, Schatz, David G, Lieber, Michael R, Greaves, Mel F, Müschen, Markus

“…Secondary mutations can drive the transformation of pre-leukemic clones that carry ETV6 - RUNX1 translocations. Müschen and colleagues show that repeated…”
Get full text

Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice by Voisset, Edwige, Moravcsik, Eva, Stratford, Eva W., Jaye, Amie, Palgrave, Christopher J., Hills, Robert K., Salomoni, Paolo, Kogan, Scott C., Solomon, Ellen, Grimwade, David

“…A hallmark of acute promyelocytic leukemia (APL) is altered nuclear architecture, with disruption of promyelocytic leukemia (PML) nuclear bodies (NBs) mediated…”
Get full text

Crenolanib is a selective type I pan-FLT3 inhibitor by Smith, Catherine Choy, Lasater, Elisabeth A., Lin, Kimberly C., Wang, Qi, McCreery, Melissa Quino, Stewart, Whitney K., Damon, Lauren E., Perl, Alexander E., Jeschke, Grace R., Sugita, Mayumi, Carroll, Martin, Kogan, Scott C., Kuriyan, John, Shah, Neil P.

“…Tyrosine kinase inhibitors (TKIs) represent transformative therapies for several malignancies. Two critical features necessary for maximizing TKI tolerability…”
Get full text

CUL4A Induces Epithelial-Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression by YUNSHAN WAN, MINGXIN WEN, LABARGE, Mark A, LIANG YOU, KOGAN, Scott C, GRAY, Joe W, MAO, Jian-Hua, GUANGWEI WEI, YONGWON KWON, YANGYANG XU, YUEYONG LIU, PENGJU ZHANG, XIUQUAN HE, QIN WANG, YURONG HUANG, JEN, Kuang-Yu

“…The ubiquitin ligase CUL4A has been implicated in tumorigenesis, but its contributions to progression and metastasis have not been evaluated. Here, we show…”
Get full text

Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of ETV6::RUNX1 by Fitch, Briana A, Situ, Jamilla, Wiemels, Joseph L, Kogan, Scott C, Zhou, Mi

Get full text

Preventing Bleeding With Direct-Acting Oral Anticoagulants by Schwartz, Janice B., Kogan, Scott C., Fang, Margaret C.

Get full text

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal by Zhao, Zhen, Zuber, Johannes, Diaz-Flores, Ernesto, Lintault, Laura, Kogan, Scott C, Shannon, Kevin, Lowe, Scott W

“…The p53 tumor suppressor limits proliferation in response to cellular stress through several mechanisms. Here, we test whether the recently described ability…”
Get full text

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance by Zuber, Johannes, Rappaport, Amy R, Luo, Weijun, Wang, Eric, Chen, Chong, Vaseva, Angelina V, Shi, Junwei, Weissmueller, Susann, Fellmann, Christof, Fellman, Christof, Taylor, Meredith J, Weissenboeck, Martina, Graeber, Thomas G, Kogan, Scott C, Vakoc, Christopher R, Lowe, Scott W

“…Although human cancers have complex genotypes and are genomically unstable, they often remain dependent on the continued presence of single-driver mutations-a…”
Get full text

Preclinical efficacy of MEK inhibition in Nras-mutant AML by Burgess, Michael R., Hwang, Eugene, Firestone, Ari J., Huang, Tannie, Xu, Jin, Zuber, Johannes, Bohin, Natacha, Wen, Tiffany, Kogan, Scott C., Haigis, Kevin M., Sampath, Deepak, Lowe, Scott, Shannon, Kevin, Li, Qing

“…Oncogenic NRAS mutations are highly prevalent in acute myeloid leukemia (AML). Genetic analysis supports the hypothesis that NRAS mutations cooperate with…”
Get full text

Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children by Wiemels, Joseph L, Wang, Rong, Zhou, Mi, Hansen, Helen, Gallant, Rachel, Jung, Junghyun, Mancuso, Nicholas, De Smith, Adam J, Metayer, Catherine, Kogan, Scott C, Ma, Xiaomei

Get full text

The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression by Mas, Gloria, Man, Na, Nakata, Yuichiro, Martinez-Caja, Concepcion, Karl, Daniel, Beckedorff, Felipe, Tamiro, Francesco, Chen, Chuan, Duffort, Stephanie, Itonaga, Hidehiro, Mookhtiar, Adnan K, Kunkalla, Kranthi, Valencia, Alfredo M, Collings, Clayton K, Kadoch, Cigall, Vega, Francisco, Kogan, Scott C, Shiekhattar, Ramin, Morey, Lluis, Bilbao, Daniel, Nimer, Stephen D

“…During emergency hematopoiesis, hematopoietic stem cells (HSCs) rapidly proliferate to produce myeloid and lymphoid effector cells, a response that is critical…”
Get full text

Early-life tobacco exposure is causally implicated in aberrant RAG-mediated recombination in childhood acute lymphoblastic leukemia by Liu, Tanxin, Xu, Keren, Pardeshi, Anmol, Myint, Swe Swe, Kang, Alice Y., Morimoto, Libby M., Lieber, Michael R., Wiemels, Joseph L., Kogan, Scott C., Metayer, Catherine, de Smith, Adam J.

Get full text

Mouse models of human AML accurately predict chemotherapy response by Zuber, Johannes, Radtke, Ina, Pardee, Timothy S, Zhao, Zhen, Rappaport, Amy R, Luo, Weijun, McCurrach, Mila E, Yang, Miao-Miao, Dolan, M Eileen, Kogan, Scott C, Downing, James R, Lowe, Scott W

“…The genetic heterogeneity of cancer influences the trajectory of tumor progression and may underlie clinical variation in therapy response. To model such…”
Get full text

Curing APL: Differentiation or Destruction? by Kogan, Scott C.

“…In a recent issue of Nature Medicine, Nasr et al. show that the effectiveness of all- trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia…”
Get full text

In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system by Snijders, Antoine M, Zhou, Mi, Whitehead, Todd P, Fitch, Briana, Pandey, Priyatama, Hechmer, Aaron, Huang, Abel, Schick, Suzaynn F, de Smith, Adam J, Olshen, Adam B, Metayer, Catherine, Mao, Jian-Hua, Wiemels, Joseph L, Kogan, Scott C

“…Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Thirdhand smoke (THS) is the residual tobacco contamination that remains after the…”
Get more information

mTORC1 Promotes Survival through Translational Control of Mcl-1 by Mills, John R., Hippo, Yoshitaka, Robert, Francis, Chen, Samuel M. H., Malina, Abba, Lin, Chen-Ju, Trojahn, Ulrike, Wendel, Hans-Guido, Charest, Al, Bronson, Roderick T., Kogan, Scott C., Nadon, Robert, Housman, David E., Lowe, Scott W., Pelletier, Jerry

“…Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent occurrence in human cancers and a major promoter of chemotherapeutic…”
Get full text