Search Results - "KOGA, Takaki"

Factor VIIa inhibitors: Target hopping in the serine protease family using X-ray structure determination by Shiraishi, Takuya, Kadono, Shojiro, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Iikura, Hitoshi, Esaki, Tohru, Koga, Takaki, Hattori, Kunihiro, Watanabe, Yoshiaki, Sakamoto, Akihisa, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Esaki, Keiko, Ohta, Masateru, Sato, Haruhiko, Kozono, Toshiro

“…We succeeded in target hopping in the serine protease family using crystal structures of human FVIIa/TF in complex with peptide mimetic inhibitors. Selective…”
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Design and Synthesis of Peptidomimetic Factor VIIa Inhibitors by Shiraishi, Takuya, Kadono, Shojiro, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Iikura, Hitoshi, Esaki, Tohru, Koga, Takaki, Hattori, Kunihiro, Watanabe, Yoshiaki, Sakamoto, Akihisa, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Esaki, Keiko, Ohta, Masateru, Sato, Haruhiko, Kozono, Toshiro

“…Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is regarded as a promising target for developing new anticoagulant drugs. In previous…”
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Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Suzuki, Tsukasa, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. Structure-based designs…”
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Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Suzuki, Tsukasa, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. A novel peptide mimetic…”
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The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor, in rat models of venous and arterial thrombosis by Cho, J H, Yun, C H, Seo, H S, Koga, T, Dan, T, Koo, B A, Kim, H Y

“…The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor (Ki = 4.9 nM) was evaluated in rat models of venous thrombosis combined with a…”
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Investigating oppressiveness and spaciousness in relation to building, trees, sky and ground surface: A study in Tokyo by Asgarzadeh, Morteza, Koga, Takaaki, Hirate, Kotaroh, Farvid, Maryam, Lusk, Anne

“…•Oppressiveness is important because of the evolution of urban form through the history.•The physical properties of high-rise buildings in urban environment…”
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Crystal structure of human factor VIIa/tissue factor in complex with peptide mimetic inhibitor by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…The 3D structure of human factor VIIa/soluble tissue factor in complex with a peptide mimetic inhibitor, propylsulfonamide- d-Thr-Met- p-aminobenzamidine, is…”
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Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones by Yamaguchi, Masahisa, Kamei, Kenshi, Koga, Takaki, Akima, Michitaka, Kuroki, Toshio, Ohi, Nobuhiro

“…A number of 4-substituted 2-[omega-(1-imidazolyl)alkyl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane A2…”
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Characterization of a novel .ALPHA.1-adrenoceptor antagonist, SGB-1534, in contractile response of isolated canine arterial and venous smooth muscle to exogenous noradrenaline: Comparison with prazosin, phentolamine and yohimbine by KOGA, Takaki, SHIRAKI, Yasuyuki, SAKAI, Kazushige

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The inhibitory effects of CP-060S on ischemia- and reperfusion-induced arrhythmias in anesthetized rats by Koga, Takaki, Akima, Michitaka, Tamura, Kazuhiko, Suzuki, Yoshiyuki, Kato, Tatsuya, Nabata, Hiroyuki

“…The protective effects of CP-060S , a novel calcium overload inhibitor with calcium antagonism, on ischemia-reperfusion induced arrhythmia were evaluated in…”
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Antihypertensive effects of a novel orally active angiotensin converting enzyme (ACE) inhibitor altiopril calcium (MC-838) in several hypertensive rat models by Aono, Junichiro, Koga, Takaki, Yamazaki, Tamotsu, Shiraki, Yasuyuki, Nabata, Hiroyuki, Sakai, Kazushige

“…The antihypertensive effects of altiopril calcium (MC-838), a novel inhibitor of ACE, compared with captopril, were evaluated in conscious hypertensive rat…”
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Isolation and characterization of vascular smooth muscle inositol 1,4,5-trisphosphate receptor by Islam, M O, Yoshida, Y, Koga, T, Kojima, M, Kangawa, K, Imai, S

“…myo-Inositol 1,4,5-trisphosphate (InsP3) receptor of porcine aorta was purified to near homogeneity and its biochemical properties were compared with those of…”
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The protective effects of CP‐060S on ischaemia‐ and reperfusion‐induced arrhythmias in anaesthetized rats by Koga, Takaki, Fukazawa, Masanori, Suzuki, Yoshiyuki, Akima, Michitaka, Adachi, Yuichiro, Tamura, Kazuhiko, Kato, Tatsuya, Kuromaru, Osamu

“…CP‐060S is a novel sodium and calcium overload inhibitor, and is also characterized as a calcium channel blocker. As these activities have each been shown…”
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Stimulation of plasma membrane Ca2+ -pump ATPase of vascular smooth muscle by cGMP-dependent protein kinase: functional reconstitution with purified proteins by Yoshida, Y, Toyosato, A, Islam, M O, Koga, T, Fujita, S, Imai, S

“…A 240-kDa protein isolated from porcine aortic smooth muscle as a substrate for cGMP-dependent protein kinase (cGMP kinase) whose phosphorylation was in a…”
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In Vitro and In Vivo Studies of AT-1362, a Newly Synthesized and Orally Active Inhibitor of Thrombin by Cho, Jae-hyung, Seo, Hyoung-sik, Yun, Chi-ho, Koo, Bon-am, Yoshida, Shoshin, Koga, Takaki, Dan, Takashi, Kim, Hak-yeop

“…AT-1362 was found to be a potent, selective, and competitive inhibitor of thrombin, with a Ki value of 6.7 nM. In a rat model of venous thrombosis induced by…”
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Actions of CP-060S on veratridine-induced Ca2+ overload in cardiomyocytes and mechanical activities in vascular strips by TAMURA, K, SUZUKI, Y, KOGA, T, AKIMA, M, KATO, T, NABATA, H

“…CP-060S, (-)-(S)-2-[3,5-bis(1, 1-dimethylethyl)-4-hydroxyphenyl]-3-[3-[N-methyl-N-[2-(3, 4-methylenedioxyphenoxy)ethyl]amino]propyl]-1,3-thiazolidin- 4-one…”
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Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones by Yamaguchi, Masahisa, Kamei, Kenshi, Koga, Takaki, Akima, Michitaka, Maruyama, Akinori, Kuroki, Toshio, Ohi, Nobuhiro

“…A series of novel 4-(3-pyridyl)-1(2H)-phthalazinone derivatives which possess dual activities of thromboxane A2 (TXA2) synthetase inhibition and…”
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Purification and characterization of 240-kDa cGMP-dependent protein kinase substrate of vascular smooth muscle. Close resemblance to inositol 1,4,5-trisphosphate receptor by KOGA, T, YOSHIDA, Y, JI-QUN CAI, MD OMEDUL ISLAM, IMAI, S

“…The 240-kDa, cGMP-dependent protein kinase substrate protein obtained from porcine aortic smooth muscle, whose phosphorylation was closely associated with…”
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Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4 by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…The crystal structure of human factor VIIa/soluble tissue factor (FVIIa/sTF) in complex with a highly selective peptide‐mimetic FVIIa inhibitor which shows…”
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Actions of CP-060 S on veratridine-induced Ca 2+ overload in cardiomyocytes and mechanical activities in vascular strips by Tamura, Kazuhiko, Suzuki, Yoshiyuki, Koga, Takaki, Akima, Michitaka, Kato, Tatsuya, Nabata, Hiroyuki

“…CP-060 S, (−)-( S)-2-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-3-[3-[N-methyl- N-[2-(3,4-methylenedi-oxyphenoxy)methyl]amino]propyl]-1,3-thiazolidin-4…”
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