Search Results - "KOENEN, Michael"

The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel by Schweizer, Patrick A., MD, Schröter, Julian, BSc, Greiner, Sebastian, MD, Haas, Jan, PhD, Yampolsky, Pessah, PhD, Mereles, Derliz, MD, Buss, Sebastian J., MD, Seyler, Claudia, PhD, Bruehl, Claus, PhD, Draguhn, Andreas, MD, Koenen, Michael, PhD, Meder, Benjamin, MD, Katus, Hugo A., MD, Thomas, Dierk, MD

“…Abstract Background Inherited arrhythmias were originally considered isolated electrical defects. There is growing evidence that ion channel dysfunction also…”
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Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling by Yampolsky, Pessah, Koenen, Michael, Mosqueira, Matias, Geschwill, Pascal, Nauck, Sebastian, Witzenberger, Monika, Seyler, Claudia, Fink, Thomas, Kruska, Mathieu, Bruehl, Claus, Schwoerer, Alexander P., Ehmke, Heimo, Fink, Rainer H. A., Draguhn, Andreas, Thomas, Dierk, Katus, Hugo A., Schweizer, Patrick A.

“…HCN channels underlie the depolarizing funny current (I f ) that contributes importantly to cardiac pacemaking. I f is upregulated in failing and infarcted…”
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Improved Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pacemaker Cells Using Novel Differentiation Protocols by Darche, Fabrice F., Ullrich, Nina D., Huang, Ziqiang, Koenen, Michael, Rivinius, Rasmus, Frey, Norbert, Schweizer, Patrick A.

“…Current protocols for the differentiation of human-induced pluripotent stem cells (hiPSC) into cardiomyocytes only generate a small amount of cardiac pacemaker…”
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Tiotropium Respimat Inhaler and the Risk of Death in COPD by Wise, Robert A, Anzueto, Antonio, Cotton, Daniel, Dahl, Ronald, Devins, Theresa, Disse, Bernd, Dusser, Daniel, Joseph, Elizabeth, Kattenbeck, Sabine, Koenen-Bergmann, Michael, Pledger, Gordon, Calverley, Peter

“…This large trial involving patients with chronic obstructive pulmonary disease examined the relative safety of tiotropium inhalation delivered by two different…”
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Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells by Schweizer, Patrick A, Darche, Fabrice F, Ullrich, Nina D, Geschwill, Pascal, Greber, Boris, Rivinius, Rasmus, Seyler, Claudia, Müller-Decker, Karin, Draguhn, Andreas, Utikal, Jochen, Koenen, Michael, Katus, Hugo A, Thomas, Dierk

“…Human induced pluripotent stem cells (hiPSC) harbor the potential to differentiate into diverse cardiac cell types. Previous experimental efforts were…”
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Quantitative Efficacy and Fate of Mesenchymal Stromal Cells Targeted to Cardiac Sites by Radiofrequency Catheter Ablation by Malik, Rizwan, Darche, Fabrice F., Rivinius, Rasmus, Seckinger, Anja, Krause, Ulf, Koenen, Michael, Thomas, Dierk, Katus, Hugo A., Schweizer, Patrick A.

“…Engraftment and functional integration of stem cells or stem cell-derived cells within cardiac tissue is an important prerequisite for cell replacement therapy…”
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A Distinct Cardiomyopathy by Schweizer, Patrick A., MD, Koenen, Michael, PhD, Katus, Hugo A., MD, Thomas, Dierk, MD

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Genetic suppression of atrial fibrillation using a dominant-negative ether-a-go-go–related gene mutant by Soucek, Radim, MD, Thomas, Dierk, MD, Kelemen, Kamilla, MD, Bikou, Olympia, MD, Seyler, Claudia, PhD, Voss, Frederik, MD, Becker, Rüdiger, MD, Koenen, Michael, PhD, Katus, Hugo A., MD, Bauer, Alexander, MD

“…Background Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Gene therapy–dependent modulation of atrial electrophysiology may provide…”
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Novel mouse model reveals distinct activity-dependent and -independent contributions to synapse development by Pacifici, Pier Giorgio, Peter, Christoph, Yampolsky, Pessah, Koenen, Michael, McArdle, Joseph J, Witzemann, Veit

“…The balanced action of both pre- and postsynaptic organizers regulates the formation of neuromuscular junctions (NMJ). The precise mechanisms that control the…”
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Acetylcholine receptor channel subtype directs the innervation pattern of skeletal muscle by Koenen, Michael, Peter, Christoph, Villarroel, Alfredo, Witzemann, Veit, Sakmann, Bert

“…Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction, and structural and functional analysis has assigned distinct…”
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Decrease in the oral bioavailability of dabigatran etexilate after co‐medication with rifampicin by Härtter, Sebastian, Koenen‐Bergmann, Michael, Sharma, Ashish, Nehmiz, Gerhard, Lemke, Ute, Timmer, Wolfgang, Reilly, Paul A.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Dabigatran etexilate is an oral prodrug that is rapidly converted to dabigatran, a direct and reversible thrombin…”
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Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1 by Thomas, Dierk, Khalil, Markus, Alter, Markus, Schweizer, Patrick A, Karle, Christoph A, Wimmer, Anna-Britt, Licka, Manuela, Katus, Hugo A, Koenen, Michael, Ulmer, Herbert E, Zehelein, Jörg

“…Abstract Hereditary long QT syndrome (LQTS) is a cardiovascular disorder characterized by prolongation of the QT interval on the surface ECG and a high risk…”
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Skipping of Exon 1 in the KCNQ1 Gene Causes Jervell and Lange-Nielsen Syndrome by Zehelein, Joerg, Kathoefer, Sven, Khalil, Markus, Alter, Markus, Thomas, Dierk, Brockmeier, Konrad, Ulmer, Herbert E., Katus, Hugo A., Koenen, Michael

“…The Jervell and Lange-Nielsen syndrome (JLNS) is a rare autosomal recessive form of the long QT syndrome linked with a profound hearing loss caused by…”
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Regulation of fast inactivation of cloned mammalian Ik(A) channels by cysteine oxidation by RUPPERSBERG, J. P, STOCKER, M, PONGS, O, HEINEMANN, S. H, FRANK, R, KOENEN, M

“…Modulation of neuronal excitability by regulation of K+ channels potentially plays a part in short-term memory but has not yet been studied at the molecular…”
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Pharmacokinetic and Safety Evaluation of BILR 355, a Second-Generation Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy Volunteers by FENGLEI HUANG, KOENEN-BERGMANN, Michael, MACGREGOR, Thomas R, RING, Arne, HATTOX, Susan, ROBINSON, Patrick

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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BS-452757-4 ANTI-ARRHYTHMIC EFFECTS OF ANDROGEN DEPRIVATION THERAPIES IN A SCN5A LOSS-OF-FUNCTION MOUSE MODEL by Schweizer, Patrick A., Kruska, Mathieu, Fink, Thomas, Thomas, Dierk, Frey, Norbert, Koenen, Michael

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Location of a Threonine Residue in the $\alpha $-subunit M2 Transmembrane Segment that Determines the Ion Flow through the Acetylcholine Receptor Channel by Villarroel, Alfredo, Herlitze, Stefan, Koenen, Michael, Sakmann, Bert

“…By the combination of cDNA manipulation and functional analysis of normal and mutant acetylcholine receptor (AChR) channels of Torpedo expressed in Xenopus…”
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A Distinct Cardiomyopathy: HCN4Syndrome Comprising Myocardial Noncompaction, Bradycardia, Mitral Valve Defects, and Aortic Dilation by Schweizer, Patrick A, Koenen, Michael, Katus, Hugo A, Thomas, Dierk

“…Given the challenging analysis of mechanistic pathways leading to LVNC associated with previously identified mutations, this specific entity is expected to…”
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GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome by Semino, Francesca, Darche, Fabrice F., Bruehl, Claus, Koenen, Michael, Skladny, Heyko, Katus, Hugo A., Frey, Norbert, Draguhn, Andreas, Schweizer, Patrick A.

“…Loss-of-function variants of SCN5A , encoding the sodium channel alpha subunit Nav1.5 are associated with high phenotypic variability and multiple cardiac…”
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Response to the letter by Dr Chin and co‐workers by Härtter, Sebastian, Koenen‐Bergmann, Michael, Sharma, Ashish, Nehmiz, Gerhard, Lemke, Ute, Timmer, Wolfgang, Reilly, Paul A.

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