Search Results - "KOEHLER, Jeffrey"

Laboratory Diagnosis of Lassa Fever by Raabe, Vanessa, Koehler, Jeffrey

“…Lassa virus remains an important cause of illness in West Africa and among the travelers returning from this region with an acute febrile illness. The symptoms…”
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A DNA vaccine for Crimean-Congo hemorrhagic fever protects against disease and death in two lethal mouse models by Garrison, Aura R, Shoemaker, Charles J, Golden, Joseph W, Fitzpatrick, Collin J, Suschak, John J, Richards, Michelle J, Badger, Catherine V, Six, Carolyn M, Martin, Jacqueline D, Hannaman, Drew, Zivcec, Marko, Bergeron, Eric, Koehler, Jeffrey W, Schmaljohn, Connie S

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus capable of causing a severe hemorrhagic fever disease in humans. There are currently no…”
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A highly multiplexed broad pathogen detection assay for infectious disease diagnostics by Koehler, Jeffrey W, Douglas, Christina E, Minogue, Timothy D

“…Rapid pathogen identification during an acute febrile illness is a critical first step for providing appropriate clinical care and patient isolation. Primary…”
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Optimized microRNA purification from TRIzol-treated plasma by Duy, Janice, Koehler, Jeffrey W, Honko, Anna N, Minogue, Timothy D

“…MicroRNAs (miRNAs) represent new and potentially informative diagnostic targets for disease detection and prognosis. However, little work exists documenting…”
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Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure by Johnston, Sara C, Ricks, Keersten M, Jay, Alexandra, Raymond, Jo Lynne, Rossi, Franco, Zeng, Xiankun, Scruggs, Jennifer, Dyer, David, Frick, Ondraya, Koehler, Jeffrey W, Kuehnert, Paul A, Clements, Tamara L, Shoemaker, Charles J, Coyne, Susan R, Delp, Korey L, Moore, Joshua, Berrier, Kerry, Esham, Heather, Shamblin, Joshua, Sifford, Willie, Fiallos, Jimmy, Klosterman, Leslie, Stevens, Stephen, White, Lauren, Bowling, Philip, Garcia, Terrence, Jensen, Christopher, Ghering, Jeanean, Nyakiti, David, Bellanca, Stephanie, Kearney, Brian, Giles, Wendy, Alli, Nazira, Paz, Fabian, Akers, Kristen, Danner, Denise, Barth, James, Johnson, Joshua A, Durant, Matthew, Kim, Ruth, Hooper, Jay W, Smith, Jeffrey M, Kugelman, Jeffrey R, Beitzel, Brett F, Gibson, Kathleen M, Pitt, Margaret L M, Minogue, Timothy D, Nalca, Aysegul

“…Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that…”
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FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science by Sichtig, Heike, Minogue, Timothy, Yan, Yi, Stefan, Christopher, Hall, Adrienne, Tallon, Luke, Sadzewicz, Lisa, Nadendla, Suvarna, Klimke, William, Hatcher, Eneida, Shumway, Martin, Aldea, Dayanara Lebron, Allen, Jonathan, Koehler, Jeffrey, Slezak, Tom, Lovell, Stephen, Schoepp, Randal, Scherf, Uwe

“…FDA proactively invests in tools to support innovation of emerging technologies, such as infectious disease next generation sequencing (ID-NGS). Here, we…”
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Persistent Crimean-Congo hemorrhagic fever virus infection in the testes and within granulomas of non-human primates with latent tuberculosis by Smith, Darci R, Shoemaker, Charles J, Zeng, Xiankun, Garrison, Aura R, Golden, Joseph W, Schellhase, Christopher W, Pratt, William, Rossi, Franco, Fitzpatrick, Collin J, Shamblin, Joshua, Kimmel, Adrienne, Zelko, Justine, Flusin, Olivier, Koehler, Jeffrey W, Liu, Jun, Coffin, Kayla M, Ricks, Keersten M, Voorhees, Matt A, Schoepp, Randal J, Schmaljohn, Connie S

“…Crimean-Congo hemorrhagic fever (CCHF) is the most medically important tick-borne viral disease of humans and tuberculosis is the leading cause of death…”
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Knowledge, attitudes, and practices regarding malaria transmission and prevention in an indigenous Maijuna community: a qualitative study in the Peruvian Amazon by Hogan, Kathryn M, Gilmore, Michael, McCarron, Graziella P, Griffiths, Brian M, Koehler, Jeffrey W, García, Guillermo A, von Fricken, Michael E

“…Peru is a low-endemic transmission area for malaria, where the majority (84%) of incident malaria cases are localized to the department of Loreto, which is…”
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Next-Generation Sequencing for Biodefense: Biothreat Detection, Forensics, and the Clinic by Minogue, Timothy D, Koehler, Jeffrey W, Stefan, Christopher P, Conrad, Turner A

“…Next-generation sequencing (NGS) is revolutionizing a variety of molecular biology fields including bioforensics, biosurveillance, and infectious disease…”
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Exploring Crimean-Congo Hemorrhagic Fever Virus-Induced Hepatic Injury Using Antibody-Mediated Type I Interferon Blockade in Mice by Lindquist, Michael E, Zeng, Xiankun, Altamura, Louis A, Daye, Sharon P, Delp, Korey L, Blancett, Candace, Coffin, Kayla M, Koehler, Jeffrey W, Coyne, Susan, Shoemaker, Charles J, Garrison, Aura R, Golden, Joseph W

“…Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe hepatic injury in humans. However, the mechanism(s) causing this damage is poorly characterized…”
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Wide distribution of Mediterranean and African spotted fever agents and the first identification of Israeli spotted fever agent in ticks in Uganda by Eneku, Wilfred, Erima, Bernard, Byaruhanga, Anatoli Maranda, Atim, Gladys, Tugume, Titus, Ukuli, Qouilazoni A, Kibuuka, Hannah, Mworozi, Edison, Douglas, Christina, Koehler, Jeffrey W, Cleary, Nora G, von Fricken, Michael E, Tweyongyere, Robert, Wabwire-Mangen, Fred, Byarugaba, Denis Karuhize

“…Rickettsia microorganisms are causative agents of several neglected emerging infectious diseases in humans transmitted by arthropods including ticks. In this…”
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Evaluation of inhibitor-resistant real-time PCR methods for diagnostics in clinical and environmental samples by Trombley Hall, Adrienne, McKay Zovanyi, Ashley, Christensen, Deanna Rose, Koehler, Jeffrey William, Devins Minogue, Timothy

“…Polymerase chain reaction (PCR) is commonly used for pathogen detection in clinical and environmental samples. These sample matrices often contain inhibitors…”
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Targeted next-generation sequencing for the detection of ciprofloxacin resistance markers using molecular inversion probes by Stefan, Christopher P., Koehler, Jeffrey W., Minogue, Timothy D.

“…Antibiotic resistance (AR) is an epidemic of increasing magnitude requiring rapid identification and profiling for appropriate and timely therapeutic measures…”
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Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda-2016 by Kayiwa, John T, Mayanja, Martin N, Nakayiki, Teddy Muwawu, Senfuka, Fred, Mugga, Julius, Koehler, Jeffrey W, Mossel, Eric C, Lutwama, Julius J

“…After confirmation of two human cases of Rift Valley fever (RVF) in March 2016 in the Kabale district of Uganda, an entomological investigation was conducted…”
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Ticks and prevalence of tick-borne pathogens from domestic animals in Ghana by Nimo-Paintsil, Shirley C, Mosore, Mba, Addo, Seth Offei, Lura, Taylor, Tagoe, Janice, Ladzekpo, Danielle, Addae, Charlotte, Bentil, Ronald E, Behene, Eric, Dafeamekpor, Courage, Asoala, Victor, Fox, Anne, Watters, Chaselynn M, Koehler, Jeffrey W, Schoepp, Randy J, Arimoto, Hanayo, Dadzie, Samuel, Letizia, Andrew, Diclaro, 2nd, Joseph W

“…Ticks are important vectors of various pathogenic protozoa, bacteria and viruses that cause serious and life-threatening illnesses in humans and animals…”
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Sequence optimized diagnostic assay for Ebola virus detection by Koehler, Jeffrey W., Stefan, Christopher P., Hall, Adrienne T., Delp, Korey L., O’Hearn, Aileen E., Taylor-Howell, Cheryl L., Wauquier, Nadia, Schoepp, Randal J., Minogue, Timothy D.

“…Rapid pathogen identification is a critical first step in patient isolation, treatment, and controlling an outbreak. Real-time PCR is a highly sensitive and…”
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Crimean-Congo Hemorrhagic Fever Virus, Mongolia, 2013-2014 by Voorhees, Matthew A, Padilla, Susana L, Jamsransuren, Dulamjav, Koehler, Jeffrey W, Delp, Korey L, Adiyadorj, Dolgorkhand, Baasandagwa, Uyanga, Jigjav, Battsetseg, Olschner, Scott P, Minogue, Timothy D, Schoepp, Randal J

“…During 2013-2014, we collected 1,926 serum samples from humans and 4,583 ticks (Hyalomma asiaticum or Dermacentor nuttalli) in select regions of Mongolia to…”
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Development and evaluation of a panel of filovirus sequence capture probes for pathogen detection by next-generation sequencing by Koehler, Jeffrey W, Hall, Adrienne T, Rolfe, P Alexander, Honko, Anna N, Palacios, Gustavo F, Fair, Joseph N, Muyembe, Jean-Jacques, Mulembekani, Prime, Schoepp, Randal J, Adesokan, Adeyemi, Minogue, Timothy D

“…A detailed understanding of the circulating pathogens in a particular geographic location aids in effectively utilizing targeted, rapid diagnostic assays, thus…”
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Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19 by Zumbrun, Elizabeth E, Kaku, Chengzi I, Dillinger, Lukas, Zak, Samantha E, Kuehne, Ana I, Bakken, Russel R, Koehler, Jeffrey W, Delp, Korey L, Stefan, Christopher P, Kumar, Raina, Kugelman, Jeffrey R, Moreau, Alicia M, Zeng, Xiankun, Dye, John M, Herbert, Andrew S, Narayan, Kristin, Walker, Laura M

“…Adintrevimab is a human immunoglobulin G1 monoclonal antibody engineered to have broad neutralization against severe acute respiratory syndrome coronavirus 2…”
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Targeted Next-Generation Sequencing for Diagnostics and Forensics by Minogue, Timothy D, Koehler, Jeffrey W, Norwood, David A

“…[...]at higher clinically relevant concentrations of genomic input, nonamplified samples showed higher degrees of SNP coverage due to the wider representation…”
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