Search Results - "KOEDEL, Uwe"

The Glymphatic System: a Potential Key Player in Bacterial Meningitis by Oggioni, Marco Rinaldo, Koedel, Uwe

“…The glial-lymphatic system (glymphatic system) is a recently characterized fluid clearance pathway of the central nervous system. Glymphatic system…”
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The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release by Hoegen, Tobias, Tremel, Nadin, Klein, Matthias, Angele, Barbara, Wagner, Hermann, Kirschning, Carsten, Pfister, Hans-Walter, Fontana, Adriano, Hammerschmidt, Sven, Koedel, Uwe

“…Streptococcus pneumoniae meningitis causes brain damage through inflammation-related pathways whose identity and mechanisms of action are yet unclear. We…”
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Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis by Koedel, Uwe, Frankenberg, Tobias, Kirschnek, Susanne, Obermaier, Bianca, Häcker, Hans, Paul, Robert, Häcker, Georg

“…During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken…”
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SOP: emergency workup in patients with suspected acute bacterial meningitis by Dyckhoff-Shen, Susanne, Koedel, Uwe, Pfister, Hans-Walter, Klein, Matthias

“…Despite antibiotic therapy, adjunctive treatment with dexamethasone, and care on modern intensive care units, bacterial meningitis remains a life-threatening…”
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The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis by Rupprecht, Tobias A, Plate, Andreas, Adam, Michaela, Wick, Manfed, Kastenbauer, Stefan, Schmidt, Caroline, Klein, Matthias, Pfister, Hans-Walter, Koedel, Uwe

“…The chemokine CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue…”
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New understandings on the pathophysiology of bacterial meningitis by Koedel, Uwe, Klein, Matthias, Pfister, Hans-Walter

“…PURPOSE OF REVIEWCurrently, dexamethasone is the only adjuvant of proven benefit in bacterial meningitis. Dexamethasone halves the risk of poor outcome, but…”
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Mutual regulation of CD4 + T cells and intravascular fibrin in infections by Mueller, Tonina T, Pilartz, Mona, Thakur, Manovriti, LangHeinrich, Torben, Luo, Junfu, Block, Rebecca, Hoeflinger, Jonathan K L, Meister, Sarah, Karaj, Flavio, Perez, Laura Garcia, Öllinger, Rupert, Engleitner, Thomas, Thoss, Jakob, Voelkl, Michael, Tersteeg, Claudia, Koedel, Uwe, Kohlmaier, Alexander Zigman, Teupser, Daniel, Wygrecka, Malgorzata, Ye, Haifeng, Preissner, Klaus T, Radbruch, Helena, Elezkurtaj, Sefer, Mack, Matthias, Von Hundelshausen, Philipp, Weber, Christian, Massberg, Steffen, Schulz, Christian, Rad, Roland, Huber, Samuel, Ishikawa-Ankerhold, Hellen, Engelmann, Bernd

“…Innate myeloid cells especially neutrophils and their extracellular traps are known to promote intravascular coagulation and thrombosis formation in infections…”
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In vivo proteomics identifies the competence regulon and AliB oligopeptide transporter as pathogenic factors in pneumococcal meningitis by Schmidt, Frank, Kakar, Niamatullah, Meyer, Tanja C, Depke, Maren, Masouris, Ilias, Burchhardt, Gerhard, Gómez-Mejia, Alejandro, Dhople, Vishnu, Håvarstein, Leiv S, Sun, Zhi, Moritz, Robert L, Völker, Uwe, Koedel, Uwe, Hammerschmidt, Sven

“…Streptococcus pneumoniae (pneumococci) is a leading cause of severe bacterial meningitis in many countries worldwide. To characterize the repertoire of fitness…”
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Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood-brain barrier function by Teske, Nina C, Dyckhoff-Shen, Susanne, Beckenbauer, Paul, Bewersdorf, Jan Philipp, Engelen-Lee, Joo-Yeon, Hammerschmidt, Sven, Kälin, Roland E, Pfister, Hans-Walter, Brouwer, Matthijs C, Klein, Matthias, Glass, Rainer, van de Beek, Diederik, Koedel, Uwe

“…Brain pericytes participate in the regulation of cerebral blood flow and the maintenance of blood-brain barrier integrity. Because of their perivascular…”
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Patient disposition using the Emergency Severity Index: a retrospective observational study at an interdisciplinary emergency department by Völk, Stefanie, Koedel, Uwe, Horster, Sophia, Bayer, Andreas, D’Haese, Jan G, Pfister, Hans-Walter, Klein, Matthias

“…ObjectivesEarly patient disposition is crucial to prevent crowding in emergency departments (EDs). Our study aimed to characterise the need of in-house…”
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Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis by Masouris, Ilias, Klein, Matthias, Dyckhoff, Susanne, Angele, Barbara, Pfister, H W, Koedel, Uwe

“…Pneumococcal meningitis remains a potentially lethal and debilitating disease, mainly due to brain damage from sustained inflammation. The release of…”
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APRIL and BAFF: novel biomarkers for central nervous system lymphoma by Mulazzani, Matthias, Huber, Marion, Borchard, Sabine, Langer, Sigrid, Angele, Barbara, Schuh, Elisabeth, Meinl, Edgar, Dreyling, Martin, Birnbaum, Tobias, Straube, Andreas, Koedel, Uwe, von Baumgarten, Louisa

“…Early diagnosis of CNS lymphoma (CNSL) is essential for successful therapy of this rapidly progressing brain tumor. However, in patients presenting with focal…”
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CXCL13 and CXCL9 CSF Levels in Central Nervous System Lymphoma-Diagnostic, Therapeutic, and Prognostic Relevance by Masouris, Ilias, Manz, Kirsi, Pfirrmann, Markus, Dreyling, Martin, Angele, Barbara, Straube, Andreas, Langer, Sigrid, Huber, Marion, Koedel, Uwe, Von Baumgarten, Louisa

“…Diagnostic delay and neurologic deterioration are still a problem for the treatment of rapidly progressing CNS lymphoma (CNSL); there is an unmet need for a…”
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Myeloid-Related Protein 14 Promotes Inflammation and Injury in Meningitis by Wache, Christina, Klein, Matthias, Ostergaard, Christian, Angele, Barbara, Häcker, Hans, Pfister, Hans-Walter, Pruenster, Monika, Sperandio, Markus, Leanderson, Tomas, Roth, Johannes, Vogl, Thomas, Koedel, Uwe

“…Background. Neutrophilic inflammation often persists for days despite effective antibiotic treatment and contributes to brain damage in bacterial meningitis…”
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Innate Immunity to Pneumococcal Infection of the Central Nervous System Depends on Toll-Like Receptor (TLR) 2 and TLR4 by Klein, Matthias, Obermaier, Bianca, Angele, Barbara, Pfister, Hans-Walter, Wagner, Hermann, Koedel, Uwe, Kirschning, Carsten J.

“…Background. Recent studies have suggested that, in addition to Toll-like receptor (TLR) 2, other pattern recognition receptors mediate activation of the immune…”
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Pathogenesis and pathophysiology of pneumococcal meningitis by Koedel, Uwe, Scheld, William Michael, Pfister, Hans-Walter

“…Until the introduction of antibiotics in the 1930s and 1940s, acute bacterial meningitis was fatal in most cases. Since then it has become curable with a…”
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The role of host and microbial factors in the pathogenesis of pneumococcal bacteraemia arising from a single bacterial cell bottleneck by Gerlini, Alice, Colomba, Leonarda, Furi, Leonardo, Braccini, Tiziana, Manso, Ana Sousa, Pammolli, Andrea, Wang, Bo, Vivi, Antonio, Tassini, Maria, van Rooijen, Nico, Pozzi, Gianni, Ricci, Susanna, Andrew, Peter W, Koedel, Uwe, Moxon, E Richard, Oggioni, Marco R

“…The pathogenesis of bacteraemia after challenge with one million pneumococci of three isogenic variants was investigated. Sequential analyses of blood samples…”
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Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy by Ricci, Susanna, Grandgirard, Denis, Masouris, Ilias, Braccini, Tiziana, Pozzi, Gianni, Oggioni, Marco R, Koedel, Uwe, Leib, Stephen L

“…Meningococcal meningitis (MM) is a life-threatening disease associated with approximately 10% case fatality rates and neurological sequelae in 10-20% of the…”
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Impact of Glutamine Transporters on Pneumococcal Fitness under Infection-Related Conditions by Härtel, Tobias, Klein, Matthias, Koedel, Uwe, Rohde, Manfred, Petruschka, Lothar, Hammerschmidt, Sven

“…The genomic analysis of Streptococcus pneumoniae predicted six putative glutamine uptake systems, which are expressed under in vitro conditions, as shown here…”
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Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis by Klein, Matthias, Brouwer, Matthijs C, Angele, Barbara, Geldhoff, Madelijn, Marquez, Gabriel, Varona, Rosa, Häcker, Georg, Schmetzer, Helga, Häcker, Hans, Hammerschmidt, Sven, van der Ende, Arie, Pfister, Hans-Walter, van de Beek, Diederik, Koedel, Uwe

“…We previously identified CCL20 as an early chemokine in the cerebrospinal fluid (CSF) of patients with pneumococcal meningitis but its functional relevance was…”
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