Search Results - "KODE, Aruna"

Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method by Rahman, Irfan, Kode, Aruna, Biswas, Saibal K

“…The spectrophotometric/microplate reader assay method for glutathione (GSH) involves oxidation of GSH by the sulfhydryl reagent 5,5'-dithio-bis(2-nitrobenzoic…”
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Oxidant and antioxidant balance in the airways and airway diseases by Rahman, Irfan, Biswas, Saibal K, Kode, Aruna

“…Although oxygen is a prerequisite to life, at concentrations beyond the physiological limits it may be hazardous to the cells. Since the lungs are directly…”
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Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells by Kode, Aruna, Yang, Se-Ran, Rahman, Irfan

“…Cigarette smoke mediated oxidative stress and inflammatory events in the airway and alveolar epithelium are important processes in the pathogenesis of smoking…”
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Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells by Kode, Aruna, Rajendrasozhan, Saravanan, Caito, Samuel, Yang, Se-Ran, Megson, Ian L, Rahman, Irfan

“…Nuclear erythroid-related factor 2 (Nrf2), a redox-sensitive transcription factor, is involved in transcriptional regulation of many antioxidant genes,…”
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FoxO1 Is a Positive Regulator of Bone Formation by Favoring Protein Synthesis and Resistance to Oxidative Stress in Osteoblasts by Rached, Marie-Therese, Kode, Aruna, Xu, Lili, Yoshikawa, Yoshihiro, Paik, Ji-Hye, DePinho, Ronald A., Kousteni, Stavroula

“…Osteoporosis, a disease of low bone mass, is associated with decreased osteoblast numbers and increased levels of oxidative stress within osteoblasts. Since…”
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Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts by Krevvata, Maria, Silva, Barbara C., Manavalan, John S., Galan-Diez, Marta, Kode, Aruna, Matthews, Brya Grace, Park, David, Zhang, Chiyuan A., Galili, Naomi, Nickolas, Thomas L., Dempster, David W., Dougall, William, Teruya-Feldstein, Julie, Economides, Aris N., Kalajzic, Ivo, Raza, Azra, Berman, Ellin, Mukherjee, Siddhartha, Bhagat, Govind, Kousteni, Stavroula

“…The bone marrow niche is thought to act as a permissive microenvironment required for emergence or progression of hematologic cancers. We hypothesized that…”
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Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual by Kajimura, Daisuke, Hinoi, Eiichi, Ferron, Mathieu, Kode, Aruna, Riley, Kyle J, Zhou, Bin, Guo, X Edward, Karsenty, Gerard

“…The sympathetic nervous system, whose activity is regulated by leptin signaling in the brain, is a major regulator of bone mass accrual. To determine the…”
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Genetic evidence points to an osteocalcin‐independent influence of osteoblasts on energy metabolism by Yoshikawa, Yoshihiro, Kode, Aruna, Xu, Lili, Mosialou, Ioanna, Silva, Barbara C, Ferron, Mathieu, Clemens, Thomas L, Economides, Aris N, Kousteni, Stavroula

“…The skeleton has been shown recently to regulate glucose metabolism through an osteoblast‐specific hormone, osteocalcin, which favors β‐cell proliferation,…”
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FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin by Kode, Aruna, Mosialou, Ioanna, Silva, Barbara C, Rached, Marie-Therese, Zhou, Bin, Wang, Ji, Townes, Tim M, Hen, Rene, DePinho, Ronald A, Guo, X Edward, Kousteni, Stavroula

“…Serotonin is a critical regulator of bone mass, fulfilling different functions depending on its site of synthesis. Brain-derived serotonin promotes osteoblast…”
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Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice by Yao, Hongwei, Edirisinghe, Indika, Yang, Se-Ran, Rajendrasozhan, Saravanan, Kode, Aruna, Caito, Samuel, Adenuga, David, Rahman, Irfan

“…Cigarette smoke (CS) induces recruitment of inflammatory cells in the lungs leading to the generation of reactive oxygen species (ROS), which are involved in…”
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Azithromycin suppresses activation of nuclear factor-kappa b and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants by AGHAI, Zubair H, KODE, Aruna, SASLOW, Judy G, NAKHLA, Tarek, FARHATH, Sabeena, STAHL, Gary E, EYDELMAN, Riva, STRANDE, Louise, LEONE, Paola, RAHMAN, Irfan

“…Nuclear factor-kappaB (NF-kappaB) plays a central role in regulating key proinflammatory mediators. The activation of NF-kappaB is increased in tracheal…”
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Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema by Baglole, Carolyn J, Bushinsky, Seth M, Garcia, Tatiana M, Kode, Aruna, Rahman, Irfan, Sime, Patricia J, Phipps, Richard P

“…Cigarette smoke is the principal cause of emphysema. Recent attention has focused on the loss of alveolar fibroblasts in the development of emphysema…”
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Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells by Kode, Aruna, Yang, Se-Ran, Rahman, Irfan

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Hepatoprotective role of ferulic acid: a dose-dependent study by Rukkumani, Rajagopalan, Aruna, Kode, Suresh Varma, Penumathsa, Padmanabhan Menon, Venugopal

“…Alcohol use is contributing to an unprecedented decline in life expectancy. Damage to the liver after ethanol administration is a well-known phenomenon. Free…”
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Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts by Kode, Aruna, Manavalan, John S., Mosialou, Ioanna, Bhagat, Govind, Rathinam, Chozha V., Luo, Na, Khiabanian, Hossein, Lee, Albert, Murty, Vundavalli V., Friedman, Richard, Brum, Andrea, Park, David, Galili, Naomi, Mukherjee, Siddhartha, Teruya-Feldstein, Julie, Raza, Azra, Rabadan, Raul, Berman, Ellin, Kousteni, Stavroula

“…A mouse model shows that osteoblast activating β-catenin mutations alone are sufficient to initiate the development of acute myeloid leukaemia acting through…”
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FoxO1 Protein Cooperates with ATF4 Protein in Osteoblasts to Control Glucose Homeostasis by Kode, Aruna, Mosialou, Ioanna, Silva, Barbara C., Joshi, Sneha, Ferron, Mathieu, Rached, Marie Therese, Kousteni, Stavroula

“…The Forkhead transcription factor FoxO1 inhibits through its expression in osteoblasts β-cell proliferation, insulin secretion, and sensitivity. At least part…”
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FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice by Rached, Marie-Therese, Kode, Aruna, Silva, Barbara C, Jung, Dae Young, Gray, Susan, Ong, Helena, Paik, Ji-Hye, DePinho, Ronald A, Kim, Jason K, Karsenty, Gerard, Kousteni, Stavroula

“…Osteoblasts have recently been found to play a role in regulating glucose metabolism through secretion of osteocalcin. It is unknown, however, how this…”
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FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice by Kode, A, Mosialou, I, Manavalan, S J, Rathinam, C V, Friedman, R A, Teruya-Feldstein, J, Bhagat, G, Berman, E, Kousteni, S

“…Osteoblasts, the bone forming cells, affect self-renewal and expansion of hematopoietic stem cells (HSCs), as well as homing of healthy hematopoietic cells and…”
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Foxo1 Expressed in Osteoblasts Promotes the Leukemogenic Properties of β-Catenin By Activating Notch Signaling by Kode, Aruna, Mosialou, Ioanna, Manavalan, Sanil J, Feldstein, Julie Teruya, Bhagat, Govind, Berman, Ellin, Kousteni, Stavroula

“…Osteoblasts affect self-renewal and expansion of hematopoietic stem cells (HSCs) and homing of healthy hematopoietic and tumor cells into the bone marrow…”
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Targeting the Osteoblast in Myelodysplasia and Acute Myeloid Leukemia by Nakagawa, Masahiro Marshall, Kode, Aruna, Manavalan, Sanil J, Bhagat, Govind, Teruya-Feldstein, Julie, Raza, Azra, Berman, Ellin, Kousteni, Stavroula

“…It has previously been shown that an activating mutation in β-catenin in osteoblasts leads to the development of myelodysplasia (MDS) with rapid progression to…”
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