Search Results - "KOCISKO, D. A"

Prions and Transmissible Spongiform Encephalopathy (TSE) Chemotherapeutics:  A Common Mechanism for Anti-TSE Compounds? by Caughey, B, Caughey, W. S, Kocisko, D. A, Lee, K. S, Silveira, J. R, Morrey, J. D

“…No validated treatments exist for transmissible spongiform encephalopathies (TSEs or prion diseases) in humans or livestock. The search for TSE therapeutics is…”
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The efficacy and tolerability of three different regimens of tafenoquine versus primaquine for post-exposure prophylaxis of Plasmodium vivax malaria in the Southwest Pacific by Elmes, N.J., Nasveld, P.E., Kitchener, S.J., Kocisko, D.A., Edstein, M.D.

“…Tafenoquine is being developed for radical cure and post-exposure prophylaxis of Plasmodium vivax malaria. In an open-label study, 1512 Australian Defence…”
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Cell-free formation of protease-resistant prion protein by Kocisko, D.A, Come, J.H, Priola, S.A, Chesebro, B, Raymond, G.J, Lansbury, P.T, Caughey, B

“…The infectious agent (or 'prion') of the transmissible spongiform encephalopathies (TSEs) such as scrapie resembles a virus in that it replicates in vivo and…”
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Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies by Caughey, B, Raymond, G J, Kocisko, D A, Lansbury, Jr, P T

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Species Specificity in the Cell-Free Conversion of Prion Protein to Protease-Resistant Forms: A Model for the Scrapie Species Barrier by Kocisko, David A., Priola, Suzette A., Raymond, Gregory J., Chesebro, Bruce, Lansbury, Peter T., Caughey, Byron

“…Scrapie is a transmissible neurodegenerative disease that appears to result from an accumulation in the brain of an abnormal protease-resistant isoform of…”
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Molecular assessment of the potential transmissibilities of BSE and scrapie to humans by Caughey, Byron, Raymond, Gregory J, Hope, James, Kocisko, David A, Priola, Suzette A, Raymond, Lynne D, Bossers, Alex, Ironside, James, Will, Robert G, Chen, Shu G, Petersen, Robert B, Gambetti, Pierluigi, Rubenstein, Richard, Smits, Mari A, Lansbury, Peter T

“…More than a million cattle infected with bovine spongiform encephalopathy (BSE) may have entered the human food chain. Fears that BSE might transmit to man…”
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Gender differences in gastrointestinal disturbances and plasma concentrations of tafenoquine in healthy volunteers after tafenoquine administration for post-exposure vivax malaria prophylaxis by Edstein, M.D., Nasveld, P.E., Kocisko, D.A., Kitchener, S.J., Gatton, M.L., Rieckmann, K.H.

“…In an open-label sequential cohort study, we compared gastrointestinal (GI) disturbances and plasma tafenoquine concentrations after administration of…”
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Determination of Peptide Amide Configuration in a Model Amyloid Fibril by Solid-State NMR by Costa, P. R, Kocisko, D. A, Sun, B. Q, Lansbury, P. T, Griffin, R. G

“…The β-amyloid proteins (Aβ), especially the variant Aβ1−42, are the primary constituent of the amyloid plaques which are characteristic of Alzheimer's disease…”
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Non-genetic propagation of strain-specific properties of scrapie prion protein by Bessen, Richard A, Kocisko, David A, Raymond, Gregory J, Nandan, Santosh, Lansbury, Peter T, Caughey, Byron

“…The infectious agents causing scrapie and other transmissible spongiform encephalopathies have been postulated to consist solely of the protease-resistant form…”
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Measurement of tafenoquine (WR 238605) in human plasma and venous and capillary blood by high-pressure liquid chromatography by KOCISKO, D. A, WALSH, D. S, EAMSILA, C, EDSTEIN, M. D

“…A simple, rapid, and accurate high-pressure liquid chromatographic method with fluorescence detection is described for the measurement of tafenoquine (TQ)…”
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Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems : An update by CAUGHEY, B, RAYMOND, G. J, PRIOLA, S. A, KOCISKO, D. A, RACE, R. E, BESSEN, R. A, LANSBURY, P. T, CHESEBRO, B

“…Transmissible spongiform encephalopathies (TSE) or prion diseases result in aberrant metabolism of prion protein (PrP) and the accumulation of a…”
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Effects of Plasmodium berghei infection on cytochromes P-450 2E1 and 3A2 by UHL, K, GRACE, J. M, KOCISKO, D. A, JENNINGS, B. T, MITCHELL, A. L, BREWER, T. G

“…Metabolism and disposition of most drugs used to treat malaria are substantially altered in malaria infection. Few data are available that specify effects of…”
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Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide by Lansbury, Peter T, Costa, Philip R, Griffiths, Janet M, Simon, Eric J, Auger, Michèle, Halverson, Kurt J, Kocisko, David A, Hendsch, Zachary S, Ashburn, Ted T, Spencer, Richard G.S, Tidor, Bruce, Griffin, Robert G

“…Amyloids are a class of noncrystalline, yet ordered, protein aggregates. A new approach was used to provide the initial structural data on an amyloid…”
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Plasma Concentrations of Tafenoquine, a New Long-Acting Antimalarial Agent, in Thai Soldiers Receiving Monthly Prophylaxis by Edstein, Michael D., Kocisko, David A., Walsh, Douglas S., Eamsila, Chirapa, Charles, Bruce G., Rieckmann, Karl H.

“…We measured plasma tafenoquine concentrations in Thai soldiers given a monthly regimen of tafenoquine to determine whether these concentrations adequately…”
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Partial Unfolding and Refolding of Scrapie-Associated Prion Protein:  Evidence for a Critical 16-kDa C-Terminal Domain by Kocisko, David A, Lansbury, Peter T, Caughey, Byron

“…The conversion of the normal form of prion protein (PrPC) to a disease-specific form (PrPSc) is a central event in scrapie and other transmissible spongiform…”
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Population pharmacokinetics of the new antimalarial agent tafenoquine in Thai soldiers by Edstein, Michael D., Kocisko, David A., Brewer, Thomas G., Walsh, Douglas S., Eamsila, Chirapa, Charles, Bruce G.

“…Aims  To describe the population pharmacokinetics of tafenoquine in healthy volunteers after receiving tafenoquine for malaria prophylaxis. Methods  The…”
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New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products by Kocisko, David A., Baron, Gerald S., Rubenstein, Richard, Chen, Jiancao, Kuizon, Salomon, Caughey, Byron

“…Erratum ( vol. 78 , p. 3202 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state by Caughey, Byron, Kocisko, David A., Raymond, Gregory J., Lansbury, Peter T.

“…Introduction: Scrapie infection instigates the in vivo conversion of normal, protease-sensitive prion protein (PrPc) into a protease-resistant form (PrP Sc) by…”
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Potent Antiscrapie Activities of Degenerate Phosphorothioate Oligonucleotides by KOCISKO, David A, VAILLANT, Andrew, KIL SUN LEE, ARNOLD, Kevin M, BERTHOLET, Nadine, RACE, Richard E, OLSEN, Emily A, JUTEAU, Jean-Marc, CAUGHEY, Byron

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Mefloquine, an Antimalaria Drug with Antiprion Activity In Vitro, Lacks Activity In Vivo by KOCISKO, David A, CAUGHEY, Byron

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