Search Results - "KOCHI, Sims K"

Randomized, Controlled Human Challenge Study of the Safety, Immunogenicity, and Protective Efficacy of a Single Dose of Peru-15, a Live Attenuated Oral Cholera Vaccine by COHEN, Mitchell B, GIANNELLA, Ralph A, KILLEEN, Kevin P, BEAN, Judy, TAYLOR, David N, PARKER, Susan, HOEPER, Amy, WOWK, Stephen, HAWKINS, Jennifer, KOCHI, Sims K, SCHIFF, Gilbert

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Reactogenicity and immunogenicity of live attenuated Salmonella enterica serovar Paratyphi A enteric fever vaccine candidates by Roland, Kenneth L, Tinge, Steven A, Kochi, Sims K, Thomas, Lawrence J, Killeen, Kevin P

“…Abstract Eight Salmonella enterica serovar Paratyphi A strains were screened as candidates to create a live attenuated paratyphoid vaccine. Based on…”
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Construction and preclinical evaluation of recombinant Peru-15 expressing high levels of the cholera toxin B subunit as a vaccine against enterotoxigenic Escherichia coli by Roland, Kenneth L, Cloninger, Cheryl, Kochi, Sims K, Thomas, Lawrence J, Tinge, Steven A, Rouskey, Craig, Killeen, Kevin P

“…Abstract Enterotoxigenic Escherichia coli (ETEC) is the leading cause of traveler's diarrhea. The heat-labile (LT) and heat-stable (ST) toxins mediate ETEC…”
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Advances in the development of bacterial vector technology by Kochi, Sims K, Killeen, Kevin P, Ryan, Una S

“…The demand for new and improved vaccines against human diseases has continued unabated over the past century. While the need continues for traditional vaccines…”
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Development of a ΔglnA Balanced Lethal Plasmid System for Expression of Heterologous Antigens by Attenuated Vaccine Vector Strains of Vibrio cholerae by RYAN, E. T, CREAN, T. I, KOCHI, S. K, JOHN, M, LUCIANO, A. A, KILLEEN, K. P, KLOSE, K. E, CALDERWOOD, S. B

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The Effects of pH on the Interaction of Anthrax Toxin Lethal and Edema Factors with Phospholipid Vesicles by Kochi, Sims K, Martin, Isabelle, Schiavo, Giampietro, Mock, Michele, Cabiaux, Veronique

“…Bacillus anthracis secretes three distinct proteins which interact in binary combinations to produce two toxins. The two effector moieties, edema factor (EF)…”
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Recent advances in the development of live, attenuated bacterial vectors by Roland, Kenneth L, Tinge, Steven A, Killeen, Kevin P, Kochi, Sims K

“…Over the last quarter century, scientific advances have created new tools and technologies to improve the safety and efficacy of vaccines. These improvements…”
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Construction and preclinical evaluation of recombinant Peru-15 expressing high levels of the cholera toxin B subunit as a vaccine against enterotoxigenicEscherichia coli by Roland, Kenneth L, Cloninger, Cheryl, Kochi, Sims K, Thomas, Lawrence J, Tinge, Steven A, Rouskey, Craig, Killeen, Kevin P

“…EnterotoxigenicEscherichia coli(ETEC) is the leading cause of traveler's diarrhea. The heat-labile (LT) and heat-stable (ST) toxins mediate ETEC induced…”
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DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis by Kochi, S K, Collier, R J

“…We treated the human monoblastoid cell line, U937, with various cytotoxic proteins or drugs that specifically inhibit protein synthesis and monitored the cells…”
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Zinc content of the Bacillus anthracis lethal factor by Kochi, S K, Schiavo, G, Mock, M, Montecucco, C

“…We present evidence that the anthrax toxin lethal factor binds multiple zinc atoms. Results from atomic adsorption spectroscopy indicate that lethal factor…”
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Complement-mediated killing of the Lyme disease spirochete Borrelia burgdorferi. Role of antibody in formation of an effective membrane attack complex by Kochi, S.K. (Harvard University, Boston, MA), Johnson, R.C, Dalmasso, A.P

“…Lyme disease is a multisystemic illness caused by the spirochete Borrelia burgdorferi. In the absence of specific antibody, the spirochete is resistant to the…”
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