Search Results - "KOCHERGINSKY, Masha"

Transitions in Loneliness Among Older Adults: A 5-Year Follow-Up in the National Social Life, Health, and Aging Project by Hawkley, Louise C., Kocherginsky, Masha

“…A substantial portion of the older adult population suffers from frequent feelings of loneliness, but a large proportion remains relatively unscathed by…”
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Survival after Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer by Melamed, Alexander, Margul, Daniel J, Chen, Ling, Keating, Nancy L, del Carmen, Marcela G, Yang, Junhua, Seagle, Brandon-Luke L, Alexander, Amy, Barber, Emma L, Rice, Laurel W, Wright, Jason D, Kocherginsky, Masha, Shahabi, Shohreh, Rauh-Hain, J. Alejandro

“…An epidemiologic study that used large cancer databases (National Cancer Database and SEER) showed that minimally invasive hysterectomy was associated with…”
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The Use and Interpretation of Competing Risks Regression Models by DIGNAM, James J, QIANG ZHANG, KOCHERGINSKY, Masha

“…Competing risks observations, in which patients are subject to a number of potential failure events, are a feature of most clinical cancer studies. With…”
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Concordance study of PD-L1 expression in primary and metastatic bladder carcinomas: comparison of four commonly used antibodies and RNA expression by Tretiakova, Maria, Fulton, Regan, Kocherginsky, Masha, Long, Thomas, Ussakli, Cigdem, Antic, Tatjana, Gown, Allen

“…Therapy with anti-PD-L1 immune check-point inhibitors is approved for several cancers, including advanced urothelial carcinomas. PD-L1 prevalence estimates…”
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Optimal blood pressure during cardiopulmonary bypass defined by cerebral autoregulation monitoring by Hori, Daijiro, Nomura, Yohei, Ono, Masahiro, Joshi, Brijen, Mandal, Kaushik, Cameron, Duke, Kocherginsky, Masha, Hogue, Charles W.

“…We sought to define the lower and upper limits of cerebral blood flow autoregulation and the optimal blood pressure during cardiopulmonary bypass. We further…”
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Restricted mean survival time: Does covariate adjustment improve precision in randomized clinical trials? by Karrison, Theodore, Kocherginsky, Masha

“…Background: Restricted mean survival time is a measure of average survival time up to a specified time point. There has been an increased interest in using…”
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The Relationship Between Physical Activity and Frailty Among U.S. Older Adults Based on Hourly Accelerometry Data by Huisingh-Scheetz, Megan, Wroblewski, Kristen, Kocherginsky, Masha, Huang, Elbert, Dale, William, Waite, Linda, Schumm, L Philip

“…Accelerometry measures older adult (in)activity with high resolution. Most studies summarize activity over the entire wear time. We extend prior work by…”
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Identification of the toxic 6mer seed consensus for human cancer cells by Patel, Monal, Bartom, Elizabeth T., Paudel, Bidur, Kocherginsky, Masha, O’Shea, Kaitlyn L., Murmann, Andrea E., Peter, Marcus E.

“…6mer seed toxicity is a novel cell death mechanism that kills cancer cells by triggering death induced by survival gene elimination (DISE). It is based on si-…”
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Glucocorticoid Receptor Antagonism as a Novel Therapy for Triple-Negative Breast Cancer by SKOR, Maxwell N, WONDER, Erin L, KOCHERGINSKY, Masha, GOYAL, Anju, HALL, Ben A, YI CAI, CONZEN, Suzanne D

“…Triple-negative breast cancer (TNBC) accounts for 10% to 20% of newly diagnosed invasive breast cancer. Finding effective targets for chemotherapy-resistant…”
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Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer by West, Diana C, Kocherginsky, Masha, Tonsing-Carter, Eva Y, Dolcen, D Nesli, Hosfield, David J, Lastra, Ricardo R, Sinnwell, Jason P, Thompson, Kevin J, Bowie, Kathleen R, Harkless, Ryan V, Skor, Maxwell N, Pierce, Charles F, Styke, Sarah C, Kim, Caroline R, de Wet, Larischa, Greene, Geoffrey L, Boughey, Judy C, Goetz, Matthew P, Kalari, Krishna R, Wang, Liewei, Fleming, Gini F, Györffy, Balázs, Conzen, Suzanne D

“…Although high glucocorticoid receptor (GR) expression in early-stage estrogen receptor (ER)-negative breast cancer is associated with shortened relapse-free…”
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Epigenetic priming enhances antitumor immunity in platinum-resistant ovarian cancer by Chen, Siqi, Xie, Ping, Cowan, Matthew, Huang, Hao, Cardenas, Horacio, Keathley, Russell, Tanner, Edward J, Fleming, Gini F, Moroney, John W, Pant, Alok, Akasha, Azza M, Davuluri, Ramana V, Kocherginsky, Masha, Zhang, Bin, Matei, Daniela

“…BackgroundImmune checkpoint inhibitors (ICIs) have modest activity in ovarian cancer (OC). To augment their activity, we used priming with the hypomethylating…”
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Measuring Physical Activity with Hip Accelerometry among U.S. Older Adults: How Many Days Are Enough? by Kocherginsky, Masha, Huisingh-Scheetz, Megan, Dale, William, Lauderdale, Diane S, Waite, Linda

“…Accelerometers are increasingly used in research. Four to 7 days of monitoring is preferred to estimate average activity but may be burdensome for older…”
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Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients by Muffly, Lori S, Kocherginsky, Masha, Stock, Wendy, Chu, Quynh, Bishop, Michael R, Godley, Lucy A, Kline, Justin, Liu, Hongtao, Odenike, Olatoyosi M, Larson, Richard A, van Besien, Koen, Artz, Andrew S

“…Allogeneic hematopoietic cell transplantation is increasingly utilized in older adults. This study prospectively evaluated the prognostic utility of geriatric…”
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The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma by Ladomersky, Erik, Scholtens, Denise M, Kocherginsky, Masha, Hibler, Elizabeth A, Bartom, Elizabeth T, Otto-Meyer, Sebastian, Zhai, Lijie, Lauing, Kristen L, Choi, Jaehyuk, Sosman, Jeffrey A, Wu, Jennifer D, Zhang, Bin, Lukas, Rimas V, Wainwright, Derek A

“…Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and is associated with a median overall survival (mOS) of 16-21 months. Our previous…”
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Therapy-related B-cell acute lymphoblastic leukemia in adults has unique genetic profile with frequent loss of TP53 and inferior outcome by Barnea Slonim, Liron, Gao, Juehua, Burkart, Madelyn, Odetola, Oluwatobi E., Kocherginsky, Masha, Dinner, Shira N., Lu, Xinyan, Wehbe, Firas, Jennings, Lawrence, Altman, Jessica K., Mirza, Kamran M., Chen, Yi-Hua, Sukhanova, Madina

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Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma by Stringer-Reasor, Erica M, Baker, Gabrielle M, Skor, Maxwell N, Kocherginsky, Masha, Lengyel, Ernst, Fleming, Gini F, Conzen, Suzanne D

“…Abstract Objectives To test the hypothesis that glucocorticoid receptor (GR) activation increases resistance to chemotherapy in high-grade serous ovarian…”
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Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms by Saleiro, Diana, Wen, Jeremy Q., Kosciuczuk, Ewa M., Eckerdt, Frank, Beauchamp, Elspeth M., Oku, Chidera V., Blyth, Gavin T., Fischietti, Mariafausta, Ilut, Liliana, Colamonici, Marco, Palivos, William, Atsaves, Paula A., Tan, Dean, Kocherginsky, Masha, Weinberg, Rona Singer, Fish, Eleanor N., Crispino, John D., Hoffman, Ronald, Platanias, Leonidas C.

“…Interferons (IFNs) are key initiators and effectors of the immune response against malignant cells and also directly inhibit tumor growth. IFNα is highly…”
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Final Results of a Randomized Phase 2 Trial Investigating the Addition of Cetuximab to Induction Chemotherapy and Accelerated or Hyperfractionated Chemoradiation for Locoregionally Advanced Head and Neck Cancer by Seiwert, Tanguy Y., MD, Melotek, James M., MD, Blair, Elizabeth A., MD, Stenson, Kerstin M., MD, Salama, Joseph K., MD, Witt, Mary Ellyn, MS, RN, Brisson, Ryan J., BS, Chawla, Apoorva, MD, Dekker, Allison, RN, Lingen, Mark W., DDS, PhD, Kocherginsky, Masha, PhD, Villaflor, Victoria M., MD, Cohen, Ezra E.W., MD, Haraf, Daniel J., MD, Vokes, Everett E., MD

“…Purpose The role of cetuximab in the treatment of locoregionally advanced head and neck squamous cell cancer (LA-HNSCC) remains poorly defined. In this phase 2…”
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Association of Metformin Use with Outcomes in Advanced Endometrial Cancer Treated with Chemotherapy by Ezewuiro, Obiageli, Grushko, Tatyana A, Kocherginsky, Masha, Habis, Mohammed, Hurteau, Jean A, Mills, Kathryn A, Hunn, Jessica, Olopade, Olufunmilayo I, Fleming, Gini F, Romero, Iris L

“…There is increasing evidence that metformin, a commonly used treatment for diabetes, might have the potential to be repurposed as an economical and safe cancer…”
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SPOROS: A pipeline to analyze DISE/6mer seed toxicity by Bartom, Elizabeth T, Kocherginsky, Masha, Paudel, Bidur, Vaidyanathan, Aparajitha, Haluck-Kangas, Ashley, Patel, Monal, O'Shea, Kaitlyn L, Murmann, Andrea E, Peter, Marcus E

“…microRNAs (miRNAs) are (18-22nt long) noncoding short (s)RNAs that suppress gene expression by targeting the 3' untranslated region of target mRNAs. This…”
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