Search Results - "KOCH, WAYNE"

Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+ Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311) by Ferris, Robert L, Flamand, Yael, Weinstein, Gregory S, Li, Shuli, Quon, Harry, Mehra, Ranee, Garcia, Joaquin J, Chung, Christine H, Gillison, Maura L, Duvvuri, Umamaheswar, O'Malley, Jr, Bert W, Ozer, Enver, Thomas, Giovana R, Koch, Wayne M, Gross, Neil D, Bell, R Bryan, Saba, Nabil F, Lango, Miriam, Méndez, Eduardo, Burtness, Barbara

“…Definitive or postoperative chemoradiation (CRT) is curative for human papillomavirus-associated (HPV+) oropharynx cancer (OPC) but induces significant…”
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Novel Oral Cancer Survival Calculator-Do We Have a Crystal Ball? by Mady, Leila J, Koch, Wayne M, Fakhry, Carole

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Case–Control Study of Human Papillomavirus and Oropharyngeal Cancer by D'Souza, Gypsyamber, Kreimer, Aimee R, Viscidi, Raphael, Pawlita, Michael, Fakhry, Carole, Koch, Wayne M, Westra, William H, Gillison, Maura L

“…This study offers persuasive evidence of a strong association between exposure to or oral infection with the human papillomavirus and oropharyngeal cancer. The…”
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HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers by Ren, Shuling, Gaykalova, Daria A., Guo, Theresa, Favorov, Alexander V., Fertig, Elana J., Tamayo, Pablo, Callejas-Valera, Juan Luis, Allevato, Mike, Gilardi, Mara, Santos, Jessica, Fukusumi, Takahito, Sakai, Akihiro, Ando, Mizuo, Sadat, Sayed, Liu, Chao, Xu, Guorong, Fisch, Kathleen M., Wang, Zhiyong, Molinolo, Alfredo A., Gutkind, J. Silvio, Ideker, Trey, Koch, Wayne M., Califano, Joseph A.

“…The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative…”
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Saliva and plasma quantitative polymerase chain reaction-based detection and surveillance of human papillomavirus-related head and neck cancer by Ahn, Sun M, Chan, Jason Y K, Zhang, Zhe, Wang, Hao, Khan, Zubair, Bishop, Justin A, Westra, William, Koch, Wayne M, Califano, Joseph A

“…Human papillomavirus type 16 (HPV-16) is a major causative factor in oropharyngeal squamous cell carcinoma (OPSCC). The detection of primary OPSCC is often…”
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The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer by Fakhry, Carole, Westra, William H., Wang, Steven J., van Zante, Annemieke, Zhang, Yuehan, Rettig, Eleni, Yin, Linda X., Ryan, William R., Ha, Patrick K., Wentz, Alicia, Koch, Wayne, Richmon, Jeremy D., Eisele, David W., D'Souza, Gypsyamber

“…BACKGROUND Human papillomavirus (HPV) is a well‐established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of…”
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Assessment of the Predictive Value of the Modified Frailty Index for Clavien-Dindo Grade IV Critical Care Complications in Major Head and Neck Cancer Operations by Abt, Nicholas B, Richmon, Jeremy D, Koch, Wayne M, Eisele, David W, Agrawal, Nishant

“…Functional status and physiologic deficits independent of age are being recognized for surgical risk stratification. Frailty is expressed as a combination of…”
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Increasing prevalence of human papillomavirus–positive oropharyngeal cancers among older adults by Windon, Melina J., D'Souza, Gypsyamber, Rettig, Eleni M., Westra, William H., van Zante, Annemieke, Wang, Steven J., Ryan, William R., Mydlarz, Wojciech K., Ha, Patrick K., Miles, Brett A., Koch, Wayne, Gourin, Christine, Eisele, David W., Fakhry, Carole

“…BACKGROUND The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing among older adults. It is unknown whether these trends can be explained…”
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Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas by Wang, Yuxuan, Springer, Simeon, Mulvey, Carolyn L, Silliman, Natalie, Schaefer, Joy, Sausen, Mark, James, Nathan, Rettig, Eleni M, Guo, Theresa, Pickering, Curtis R, Bishop, Justin A, Chung, Christine H, Califano, Joseph A, Eisele, David W, Fakhry, Carole, Gourin, Christine G, Ha, Patrick K, Kang, Hyunseok, Kiess, Ana, Koch, Wayne M, Myers, Jeffrey N, Quon, Harry, Richmon, Jeremy D, Sidransky, David, Tufano, Ralph P, Westra, William H, Bettegowda, Chetan, Diaz, Jr, Luis A, Papadopoulos, Nickolas, Kinzler, Kenneth W, Vogelstein, Bert, Agrawal, Nishant

“…To explore the potential of tumor-specific DNA as a biomarker for head and neck squamous cell carcinomas (HNSCC), we queried DNA from saliva or plasma of 93…”
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Priorities, concerns, and regret among patients with head and neck cancer by Windon, Melina J., D’Souza, Gypsyamber, Faraji, Farhoud, Troy, Tanya, Koch, Wayne M., Gourin, Christine G., Kiess, Ana P., Pitman, Karen T., Eisele, David W., Fakhry, Carole

“…Background In the era of deintensification, little data are available regarding patients’ treatment preferences. The current study evaluated treatment‐related…”
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Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 by Agrawal, Nishant, Frederick, Mitchell J., Pickering, Curtis R., Bettegowda, Chetan, Chang, Kyle, Li, Ryan J., Fakhry, Carole, Xie, Tong-Xin, Zhang, Jiexin, Wang, Jing, Zhang, Nianxiang, El-Naggar, Adel K., Jasser, Samar A., Weinstein, John N., Treviño, Lisa, Drummond, Jennifer A., Muzny, Donna M., Wu, Yuanqing, Wood, Laura D., Hruban, Ralph H., Westra, William H., Koch, Wayne M., Califano, Joseph A., Gibbs, Richard A., Sidransky, David, Vogelstein, Bert, Velculescu, Victor E., Papadopoulos, Nickolas, Wheeler, David A., Kinzler, Kenneth W., Myers, Jeffrey N.

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To explore the genetic origins of this cancer, we used whole-exome…”
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Human Papillomavirus–related Carcinoma With Adenoid Cystic–like Features: A Peculiar Variant of Head and Neck Cancer Restricted to the Sinonasal Tract by Bishop, Justin A, Ogawa, Takenori, Stelow, Edward B, Moskaluk, Christopher A, Koch, Wayne M, Pai, Sara I, Westra, William H

“…Human papillomavirus (HPV)-related carcinomas of the head and neck are characterized by a predilection for the oropharynx, a nonkeratinizing squamous…”
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Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method by Bishop, Justin A, Ma, Xiao-Jun, Wang, Hongwei, Luo, Yuling, Illei, Peter B, Begum, Shanaz, Taube, Janis M, Koch, Wayne M, Westra, William H

“…Evidence for transcriptional activation of the viral oncoproteins E6 and E7 is regarded as the gold standard for the presence of clinically relevant human…”
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Novel insight into mutational landscape of head and neck squamous cell carcinoma by Gaykalova, Daria A, Mambo, Elizabeth, Choudhary, Ashish, Houghton, Jeffery, Buddavarapu, Kalyan, Sanford, Tiffany, Darden, Will, Adai, Alex, Hadd, Andrew, Latham, Gary, Danilova, Ludmila V, Bishop, Justin, Li, Ryan J, Westra, William H, Hennessey, Patrick, Koch, Wayne M, Ochs, Michael F, Califano, Joseph A, Sun, Wenyue

“…Development of head and neck squamous cell carcinoma (HNSCC) is characterized by accumulation of mutations in several oncogenes and tumor suppressor genes. We…”
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Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function by Serafini, Paolo, Meckel, Kristen, Kelso, Michael, Noonan, Kimberly, Califano, Joseph, Koch, Wayne, Dolcetti, Luigi, Bronte, Vincenzo, Borrello, Ivan

“…Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents currently in clinical use for nonmalignant conditions. We report the…”
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Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma by Califano, Joseph A, Khan, Zubair, Noonan, Kimberly A, Rudraraju, Lakshmi, Zhang, Zhe, Wang, Hao, Goodman, Steven, Gourin, Christine G, Ha, Patrick K, Fakhry, Carole, Saunders, John, Levine, Marshall, Tang, Mei, Neuner, Geoffrey, Richmon, Jeremy D, Blanco, Ray, Agrawal, Nishant, Koch, Wayne M, Marur, Shanthi, Weed, Donald T, Serafini, Paolo, Borrello, Ivan

“…To determine if phosphodiesterase 5 (PDE5) inhibitors can augment immune function in patients with head and neck cancer through inhibition of myeloid-derived…”
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TP53 Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck by Poeta, M. Luana, Manola, Judith, Goldwasser, Meredith A, Forastiere, Arlene, Benoit, Nicole, Califano, Joseph A, Ridge, John A, Goodwin, Jarrard, Kenady, Daniel, Saunders, John, Westra, William, Sidransky, David, Koch, Wayne M

“…TP53, the gene for the tumor-suppressor protein p53, is the most commonly mutated gene in cancer cells. In this study of head and neck cancer, about half the…”
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Utility of preoperative fine needle aspiration in parotid lesions by Eytan, Danielle F., Yin, Linda X., Maleki, Zahra, Koch, Wayne M., Tufano, Ralph P., Eisele, David W., Boahene, Kofi D. O., Fakhry, Carole, Bishop, Justin A., Westra, William H., Gourin, Christine G.

“…Objectives Preoperative fine needle aspiration (FNA) of parotid lesions often is used in the initial evaluation of parotid masses, but its role in guiding…”
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Characterization of functionally active gene fusions in human papillomavirus related oropharyngeal squamous cell carcinoma by Guo, Theresa, Gaykalova, Daria A., Considine, Michael, Wheelan, Sarah, Pallavajjala, Aparna, Bishop, Justin A, Westra, William H., Ideker, Trey, Koch, Wayne M, Khan, Zubair, Fertig, Elana J., Califano, Joseph A.

“…The Cancer Genome Atlas (TCGA) sequencing analysis of head and neck squamous cell carcinoma (HNSCC) recently reported on gene fusions, however, few human…”
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Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p53 Gene Mutations in Squamous Cell Carcinoma of the Head and Neck by WESTRA, William H, TAUBE, Janis M, POETA, M. L, BEGUM, Shanaz, SIDRANSKY, David, KOCH, Wayne M

“…Purpose: Squamous cell carcinomas of the head and neck (HNSCC) often harbor p53 mutations, but p53 protein degradation by the viral oncoprotein E6 may…”
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