Search Results - "KOCH, Birgit C. P"

Alternative Sampling Devices to Collect Dried Blood Microsamples: State-of-the-Art by Delahaye, Lisa, Veenhof, Herman, Koch, Birgit C. P., Alffenaar, Jan-Willem C., Linden, Rafael, Stove, Christophe

“…Dried blood spots (DBS) have been used in newborn screening programs for several years. More recently, there has been growing interest in using DBS as a home…”
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Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT) by Abdulla, Alan, Dijkstra, Annemieke, Hunfeld, Nicole G. M, Endeman, Henrik, Bahmany, Soma, Ewoldt, Tim M. J, Muller, Anouk E, van Gelder, Teun, Gommers, Diederik, Koch, Birgit C. P

“…Abstract Background Early and appropriate antibiotic dosing is associated with improved clinical outcomes in critically ill patients, yet target attainment…”
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Barriers and facilitators for therapeutic drug monitoring of beta-lactams and ciprofloxacin in the ICU: a nationwide cross-sectional study by Ewoldt, Tim M. J, Abdulla, Alan, van den Broek, Puck, Hunfeld, Nicole, Bahmany, Soma, Muller, Anouk E, Gommers, Diederik, Polinder, Suzanne, Endeman, Henrik, Spronk, Inge, Koch, Birgit C. P

“…Abstract Background Recent studies demonstrated that failure of achieving pharmacodynamic targets of commonly used antibiotics is common in critically ill…”
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The effect of therapeutic drug monitoring of risperidone and aripiprazole on weight gain in children and adolescents: the SPACe 2: STAR (trial) protocol of an international multicentre randomised controlled trial by Hermans, Rebecca A, Ringeling, Lisa T, Liang, Kajie, Kloosterboer, Sanne M, de Winter, Brenda C M, Hillegers, Manon H J, Koch, Birgit C P, Dierckx, Bram

“…Antipsychotic drugs are an important part of the treatment of irritability and aggression in children with an autism spectrum disorder (ASD). However,…”
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Clinical Experience with Off-Label Intrathecal Administration of Selected Antibiotics in Adults: An Overview with Pharmacometric Considerations by Muller, Anouk E, van Vliet, Peter, Koch, Birgit C. P

“…Drain-associated intracerebral infections are life-threatening emergencies. Their treatment is challenging due to the limited penetration of antibiotics to the…”
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Improving the tolerability of osimertinib by identifying its toxic limit by Agema, Bram C., Veerman, G. D. Marijn, Steendam, Christi M. J., Lanser, Daan A. C., Preijers, Tim, van der Leest, Cor, Koch, Birgit C. P., Dingemans, Anne-Marie C., Mathijssen, Ron H. J., Koolen, Stijn L. W.

“…Background: Osimertinib is the cornerstone in the treatment of epidermal growth factor receptor-mutated non-small cell lung cancer (NSCLC). Nonetheless, ±25%…”
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Exploring the Impact of Model-Informed Precision Dosing on Procalcitonin Concentrations in Critically Ill Patients: A Secondary Analysis of the DOLPHIN Trial by Dräger, Sarah, Ewoldt, Tim M J, Abdulla, Alan, Rietdijk, Wim J R, Verkaik, Nelianne, Ramakers, Christian, de Jong, Evelien, Osthoff, Michael, Koch, Birgit C P, Endeman, Henrik

“…Model-informed precision dosing (MIPD) might be used to optimize antibiotic treatment. Procalcitonin (PCT) is a biomarker for severity of infection and…”
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Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept by Mooij, Miriam G., van Duijn, Esther, Knibbe, Catherijne A. J., Windhorst, Albert D., Hendrikse, N. Harry, Vaes, Wouter H. J., Spaans, Edwin, Fabriek, Babs O., Sandman, Hugo, Grossouw, Dimitri, Hanff, Lidwien M., Janssen, Paul J. J. M., Koch, Birgit C. P., Tibboel, Dick, de Wildt, Saskia N.

“…Background Pediatric drug development is hampered by practical, ethical, and scientific challenges. Microdosing is a promising new method to obtain…”
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Predicting Beta-Lactam Target Non-Attainment in ICU Patients at Treatment Initiation: Development and External Validation of Three Novel (Machine Learning) Models by Wieringa, André, Ewoldt, Tim M J, Gangapersad, Ravish N, Gijsen, Matthias, Parolya, Nestor, Kats, Chantal J A R, Spriet, Isabel, Endeman, Henrik, Haringman, Jasper J, van Hest, Reinier M, Koch, Birgit C P, Abdulla, Alan

“…In the intensive care unit (ICU), infection-related mortality is high. Although adequate antibiotic treatment is essential in infections, beta-lactam target…”
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Meropenem Model-Informed Precision Dosing in the Treatment of Critically Ill Patients: Can We Use It? by Li, Letao, Sassen, Sebastiaan D T, Ewoldt, Tim M J, Abdulla, Alan, Hunfeld, Nicole G M, Muller, Anouk E, de Winter, Brenda C M, Endeman, Henrik, Koch, Birgit C P

“…The number of pharmacokinetic (PK) models of meropenem is increasing. However, the daily role of these PK models in the clinic remains unclear, especially for…”
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Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial by Ewoldt, Tim M. J., Abdulla, Alan, Rietdijk, Wim J. R., Muller, Anouk E., de Winter, Brenda C. M., Hunfeld, Nicole G. M., Purmer, Ilse M., van Vliet, Peter, Wils, Evert-Jan, Haringman, Jasper, Draisma, Annelies, Rijpstra, Tom A., Karakus, Attila, Gommers, Diederik, Endeman, Henrik, Koch, Birgit C. P.

“…Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-lactam antibiotics and ciprofloxacin has been proposed as an…”
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Pharmacodynamics of Flucloxacillin in a Neutropenic Murine Thigh Infection Model: A Piece of the Puzzle towards Evidence-Based Dosing by Roelofsen, Eveline E, de Winter, Brenda C M, van der Spek, Heleen, Snijders, Susan, Koch, Birgit C P, van den Berg, Sanne, Muller, Anouk E

“…For decades, flucloxacillin has been used to treat methicillin-susceptible Staphylococcus aureus (MSSA). Little is still known about its pharmacodynamics (PD)…”
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Gain-of-function single nucleotide variants of the CYP2C19 gene (CYP2C1917) can identify subtherapeutic voriconazole concentrations in critically ill patients: a case series by Weigel, Joachim D., Hunfeld, Nicole G. M., Koch, Birgit C. P., Egal, Mohamud, Bakker, Jan, van Schaik, Ron H. N., van Gelder, Teun

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Using Fluorescence Polarization Immunoassay for Determination of Erythrocyte Methotrexate Polyglutamates, a Quick and Easy Test? by DEN BOER, Ethan, KOCH, Birgit C. P, HUISMAN, Ruud, DE JONGE, Robert

“…The folate antagonist methotrexate (MTX) is the anchor drug in the treatment of rheumatoid arthritis. The therapeutic effects of MTX are attributed to the…”
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Clinical Pharmacokinetics of Fosfomycin after Continuous Infusion Compared with Intermittent Infusion: a Randomized Crossover Study in Healthy Volunteers by Al Jalali, Valentin, Matzneller, Peter, Wulkersdorfer, Beatrix, Chou, Scharon, Bahmany, Soma, Koch, Birgit C P, Zeitlinger, Markus

“…Continuous infusion (CON) of fosfomycin has been proposed as potentially advantageous in certain clinical scenarios. However, no clinical data on the…”
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Failure of target attainment for beta-lactam antibiotics and ciprofloxacin in acute brain-injured intensive care patients by Ergezen, Saliha, Ewoldt, Tim M. J., van der Jagt, Mathieu, Koch, Birgit C. P., Endeman, Henrik

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Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software by Roberts, Jason A., Bellomo, Rinaldo, Cotta, Menino O., Koch, Birgit C. P., Lyster, Haifa, Ostermann, Marlies, Roger, Claire, Shekar, Kiran, Watt, Kevin, Abdul-Aziz, Mohd H.

“…Intensive care unit (ICU) patients with end-organ failure will require specialised machines or extracorporeal therapies to support the failing organs that…”
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Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Development and Validation of Dried Blood Spot-Based Methods for Therapeutic Drug Monitoring by Capiau, Sara, Veenhof, Herman, Koster, Remco A, Bergqvist, Yngve, Boettcher, Michael, Halmingh, Otto, Keevil, Brian G, Koch, Birgit C P, Linden, Rafael, Pistos, Constantinos, Stolk, Leo M, Touw, Daan J, Stove, Christophe P, Alffenaar, Jan-Willem C

“…Dried blood spot (DBS) analysis has been introduced more and more into clinical practice to facilitate Therapeutic Drug Monitoring (TDM). To assure the quality…”
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Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter. Author’s reply by Ewoldt, Tim M. J., Abdulla, Alan, Muller, Anouk E., Endeman, Henrik, Koch, Birgit C. P.

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Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints by de Velde, Femke, de Winter, Brenda C M, Koch, Birgit C P, van Gelder, Teun, Mouton, Johan W

“…To describe the population pharmacokinetics of oral amoxicillin and to compare the PTA of current dosing regimens. Two groups, each with 14 healthy male…”
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