Search Results - "KOCH, Birgit"
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Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Development and Validation of Dried Blood Spot-Based Methods for Therapeutic Drug Monitoring
Published in Therapeutic drug monitoring (01-08-2019)“…Dried blood spot (DBS) analysis has been introduced more and more into clinical practice to facilitate Therapeutic Drug Monitoring (TDM). To assure the quality…”
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Alternative Sampling Devices to Collect Dried Blood Microsamples: State-of-the-Art
Published in Therapeutic drug monitoring (01-06-2021)“…Dried blood spots (DBS) have been used in newborn screening programs for several years. More recently, there has been growing interest in using DBS as a home…”
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Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)
Published in Critical care (London, England) (15-09-2020)“…Abstract Background Early and appropriate antibiotic dosing is associated with improved clinical outcomes in critically ill patients, yet target attainment…”
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Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial
Published in Intensive care medicine (01-12-2022)“…Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-lactam antibiotics and ciprofloxacin has been proposed as an…”
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Clinical Applicability of Monitoring Antihypertensive Drug Levels in Blood
Published in Hypertension (Dallas, Tex. 1979) (01-07-2020)“…Dried blood spot (DBS) analysis is a novel analytical method for therapeutic drug monitoring to identify nonadherence to antihypertensive drugs. This study was…”
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Clinical applications of population pharmacokinetic models of antibiotics: Challenges and perspectives
Published in Pharmacological research (01-08-2018)“…[Display omitted] Because of increasing antimicrobial resistance and the shortage of new antibiotics, there is a growing need to optimize the use of old and…”
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Clinical Pharmacokinetics of Fosfomycin after Continuous Infusion Compared with Intermittent Infusion: a Randomized Crossover Study in Healthy Volunteers
Published in Antimicrobial agents and chemotherapy (16-12-2020)“…Continuous infusion (CON) of fosfomycin has been proposed as potentially advantageous in certain clinical scenarios. However, no clinical data on the…”
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Failure of target attainment for beta-lactam antibiotics and ciprofloxacin in acute brain-injured intensive care patients
Published in Intensive care medicine (01-07-2024)Get full text
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Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software
Published in Intensive care medicine (01-10-2022)“…Intensive care unit (ICU) patients with end-organ failure will require specialised machines or extracorporeal therapies to support the failing organs that…”
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From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics
Published in Clinical pharmacology and therapeutics (01-04-2021)“…Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have evolved as important tools to inform rational dosing of antibiotics in…”
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Stability of 10 Beta-Lactam Antibiotics in Human Plasma at Different Storage Conditions
Published in Therapeutic drug monitoring (01-10-2023)“…Recently, several studies have assessed the effects of therapeutic drug monitoring of frequently prescribed beta-lactam antibiotics, for which they were…”
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Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter. Author’s reply
Published in Intensive care medicine (01-04-2023)Get full text
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Beta-lactam Therapeutic Drug Monitoring in Critically ill Patients: Learnings for Future Research
Published in Clinical infectious diseases (22-08-2023)Get full text
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Assessing methods of measuring medication adherence in chronically ill children-a narrative review
Published in Patient preference and adherence (01-07-2019)“…Nonadherence in children who use long-term medication is a serious problem and assessing adherence is an important step to provide solutions to this problem…”
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Review of the pharmacokinetic properties of nitrofurantoin and nitroxoline
Published in Journal of antimicrobial chemotherapy (01-11-2018)“…Nitrofurantoin and nitroxoline are oral antibiotics for the treatment or prophylaxis of acute urinary tract infections. New interest in both these drugs is…”
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Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentrations
Published in The AAPS journal (01-02-2024)“…Special populations, like geriatric patients, experience altered paracetamol pharmacokinetics (PK), complicating pain management. More PK research is essential…”
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Optimal Practice for Vancomycin Therapeutic Drug Monitoring: Position Statement From the Anti-infectives Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology
Published in Therapeutic drug monitoring (01-02-2022)“…Individualization of vancomycin dosing based on therapeutic drug monitoring (TDM) data is known to improve patient outcomes compared with fixed or empirical…”
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Barriers and Facilitators in the Clinical Implementation of Beta-Lactam Therapeutic Drug Monitoring in Critically Ill Patients: A Critical Review
Published in Therapeutic drug monitoring (01-02-2022)“…With increasing knowledge of beta-lactam pharmacodynamics and interpatient and intrapatient variability in pharmacokinetics, the usefulness of therapeutic drug…”
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Population plasma and urine pharmacokinetics and the probability of target attainment of fosfomycin in healthy male volunteers
Published in European journal of clinical pharmacology (01-06-2023)“…Purpose A population pharmacokinetic model of fosfomycin was developed in healthy volunteers after intravenous administration, and different dosing regimens…”
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Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins
Published in The EMBO journal (15-12-2017)“…Mammalian genomes are spatially organized into compartments, topologically associating domains (TADs), and loops to facilitate gene regulation and other…”
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