Search Results - "KOBAYASHI, Takaaki"

First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors by Okano, Naohiro, Naruge, Daisuke, Kawai, Kirio, Kobayashi, Takaaki, Nagashima, Fumio, Endou, Hitoshi, Furuse, Junji

“…Summary This open-label first-in-human study evaluated JPH203, which is a novel selective L-type amino acid transporter 1 inhibitor. We also evaluated the…”
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Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)–H Bond Activation To Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes by Hoshiya, Naoyuki, Kobayashi, Takaaki, Arisawa, Mitsuhiro, Shuto, Satoshi

“…Pd(II)-catalyzed tertiary C(sp3)–H arylation of cyclopropanes via directing group-mediated C–H activation for the construction of a chiral quaternary carbon…”
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Dimeric transport mechanism of human vitamin C transporter SVCT1 by Kobayashi, Takaaki A., Shimada, Hiroto, Sano, Fumiya K., Itoh, Yuzuru, Enoki, Sawako, Okada, Yasushi, Kusakizako, Tsukasa, Nureki, Osamu

“…Vitamin C plays important roles as a cofactor in many enzymatic reactions and as an antioxidant against oxidative stress. As some mammals including humans…”
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An autopsy case study of lymphocytic hypophysitis induced by nivolumab treatment for esophageal malignant melanoma by Okabe, Naota, Kobayashi, Takaaki, Furuse, Junji, Fujiwara, Masachika, Kamma, Hiroshi

“…Immune checkpoint inhibitors such as anti‐cytotoxic T‐lymphocyte antigen‐4 and anti‐programmed death‐1 antibodies are effective against malignant tumors…”
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Prevalence of Anal Dysplasia in Human Immunodeficiency Virus–Infected Transgender Women by Kobayashi, Takaaki, Sigel, Keith, Gaisa, Michael

“…Although human immunodeficiency virus–infected men who have sex with men are at high risk for anal cancer, little is known about the prevalence of anal…”
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Viral exanthem in a healthy adult with rotavirus gastroenteritis by Kobayashi, Takaaki, Brust, Karen

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Current activity of xenotransplantation in Japan by Kobayashi, Takaaki, Miyagawa, Shuji

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Short-term effectiveness of COVID-19 vaccines in immunocompromised patients: A systematic literature review and meta-analysis by Marra, Alexandre R., Kobayashi, Takaaki, Suzuki, Hiroyuki, Alsuhaibani, Mohammed, Tofaneto, Bruna Marques, Bariani, Luigi Makowski, Auler, Mariana de Amorim, Salinas, Jorge L., Edmond, Michael B., Doll, Michelle, Kutner, José Mauro, Pinho, João Renato Rebello, Rizzo, Luiz Vicente, Miraglia, João Luiz, Schweizer, Marin L.

“…•We performed a systematic review and meta-analysis of 33 observational studies.•All COVID-19 vaccine studies compared immunocompromised patients vs. control…”
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Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker by Takawa, Masashi, Masuda, Ken, Kunizaki, Masaki, Daigo, Yataro, Takagi, Katsunori, Iwai, Yukiko, Cho, Hyun‐Soo, Toyokawa, Gouji, Yamane, Yuka, Maejima, Kazuhiro, Field, Helen I., Kobayashi, Takaaki, Akasu, Takayuki, Sugiyama, Masanori, Tsuchiya, Eijyu, Atomi, Yutaka, Ponder, Bruce A. J., Nakamura, Yusuke, Hamamoto, Ryuji

“…The emphasis in anticancer drug discovery has always been on finding a drug with great antitumor potential but few side‐effects. This can be achieved if the…”
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Disseminated histoplasmosis presenting as bilateral lower extremity paresis by Simms, Andrew, Kobayashi, Takaaki, Endelman, Levi, Sekar, Poorani

“…•Disseminated histoplasmosis is a rare entity that occurs as a result of hematogenous spread of the organism within macrophages during acute infection. Risk…”
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Mapping the distribution of Lyme disease at a mid-Atlantic site in the United States using electronic health data by Lantos, Paul M, Janko, Mark, Nigrovic, Lise E, Ruffin, Felicia, Kobayashi, Takaaki, Higgins, Yvonne, Auwaerter, Paul G

“…Lyme disease is a spatially heterogeneous tick-borne infection, with approximately 85% of US cases concentrated in the mid-Atlantic and northeastern states…”
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De Novo Anti-HLA DSA Characteristics and Subclinical Antibody-Mediated Kidney Allograft Injury by Yamamoto, Takayuki, Watarai, Yoshihiko, Takeda, Asami, Tsujita, Makoto, Hiramitsu, Takahisa, Goto, Norihiko, Narumi, Shunji, Katayama, Akio, Morozumi, Kunio, Uchida, Kazuharu, Kobayashi, Takaaki

“…BACKGROUNDIt is unclear whether all donor-specific antibodies (DSA) can cause chronic antibody-mediated rejection (AMR). Subclinical stage before manifestation…”
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Clinical image: chronic skin ulcers in a patient with rheumatoid arthritis on immunosuppressant therapy by Kobayashi, Takaaki, Swick, Brian L., Cho, Christine

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Current status of pig kidney xenotransplantation by Iwase, Hayato, Kobayashi, Takaaki

“…Abstract Significant progress in life-supporting kidney xenograft survival in nonhuman primates (NHPs) has been associated largely with the increasing…”
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Influence of Dissolved Hydrogen Concentration on the Protective Property of Oxide Film of Alloy 600 Against Primary Water Stress Corrosion Cracking by Kakitani, Kenta, Kobayashi, Takaaki, Sato, Kenji, Sugino, Wataru, Nakano, Yusuke, Shoji, Tetsuo, Abe, Hiroaki

“…Primary water stress corrosion cracking (PWSCC) of Alloy 600 has been a key issue in the field of nuclear energy. It is well known that dissolved hydrogen (DH)…”
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Conformational Restriction of Histamine with a Rigid Bicyclo[3.1.0]hexane Scaffold Provided Selective H3 Receptor Ligands by Watanabe, Mizuki, Kobayashi, Takaaki, Ito, Yoshihiko, Yamada, Shizuo, Shuto, Satoshi

“…We designed and synthesized conformationally rigid histamine analogues with a bicyclo[3.1.0]hexane scaffold. All the compounds were selectively bound to the H3…”
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Regulation of Clinical Xenotransplantation—Time for a Reappraisal by Cooper, David K.C, Pierson, Richard N, Hering, Bernhard J, Mohiuddin, Muhammad M, Fishman, Jay A, Denner, Joachim, Ahn, Curie, Azimzadeh, Agnes M, Buhler, Leo H, Cowan, Peter J, Hawthorne, Wayne J, Kobayashi, Takaaki, Sachs, David H

“…ABSTRACTThe continual critical shortage of organs and cells from deceased human donors has stimulated research in the field of cross-species transplantation…”
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Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression by TAKAWA, Masashi, CHO, Hyun-Soo, DOHMAE, Naoshi, FIELD, Helen I, TSUNODA, Tatsuhiko, KOBAYASHI, Takaaki, AKASU, Takayuki, SUGIYAMA, Masanori, OHNUMA, Shin-Ichi, ATOMI, Yutaka, PONDER, Bruce A. J, NAKAMURA, Yusuke, HAYAMI, Shinya, HAMAMOTO, Ryuji, TOYOKAWA, Gouji, KOGURE, Masaharu, YAMANE, Yuka, IWAI, Yukiko, MAEJIMA, Kazuhiro, UEDA, Koji, MASUDA, Akiko

“…Although the physiologic significance of lysine methylation of histones is well known, whether lysine methylation plays a role in the regulation of nonhistone…”
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“Emerging Donors” from a Recipient Perspective: An Institutional Analysis of Foreign Aid in Cambodia by Sato, Jin, Shiga, Hiroaki, Kobayashi, Takaaki, Kondoh, Hisahiro

“…Debate about the impact of so-called “emerging donors” is becoming increasingly heated. The common reaction to these donors, as distinct from that accorded to…”
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Hip periprosthetic joint infection due to Coxiella burnetii in an adult male by Kidder, Ian, Kobayashi, Takaaki, Ford, Bradley, Sekar, Poorani

“…Coxiella burnetii is an obligate intracellular Gram-negative bacterium. “Query fever” (Q fever) first described in 1939 is a disease caused by Coxiella…”
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