Search Results - "KOBAYASHI, Dale K"

Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma by Johanns, Tanner M, Miller, Christopher A, Liu, Connor J, Perrin, Richard J, Bender, Diane, Kobayashi, Dale K, Campian, Jian L, Chicoine, Michael R, Dacey, Ralph G, Huang, Jiayi, Fritsch, Edward F, Gillanders, William E, Artyomov, Maxim N, Mardis, Elaine R, Schreiber, Robert D, Dunn, Gavin P

“…Neoantigens represent promising targets for personalized cancer vaccine strategies. However, the feasibility of this approach in lower mutational burden tumors…”
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The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema by ATKINSON, Jeffrey J, LUTEY, Barbara A, CONRADI, Susan H, GIERADA, David S, PIERCE, Richard A, BETSUYAKU, Tomoko, SENIOR, Robert M, SUZUKI, Yoko, TOENNIES, Holly M, KELLEY, Diane G, KOBAYASHI, Dale K, IJEM, Whitney G, DESLEE, Gaetan, MOORE, Carla H, EILEEN JACOBS, M

“…Matrix metalloprotease (MMP)-9 is an elastolytic endopeptidase produced by activated macrophages that may be involved in the development of human pulmonary…”
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Neutrophil Elastase Contributes to Cigarette Smoke-Induced Emphysema in Mice by Shapiro, Steven D., Goldstein, Nir M., Houghton, A. McGarry, Kobayashi, Dale K., Kelley, Diane, Belaaouaj, Abderazzaq

“…To address the role of neutrophil elastase in pulmonary emphysema, neutrophil elastase-deficient mice and wild-type littermate controls were exposed to…”
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Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases by MCGARRY HOUGHTON, A, GRISOLANO, Jay L, BAUMANN, Mary L, KOBAYASHI, Dale K, HAUTAMAKI, R. Dean, NEHRING, Leslie C, CORNELIUS, Lynn A, SHAPIRO, Steven D

“…Matrix metalloproteinases (MMP) have been implicated in virtually all aspects of tumor progression. However, the recent failure of clinical trials employing…”
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High incidence of TERT mutation in brain tumor cell lines by Johanns, Tanner M., Fu, Yujie, Kobayashi, Dale K., Mei, Yu, Dunn, Ian F., Mao, Diane D., Kim, Albert H., Dunn, Gavin P.

“…TERT promoter gene mutations are highly recurrent in malignant glioma. However, little information exists regarding their presence in experimental brain tumor…”
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TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma by Schaettler, Maximilian O, Desai, Rupen, Wang, Anthony Z, Livingstone, Alexandra J, Kobayashi, Dale K, Coxon, Andrew T, Bowman-Kirigin, Jay A, Liu, Connor J, Li, Mao, Bender, Diane E, White, Michael J, Kranz, David M, Johanns, Tanner M, Dunn, Gavin P

“…BackgroundAdoptive cellular therapies with chimeric antigen receptor T cells have revolutionized the treatment of some malignancies but have shown limited…”
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Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice by Hautamaki, R. Dean, Kobayashi, Dale K., Senior, Robert M., Shapiro, Steven D.

“…To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase-deficient (MME$^{-/-}$) mice…”
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Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization by Cornelius, Lynn A, Nehring, Leslie C, Harding, Elizabeth, Bolanowski, Mark, Welgus, Howard G, Kobayashi, Dale K, Pierce, Richard A, Shapiro, Steven D

“…Angiostatin, a cleavage product of plasminogen, has been shown to inhibit endothelial cell proliferation and metastatic tumor cell growth. Recently, the…”
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Treatment of an aggressive orthotopic murine glioblastoma model with combination checkpoint blockade and a multivalent neoantigen vaccine by Liu, Connor J, Schaettler, Maximilian, Blaha, Dylan T, Bowman-Kirigin, Jay A, Kobayashi, Dale K, Livingstone, Alexandra J, Bender, Diane, Miller, Christopher A, Kranz, David M, Johanns, Tanner M, Dunn, Gavin P

“…Abstract Background Although clinical trials testing immunotherapies in glioblastoma (GBM) have yielded mixed results, new strategies targeting tumor-specific…”
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Endogenous Neoantigen-Specific CD8 T Cells Identified in Two Glioblastoma Models Using a Cancer Immunogenomics Approach by Johanns, Tanner M, Ward, Jeffrey P, Miller, Christopher A, Wilson, Courtney, Kobayashi, Dale K, Bender, Diane, Fu, Yujie, Alexandrov, Anton, Mardis, Elaine R, Artyomov, Maxim N, Schreiber, Robert D, Dunn, Gavin P

“…The "cancer immunogenomics" paradigm has facilitated the search for tumor-specific antigens over the last 4 years by applying comprehensive cancer genomics to…”
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GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors by Fu, Yujie, Liu, Connor J., Kobayashi, Dale K., Johanns, Tanner M., Bowman-Kirigin, Jay A., Schaettler, Maximilian O., Mao, Diane D., Bender, Diane, Kelley, Diane G., Uppaluri, Ravindra, Bi, Wenya Linda, Dunn, Ian F., Tao, Yu, Luo, Jingqin, Kim, Albert H., Dunn, Gavin P.

“…Encouraging clinical results using immune checkpoint therapies to target the PD-1 axis in a variety of cancer types have paved the way for new immune therapy…”
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Accelerated enlargement of experimental abdominal aortic aneurysms in a mouse model of chronic cigarette smoke exposure by Buckley, Celine, Wyble, Charles W., Borhani, Martin, Ennis, Terri L., Kobayashi, Dale K., Curci, John A., Shapiro, Steven D., Thompson, Robert W.

“…Cigarette smoking and pulmonary emphysema are strongly associated with abdominal aortic aneurysms (AAAs), but the biologic mechanisms linking these conditions…”
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Elastin fragments drive disease progression in a murine model of emphysema by Houghton, A McGarry, Quintero, Pablo A, Perkins, David L, Kobayashi, Dale K, Kelley, Diane G, Marconcini, Luiz A, Mecham, Robert P, Senior, Robert M, Shapiro, Steven D

“…Mice lacking macrophage elastase (matrix metalloproteinase-12, or MMP-12) were previously shown to be protected from the development of cigarette smoke-induced…”
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The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain by Bowman-Kirigin, Jay A, Desai, Rupen, Saunders, Brian T, Wang, Anthony Z, Schaettler, Maximilian O, Liu, Connor J, Livingstone, Alexandra J, Kobayashi, Dale K, Durai, Vivek, Kretzer, Nicole M, Zipfel, Gregory J, Leuthardt, Eric C, Osbun, Joshua W, Chicoine, Michael R, Kim, Albert H, Murphy, Kenneth M, Johanns, Tanner M, Zinselmeyer, Bernd H, Dunn, Gavin P

“…The central nervous system (CNS) antigen-presenting cell (APC) that primes antitumor CD8+ T-cell responses remains undefined. Elsewhere in the body, the…”
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Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts by Deslee, Gaetan, Adair-Kirk, Tracy L, Betsuyaku, Tomoko, Woods, Jason C, Moore, Carla H, Gierada, David S, Conradi, Susan H, Atkinson, Jeffrey J, Toennies, Holly M, Battaile, John T, Kobayashi, Dale K, Patterson, G Alexander, Holtzman, Michael J, Pierce, Richard A

“…Oxidative stress is widely proposed as a pathogenic mechanism for chronic obstructive pulmonary disease (COPD), but the molecular pathway connecting oxidative…”
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143 Identification of Neoantigen-specific CD8+ T Cells in Two Murine Orthotopic Glioblastoma Models Using Cancer Immunogenomics by Johanns, Tanner M., Ward, Jeffrey, Wilson, Courtney, Kobayashi, Dale K., Bender, Diane, Fu, Yujie, Alexandrov, Anton, Artyomov, Maxim N., Miller, Chris A., Mardis, Elaine R., Dunn, Gavin P.

“…Abstract INTRODUCTION: Our understanding of how immune-based strategies designed to enhance T-cell activation might effectively control glioblastoma…”
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Hyperpolarized (3)He MRI of mouse lung by Dugas, Joseph P, Garbow, Joel R, Kobayashi, Dale K, Conradi, Mark S

“…Hyperpolarized (3)He images of mouse lung are presented. Ventilation images and measurements of (3)He apparent diffusion coefficient (ADC) are reported in…”
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Metalloelastase is Required for Macrophage-Mediated Proteolysis and Matrix Invasion in Mice by Shipley, J. Michael, Wesselschmidt, Robin L., Kobayashi, Dale K., Ley, Timothy J., Shapiro, Steven D.

“…Macrophages secrete a variety of proteinases that are thought to participate in remodeling of the extracellular matrix associated with inflammatory processes…”
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Hydrolysis of a Broad Spectrum of Extracellular Matrix Proteins by Human Macrophage Elastase by Gronski, Jr, T J, Martin, R L, Kobayashi, D K, Walsh, B C, Holman, M C, Huber, M, Van Wart, H E, Shapiro, S D

“…Macrophage elastase (ME) was originally named when metal-dependent elastolytic activity was detected in conditioned media of murine macrophages. Subsequent…”
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Human Macrophage Metalloelastase. GENOMIC ORGANIZATION, CHROMOSOMAL LOCATION, GENE LINKAGE, AND TISSUE-SPECIFIC EXPRESSION by Belaaouaj, Azzaq, Shipley, J. Michael, Kobayashi, Dale K., Zimonjic, Drazen B., Popescu, Nicholas, Silverman, Gary A., Shapiro, Steven D.

“…Human macrophage metalloelastase (HME) is a recent addition to the matrix metalloproteinase (MMP) family that was initially found to be expressed in alveolar…”
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