Search Results - "KNUECHEL, Ruth"

EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer by Rose, Michael, Maurer, Angela, Wirtz, Julia, Bleilevens, Andreas, Waldmann, Tanja, Wenz, Maximilian, Eyll, Marie, Geelvink, Mirja, Gereitzig, Melanie, Rüchel, Nadine, Denecke, Bernd, Eltze, Elke, Herrmann, Edwin, Toma, Marieta, Horst, David, Grimm, Tobias, Denzinger, Stefan, Ecke, Thorsten, Vögeli, Thomas Alexander, Knuechel, Ruth, Maurer, Jochen, Gaisa, Nadine T.

“…Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle-invasive bladder cancer (MIBC). However, the impact on bladder cancer with…”
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Quantitative Micro-Computed Tomography Imaging of Vascular Dysfunction in Progressive Kidney Diseases by Ehling, Josef, Bábíčková, Janka, Gremse, Felix, Klinkhammer, Barbara M, Baetke, Sarah, Knuechel, Ruth, Kiessling, Fabian, Floege, Jürgen, Lammers, Twan, Boor, Peter

“…Progressive kidney diseases and renal fibrosis are associated with endothelial injury and capillary rarefaction. However, our understanding of these processes…”
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Expression of programmed death ligand (PD-L1) in different tumors. Comparison of several current available antibody clones and antibody profiling by Kintsler, Svetlana, Cassataro, Maria Angela, Drosch, Michael, Holenya, Pavlo, Knuechel, Ruth, Braunschweig, Till

“…PD-L1 is a surface molecule which is expressed on different types of cells, including antigen presenting cells, vascular endothelial cells and other cells of…”
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Comparative genomic profiling of glandular bladder tumours by Maurer, Angela, Ortiz-Bruechle, Nadina, Guricova, Karolina, Rose, Michael, Morsch, Ronja, Garczyk, Stefan, Stöhr, Robert, Bertz, Simone, Golz, Reinhard, Reis, Henning, Bremmer, Felix, Zimpfer, Annette, Siegert, Sabine, Kristiansen, Glen, Schwamborn, Kristina, Gassler, Nikolaus, Knuechel, Ruth, Gaisa, Nadine T.

“…Primary glandular bladder tumours (bladder adenocarcinoma [BAC], urachal adenocarcinoma [UAC], urothelial carcinoma with glandular differentiation [UCg]) are…”
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Characterisation of tumour-immune phenotypes and PD-L1 positivity in squamous bladder cancer by Jung, Max, Rose, Michael, Knuechel, Ruth, Loeffler, Chiara, Muti, Hannah, Kather, Jakob Nikolas, Gaisa, Nadine T

“…Immune checkpoint inhibitor (ICI) therapy has become a viable treatment strategy in bladder cancer. However, treatment responses vary, and improved biomarkers…”
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Clinically Relevant Reduction in Risk of Recurrence of Superficial Bladder Cancer Using 5-Aminolevulinic Acid-Induced Fluorescence Diagnosis: 8-Year Results of Prospective Randomized Study by Denzinger, Stefan, Burger, Maximilian, Walter, Bernhard, Knuechel, Ruth, Roessler, Wolfgang, Wieland, Wolf F, Filbeck, Thomas

“…Objectives Several studies have shown that 5-aminolevulinic acid (5-ALA)-induced fluorescence cystoscopy improves the detection of superficial bladder cancer…”
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Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis by Hamm, Alexander, Veeck, Juergen, Bektas, Nuran, Wild, Peter J, Hartmann, Arndt, Heindrichs, Uwe, Kristiansen, Glen, Werbowetski-Ogilvie, Tamra, Del Maestro, Rolando, Knuechel, Ruth, Dahl, Edgar

“…The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain - bikunin, encoded by AMBP - and five…”
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Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer by Fischbach, Anna, Rogler, Anja, Erber, Ramona, Stoehr, Robert, Poulsom, Richard, Heidenreich, Axel, Schneevoigt, Birte-Swantje, Hauke, Sven, Hartmann, Arndt, Knuechel, Ruth, Veeck, Jürgen, Gaisa, Nadine T

“…Aims Activating point mutations and protein overexpression of fibroblast growth factor receptors (FGFRs), especially FGFR3, are frequent events in bladder…”
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Diagnostic and Prognostic Implications of FGFR3high/Ki67high Papillary Bladder Cancers by Geelvink, Mirja, Babmorad, Armin, Maurer, Angela, Stöhr, Robert, Grimm, Tobias, Bach, Christian, Knuechel, Ruth, Rose, Michael, Gaisa, Nadine

“…Prognostic/therapeutic stratification of papillary urothelial cancers is solely based upon histology, despite activated FGFR3-signaling was found to be…”
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Variable β-Catenin Expression in Colorectal Cancers Indicates Tumor Progression Driven by the Tumor Environment by Brabletz, Thomas, Jung, Andreas, Reu, Simone, Porzner, Marc, Hlubek, Falk, Kunz-Schughart, Leoni A., Knuechel, Ruth, Kirchner, Thomas

“…Invasion and dissemination of well-differentiated carcinomas are often associated with loss of epithelial differentiation and gain of mesenchyme-like…”
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Fibroblast growth factor receptor (FGFR) alterations in squamous differentiated bladder cancer: a putative therapeutic target for a small subgroup by Baldia, Philipp H, Maurer, Angela, Heide, Timon, Rose, Michael, Stoehr, Robert, Hartmann, Arndt, Williams, Sarah V, Knowles, Margaret A, Knuechel, Ruth, Gaisa, Nadine T

“…Although drugable fibroblast growth factor receptor (FGFR) alterations in squamous cell carcinomas (SCC) of various entities are well known, little is known…”
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Clonal architecture of human prostatic epithelium in benign and malignant conditions by Gaisa, Nadine T, Graham, Trevor A, McDonald, Stuart AC, Poulsom, Richard, Heidenreich, Axel, Jakse, Gerhard, Knuechel, Ruth, Wright, Nicholas A

“…The location of stem cells in the epithelium of the prostatic acinus remains uncertain, as does the cellular origin of prostatic neoplasia. Here, we apply…”
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Presence of TERT Promoter Mutations is a Secondary Event and Associates with Elongated Telomere Length in Myxoid Liposarcomas by Ferreira, Monica S Ventura, Crysandt, Martina, Braunschweig, Till, Jost, Edgar, Voss, Barbara, Bouillon, Anne-Sophie, Knuechel, Ruth, Brümmendorf, Tim H, Beier, Fabian

“…The occurrence of promoter mutations has been well described in soft tissue sarcomas (STS). However, the biological role of these mutations as well as their…”
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The human urothelium consists of multiple clonal units, each maintained by a stem cell by Gaisa, Nadine T, Graham, Trevor A, McDonald, Stuart AC, Cañadillas-Lopez, Sagrario, Poulsom, Richard, Heidenreich, Axel, Jakse, Gerhard, Tadrous, Paul J, Knuechel, Ruth, Wright, Nicholas A

“…Little is known about the clonal architecture of human urothelium. It is likely that urothelial stem cells reside within the basal epithelial layer, yet…”
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Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies by Hafner, Christian, Knuechel, Ruth, Stoehr, Robert, Hartmann, Arndt

“…Multifocal occurrence and frequent recurrence are characteristic features of urothelial carcinomas of both the urinary bladder and the upper urinary tract. To…”
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WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer by Wissmann, Christoph, Wild, Peter Johannes, Kaiser, Simone, Roepcke, Stefan, Stoehr, Robert, Woenckhaus, Matthias, Kristiansen, Glen, Hsieh, Jen-Chih, Hofstaedter, Ferdinand, Hartmann, Arndt, Knuechel, Ruth, Rosenthal, André, Pilarsky, Christian

“…To detect novel Wnt‐pathway genes involved in tumourigenesis, this study analysed the RNA expression levels of 40 genes of the Wnt pathway by chip…”
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Molecular Profiling of Laser-Microdissected Matched Tumor and Normal Breast Tissue Identifies Karyopherin α2 as a Potential Novel Prognostic Marker in Breast Cancer by Dahl, Edgar, Kristiansen, Glen, Gottlob, Kathrin, Klaman, Irina, Ebner, Elke, Hinzmann, Bernd, Hermann, Klaus, Pilarsky, Christian, Dürst, Matthias, Klinkhammer-Schalke, Monika, Blaszyk, Hagen, Knuechel, Ruth, Hartmann, Arndt, Rosenthal, André, Wild, Peter J.

“…Purpose: The aim of the present study was to identify human genes that might prove useful in the diagnosis and therapy of primary breast cancer. Experimental…”
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Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract by HAFNER, Christian, KNUECHEL, Ruth, ZANARDO, Livia, DIETMAIER, Wolfgang, BLASZYK, Hagen, CHEVILLE, John, HOFSTAEDTER, Ferdinand, HARTMANN, Arndt

“…Multifocality and recurrence of urothelial carcinoma may result from either the field effect of carcinogens leading to oligoclonal tumors or monoclonal tumor…”
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Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa by Rogler, Gerhard, Brand ‡, Korbinian, Vogl, Daniela, Page ‡, Sharon, Hofmeister, Robert, Andus, Tilo, Knuechel §, Ruth, Baeuerle ∥, Patrick A., Schölmerich, Jürgen, Gross, Volker

“…Background & Aims: Transcription factors of the nuclear factor κB (NF-κB) family play an important role in the regulation of genes involved in inflammation. In…”
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Gene Expression Profiling of Progressive Papillary Noninvasive Carcinomas of the Urinary Bladder by WILD, Peter J, HERR, Alexander, WISSMANN, Christoph, STOEHR, Robert, ROSENTHAL, Andre, ZAAK, Dirk, SIMON, Ronald, KNUECHEL, Ruth, PILARSKY, Christian, HARTMANN, Arndt

“…Purpose: The aim of the present study was to define gene expression profiles of noninvasive and invasive bladder cancer, to identify potential therapeutic or…”
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