Search Results - "KNOWLTON, Kirk U"

Economics and outcomes of sotalol in‐patient dosing approaches in patients with atrial fibrillation by Varela, Daniel L., Burnham, Tyson S., May, Heidi, Bair, Tami, Steinberg, Benjamin A., Muhlestein, Joseph, Anderson, Jeffrey, Knowlton, Kirk, Bunch, Thomas

“…Introduction There exists variability in the administration of in‐patient sotalol therapy for symptomatic atrial fibrillation (AF). The impact of this…”
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Periodic Fasting and Acute Cardiac Events in Patients Evaluated for COVID-19: An Observational Prospective Cohort Study by Horne, Benjamin D, Anderson, Jeffrey L, Haddad, Francois, May, Heidi T, Le, Viet T, Knight, Stacey, Bair, Tami L, Knowlton, Kirk U

“…Periodic fasting was previously associated with greater longevity and a lower incidence of heart failure (HF) in a pre-pandemic population. In patients with…”
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Validation of an Integrated Genetic-Epigenetic Test for the Assessment of Coronary Heart Disease by Philibert, Robert, Dogan, Timur K, Knight, Stacey, Ahmad, Ferhaan, Lau, Stanley, Miles, George, Knowlton, Kirk U, Dogan, Meeshanthini V

“…Coronary heart disease (CHD) is the leading cause of death in the world. Unfortunately, many of the key diagnostic tools for CHD are insensitive, invasive, and…”
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Impact of anticoagulation therapy on the cognitive decline and dementia in patients with non‐valvular atrial fibrillation (cognitive decline and dementia in patients with non‐valvular atrial fibrillation [CAF] trial) by Bunch, Thomas Jared, May, Heidi, Cutler, Michael, Woller, Scott C., Jacobs, Victoria, Stevens, Scott M., Carlquist, John, Knowlton, Kirk U., Muhlestein, Joseph B., Steinberg, Benjamin A., Anderson, Jeffrey L.

“…Background Atrial fibrillation (AF) is associated with a risk for cognitive impairment and dementia, which is more pronounced in patients with a history of…”
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Pathogenesis of SARS-CoV-2 induced cardiac injury from the perspective of the virus by Knowlton, Kirk U.

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A highly predictive cardiac positron emission tomography (PET) risk score for 90-day and one-year major adverse cardiac events and revascularization by McCubrey, Raymond O., Mason, Steve M., Le, Viet T., Bride, Daniel L., Horne, Benjamin D., Meredith, Kent G., Sekaran, Nishant K., Anderson, Jeffrey L., Knowlton, Kirk U., Min, David B., Knight, Stacey

“…With the increase in cardiac PET/CT availability and utilization, the development of a PET/CT-based major adverse cardiovascular events, including death,…”
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Cardiac-Specific Deletion of SOCS-3 Prevents Development of Left Ventricular Remodeling After Acute Myocardial Infarction by Oba, Toyoharu, MD, Yasukawa, Hideo, MD, PhD, Hoshijima, Masahiko, MD, PhD, Sasaki, Ken-ichiro, MD, PhD, Futamata, Nobuyoshi, MD, Fukui, Daisuke, MD, Mawatari, Kazutoshi, MD, Nagata, Takanobu, MD, Kyogoku, Sachiko, MD, Ohshima, Hideki, MD, Minami, Tomoko, MD, Nakamura, Keiichiro, MD, PhD, Kang, Dongchon, MD, PhD, Yajima, Toshitaka, MD, PhD, Knowlton, Kirk U., MD, Imaizumi, Tsutomu, MD, PhD

“…Objectives The study investigated the role of myocardial suppressor of cytokine signaling-3 (SOCS3), an intrinsic negative feedback regulator of the janus…”
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Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle by Bang, Marie-Louise, Li, Xiaodong, Littlefield, Ryan, Bremner, Shannon, Thor, Andrea, Knowlton, Kirk U, Lieber, Richard L, Chen, Ju

“…Nebulin is a giant modular sarcomeric protein that has been proposed to play critical roles in myofibrillogenesis, thin filament length regulation, and muscle…”
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Loss of Enigma Homolog Protein Results in Dilated Cardiomyopathy by Cheng, Hongqiang, Kimura, Kensuke, Peter, Angela K, Cui, Li, Ouyang, Kunfu, Shen, Tao, Liu, Yujie, Gu, Yusu, Dalton, Nancy D, Evans, Sylvia M, Knowlton, Kirk U, Peterson, Kirk L, Chen, Ju

“…RATIONALE:The Z-line, alternatively termed the Z-band or Z-disc, is a highly ordered structure at the border between 2 sarcomeres. Enigma subfamily proteins…”
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Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy by Lim, Byung-Kwan, Peter, Angela K, Xiong, Dingding, Narezkina, Anna, Yung, Aaron, Dalton, Nancy D, Hwang, Kyung-Kuk, Yajima, Toshitaka, Chen, Ju, Knowlton, Kirk U

“…Heart failure in children and adults is often the consequence of myocarditis associated with Coxsackievirus (CV) infection. Upon CV infection, enteroviral…”
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Preferential Metabolic Improvement by Intermittent Fasting in People with Elevated Baseline Red Cell Distribution Width: A Secondary Analysis of the WONDERFUL Randomized Controlled Trial by Horne, Benjamin D, Muhlestein, Joseph B, May, Heidi T, Le, Viet T, Bair, Tami L, Bennett, Sterling T, Knowlton, Kirk U, Anderson, Jeffrey L

“…Red cell distribution width (RDW) predicts cardiovascular outcomes, but it is unstudied with regard to intermittent fasting. In WONDERFUL trial subjects, the…”
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Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure by Zhang, Zhiyuan, Mu, Yongxin, Veevers, Jennifer, Peter, Angela K, Manso, Ana Maria, Bradford, William H, Dalton, Nancy D, Peterson, Kirk L, Knowlton, Kirk U, Ross, Robert S, Zhou, Xinmin, Chen, Ju

“…The striated muscle costamere, a multiprotein complex at the boundary between the sarcomere and the sarcolemma, plays an integral role in maintaining striated…”
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Insights From a Murine Model of Coronavirus Disease 2019 (COVID-19) mRNA Vaccination-Induced Myopericarditis: Could Accidental Intravenous Vaccine Injection Induce Myopericarditis? by Knowlton, Kirk U

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Association of periodic fasting with lower severity of COVID-19 outcomes in the SARS-CoV-2 prevaccine era: an observational cohort from the INSPIRE registry by Horne, Benjamin D, May, Heidi T, Muhlestein, Joseph B, Le, Viet T, Bair, Tami L, Knowlton, Kirk U, Anderson, Jeffrey L

“…ObjectivesIntermittent fasting boosts some host defence mechanisms while modulating the inflammatory response. Lower-frequency fasting is associated with…”
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Increased Echogenicity and Radiodense Foci on Echocardiogram and MicroCT in Murine Myocarditis by Peter, Angela K, Bradford, William H, Dalton, Nancy D, Gu, Yusu, Chao, Chieh-Ju, Peterson, Kirk L, Knowlton, Kirk U

“…To address the question as to whether echocardiographic and/or microcomputed tomography (microCT) analysis can be utilized to assess the extent of Coxsackie B…”
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Atrial fibrillation is a risk factor for major adverse cardiovascular events in COVID-19 by Cutler, Michael J., May, Heidi T., Bair, Tami L., Crandall, Brian G., Osborn, Jeffrey S., Miller, Jared D., Mallender, Charles D., Muhlestein, Joseph B., Anderson, Jeffrey L., Knowlton, Kirk U., Knight, Stacey

“…New-onset atrial fibrillation (AF) during COVID-19 infection is associated with worse cardiovascular outcomes and mortality, with new-onset AF being associated…”
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Approaching Higher Dimension Imaging Data Using Cluster-Based Hierarchical Modeling in Patients with Heart Failure Preserved Ejection Fraction by Kobayashi, Yukari, Tremblay-Gravel, Maxime, Boralkar, Kalyani A., Li, Xiao, Nishi, Tomoko, Amsallem, Myriam, Moneghetti, Kegan J., Bouajila, Sara, Selej, Mona, Ozen, Mehmet O., Demirci, Utkan, Ashley, Euan, Wheeler, Matthew, Knowlton, Kirk U., Kouznetsova, Tatiana, Haddad, Francois

“…Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality, accounting for the majority of heart failure (HF)…”
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Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells by Veevers, Jennifer, Farah, Elie N., Corselli, Mirko, Witty, Alec D., Palomares, Karina, Vidal, Jason G., Emre, Nil, Carson, Christian T., Ouyang, Kunfu, Liu, Canzhao, van Vliet, Patrick, Zhu, Maggie, Hegarty, Jeffrey M., Deacon, Dekker C., Grinstein, Jonathan D., Dirschinger, Ralf J., Frazer, Kelly A., Adler, Eric D., Knowlton, Kirk U., Chi, Neil C., Martin, Jody C., Chen, Ju, Evans, Sylvia M.

“…To facilitate understanding of human cardiomyocyte (CM) subtype specification, and the study of ventricular CM biology in particular, we developed a broadly…”
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The costamere bridges sarcomeres to the sarcolemma in striated muscle by Peter, Angela K, Cheng, Hongqiang, Ross, Robert S, Knowlton, Kirk U, Chen, Ju

“…Abstract Costameres are sub-membranous, Z-line associated structures found in striated muscle. They have been shown to have important roles in transmission of…”
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Association of the Intermountain Risk Score with major adverse health events in patients positive for COVID-19: an observational evaluation of a US cohort by Horne, Benjamin D, Bledsoe, Joseph R, Muhlestein, Joseph B, May, Heidi T, Peltan, Ithan D, Webb, Brandon J, Carlquist, John F, Bennett, Sterling T, Rea, Susan, Bair, Tami L, Grissom, Colin K, Knight, Stacey, Ronnow, Brianna S, Le, Viet T, Stenehjem, Edward, Woller, Scott C, Knowlton, Kirk U, Anderson, Jeffrey L

“…ObjectivesThe Intermountain Risk Score (IMRS), composed using published sex-specific weightings of parameters in the complete blood count (CBC) and basic…”
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