Search Results - "KNOWLES, J"

ParEGO: a hybrid algorithm with on-line landscape approximation for expensive multiobjective optimization problems by Knowles, J.

“…This paper concerns multiobjective optimization in scenarios where each solution evaluation is financially and/or temporally expensive. We make use of nine…”
Get full text

Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials by Knowles, Tuomas P. J., Mezzenga, Raffaele

“…Proteinaceous materials based on the amyloid core structure have recently been discovered at the origin of biological functionality in a remarkably diverse set…”
Get full text

On the lag phase in amyloid fibril formation by Arosio, Paolo, Knowles, Tuomas P J, Linse, Sara

“…The formation of nanoscale amyloid fibrils from normally soluble peptides and proteins is a common form of self-assembly phenomenon that has fundamental…”
Get more information

A conceptual framework for integrated STEM education by Kelley, Todd R., Knowles, J. Geoff

“…The global urgency to improve STEM education may be driven by environmental and social impacts of the twenty-first century which in turn jeopardizes global…”
Get full text

Learning the molecular grammar of protein condensates from sequence determinants and embeddings by Saar, Kadi L., Morgunov, Alexey S., Qi, Runzhang, Arter, William E., Krainer, Georg, Lee, Alpha A., Knowles, Tuomas P. J.

“…Intracellular phase separation of proteins into biomolecular condensates is increasingly recognized as a process with a key role in cellular…”
Get full text

The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils by Thacker, Dev, Sanagavarapu, Kalyani, Frohm, Birgitta, Meisl, Georg, Knowles, Tuomas P. J., Linse, Sara

“…Crystals, nanoparticles, and fibrils catalyze the generation of new aggregates on their surface from the same type of monomeric building blocks as the parent…”
Get full text

Half a century of amyloids: past, present and future by Ke, Pu Chun, Zhou, Ruhong, Serpell, Louise C, Riek, Roland, Knowles, Tuomas P J, Lashuel, Hilal A, Gazit, Ehud, Hamley, Ian W, Davis, Thomas P, Fändrich, Marcus, Otzen, Daniel Erik, Chapman, Matthew R, Dobson, Christopher M, Eisenberg, David S, Mezzenga, Raffaele

“…Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for…”
Get more information

Fifty years of pulsar candidate selection: from simple filters to a new principled real-time classification approach by Lyon, R. J., Stappers, B. W., Cooper, S., Brooke, J. M., Knowles, J. D.

“…Improving survey specifications are causing an exponential rise in pulsar candidate numbers and data volumes. We study the candidate filters used to mitigate…”
Get full text

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy by Ruggeri, Francesco Simone, Mannini, Benedetta, Schmid, Roman, Vendruscolo, Michele, Knowles, Tuomas P. J.

“…The chemical and structural properties of biomolecules determine their interactions, and thus their functions, in a wide variety of biochemical processes…”
Get full text

Secondary nucleation in amyloid formation by Törnquist, Mattias, Michaels, Thomas C T, Sanagavarapu, Kalyani, Yang, Xiaoting, Meisl, Georg, Cohen, Samuel I A, Knowles, Tuomas P J, Linse, Sara

“…Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the same peptide or protein has emerged in the past two decades as a…”
Get more information

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide by Michaels, Thomas C. T., Šarić, Andela, Curk, Samo, Bernfur, Katja, Arosio, Paolo, Meisl, Georg, Dear, Alexander J., Cohen, Samuel I. A., Dobson, Christopher M., Vendruscolo, Michele, Linse, Sara, Knowles, Tuomas P. J.

“…Oligomeric species populated during the aggregation of the Aβ42 peptide have been identified as potent cytotoxins linked to Alzheimer’s disease, but the…”
Get full text

Nanomechanics of functional and pathological amyloid materials by Knowles, Tuomas P. J., Buehler, Markus J.

“…Amyloid materials are a class of fibrillar nanostructures that have been associated with neurodegenerative disorders such as Alzheimer's and Parkinson's…”
Get full text

Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation by Yuan, Chengqian, Levin, Aviad, Chen, Wei, Xing, Ruirui, Zou, Qianli, Herling, Therese W., Challa, Pavan Kumar, Knowles, Tuomas P. J., Yan, Xuehai

“…The transition of peptides and proteins from the solution phase into fibrillar structures is a general phenomenon encountered in functional and aberrant…”
Get full text

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions by Krainer, Georg, Welsh, Timothy J., Joseph, Jerelle A., Espinosa, Jorge R., Wittmann, Sina, de Csilléry, Ella, Sridhar, Akshay, Toprakcioglu, Zenon, Gudiškytė, Giedre, Czekalska, Magdalena A., Arter, William E., Guillén-Boixet, Jordina, Franzmann, Titus M., Qamar, Seema, George-Hyslop, Peter St, Hyman, Anthony A., Collepardo-Guevara, Rosana, Alberti, Simon, Knowles, Tuomas P. J.

“…Liquid–liquid phase separation of proteins underpins the formation of membraneless compartments in living cells. Elucidating the molecular driving forces…”
Get full text

Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation by Wen, Jitao, Hong, Liu, Krainer, Georg, Yao, Qiong-Qiong, Knowles, Tuomas P. J, Wu, Si, Perrett, Sarah

“…Liquid–liquid phase separation (LLPS) of proteins into biomolecular condensates has emerged as a fundamental principle underpinning cellular function and…”
Get full text

Molecular mechanisms of protein aggregation from global fitting of kinetic models by Meisl, Georg, Kirkegaard, Julius B, Arosio, Paolo, Michaels, Thomas C T, Vendruscolo, Michele, Dobson, Christopher M, Linse, Sara, Knowles, Tuomas P J

“…Understanding the mechanism of amyloid formation (protein aggregation) is important for developing treatments for many neurodegenerative diseases. Amylofit is…”
Get full text

ICTV Virus Taxonomy Profile: Picornaviridae by Zell, R, Delwart, E, Gorbalenya, A E, Hovi, T, King, A M Q, Knowles, N J, Lindberg, A M, Pallansch, M A, Palmenberg, A C, Reuter, G, Simmonds, P, Skern, T, Stanway, G, Yamashita, T, Ictv Report Consortium

“…The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera and >75 species. Most of the known…”
Get full text

An Evolutionary Approach to Multiobjective Clustering by Handl, J., Knowles, J.

“…The framework of multiobjective optimization is used to tackle the unsupervised learning problem, data clustering, following a formulation first proposed in…”
Get full text

Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films by Kamada, Ayaka, Rodriguez-Garcia, Marc, Ruggeri, Francesco Simone, Shen, Yi, Levin, Aviad, Knowles, Tuomas P. J.

“…The abundance of plant-derived proteins, as well as their biodegradability and low environmental impact make them attractive polymeric feedstocks for…”
Get full text

Digital image correlation in dental materials and related research: A review by Yoon, Sungsik, Jung, Hyung-Jo, Knowles, J.C., Lee, Hae-Hyoung

“…[Display omitted] Digital image correlation (DIC) is a non-contact image processing technique for full-field strain measurement. Although DIC has been widely…”
Get full text