Search Results - "KNOPF, Kevin"
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In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes
Published in Journal of the American Chemical Society (11-10-2017)“…Seven rhenium(I) complexes of the general formula fac-[Re(CO)3(NN)(OH2)]+ where NN = 2,2′-bipyridine (8), 4,4′-dimethyl-2,2′-bipyridine (9),…”
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An evaluation of reports of ciprofloxacin, levofloxacin, and moxifloxacin-association neuropsychiatric toxicities, long-term disability, and aortic aneurysms/dissections disseminated by the Food and Drug Administration and the European Medicines Agency
Published in Expert opinion on drug safety (02-11-2019)“…: Ciprofloxacin, levofloxacin, and moxifloxacin belong to the fluoroquinolone class of antibiotics and are amongst the most commonly prescribed antibiotics. In…”
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In Vivo Anticancer Activity of a Rhenium(I) Tricarbonyl Complex
Published in ACS medicinal chemistry letters (09-05-2019)“…The rhenium(I) complex fac-[Re(CO)3(2,9-dimethyl-1,10-phenanthroline)(OH2)]+ (1) was previously shown to exhibit potent in vitro anticancer activity in a…”
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Intention to probe into the colonoscopy trial: is it the procedure or the trial that failed?
Published in EClinicalMedicine (01-01-2023)Get full text
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End of an era of administering erythropoiesis stimulating agents among Veterans Administration cancer patients with chemotherapy-induced anemia
Published in PloS one (25-06-2020)“…Erythropoisis stimulating agent (ESA) use was addressed in Food and Drug Administration (FDA) Oncology Drug Advisory Committee (ODAC) meetings between 2004 and…”
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High Compliance With Choosing Wisely Breast Surgical Guidelines at a Safety-Net Hospital
Published in The Journal of surgical research (01-04-2022)“…Professional organizations recently set guidelines for avoiding surgeries of low utility and overutilization for the Choosing Wisely campaign. These include…”
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Factors delaying chemotherapy in patients with breast cancer at a safety-net hospital
Published in Journal of the National Medical Association (01-01-2022)“…Despite advances in healthcare and improved chemotherapy, disparities in breast cancer outcomes continue to persist. Our aim was to evaluate socioeconomic…”
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Caveat Medicus: Clinician experiences in publishing reports of serious oncology-associated adverse drug reactions
Published in PloS one (31-07-2019)“…Oncology-associated adverse drug/device reactions can be fatal. Some clinicians who treat single patients with severe oncology-associated toxicities have…”
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Health Equity Within Inequity: Timing of Diagnostic Breast Cancer Care in an Underserved Medical Population
Published in Anticancer research (01-07-2021)“…Background/Aim: We evaluated timeliness of care at a safety-net hospital after implementation of a multidisciplinary breast program. Patients and Methods: A…”
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Kilogram-Scale Preparation of an Aminopyrazole Building Block via Copper-Catalyzed Aryl Amidation
Published in Organic process research & development (16-04-2021)“…We describe a scalable method for preparing an aminopyrazole building block using copper-catalyzed amidation with acetamide as an ammonia surrogate. This…”
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End of an era for erythropoiesis‐stimulating agents in oncology
Published in International journal of cancer (15-05-2020)“…Erythropoiesis‐stimulating agents (ESAs) are available to treat chemotherapy‐induced anemia (CIA). In 2007–2008, regulatory notifications advised of venous…”
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Streamlined Synthesis of a Bicyclic Amine Moiety Using an Enzymatic Amidation and Identification of a Novel Solid Form
Published in Organic process research & development (18-06-2021)“…We describe a series of improvements to the synthesis of a 3,8-diazabicyclo[3.2.1]octane derivative that result in a reduced step count and higher overall…”
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Racial differences in treatment and survival in older patients with diffuse large B-cell lymphoma (DLBCL)
Published in BMC cancer (12-11-2010)“…Diffuse large B-cell lymphoma (DLBCL) comprises 31% of lymphomas in the United States. Although it is an aggressive type of lymphoma, 40% to 50% of patients…”
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The First 2 Years of Biosimilar Epoetin for Cancer and Chemotherapy‐Induced Anemia in the U.S.: A Review from the Southern Network on Adverse Reactions
Published in The oncologist (Dayton, Ohio) (01-08-2021)“…Biosimilars are biologic drug products that are highly similar to reference products in analytic features, pharmacokinetics and pharmacodynamics,…”
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Primary undifferentiated pleomorphic cardiac sarcoma presenting as right heart failure
Published in Radiology case reports (01-04-2021)“…Right-sided heart failure is a common sequela of left heart failure and seldom presents as a primary disorder. The differential diagnosis of right heart…”
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Live-cell phenotypic-biomarker microfluidic assay for the risk stratification of cancer patients via machine learning
Published in Nature biomedical engineering (01-10-2018)“…The risk stratification of prostate cancer and breast cancer tumours from patients relies on histopathology, selective genomic testing, or on other methods…”
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Meta-Analysis of the Efficacy and Safety of Bortezomib Re-Treatment in Patients With Multiple Myeloma
Published in Clinical lymphoma, myeloma and leukemia (01-10-2014)“…Micro-Abstract This meta-analysis of 23 studies of bortezomib-based retreatment in relapsed/refractory myeloma demonstrated a pooled, weighted average response…”
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The safety of bendamustine in patients with chronic lymphocytic leukemia or non-Hodgkin lymphoma and concomitant renal impairment: a retrospective electronic medical record database analysis
Published in Leukemia & lymphoma (01-06-2014)“…Abstract This retrospective study compared adverse-event rates in patients with chronic lymphocytic leukemia (CLL) or non-Hodgkin lymphoma (NHL), with and…”
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Economic Burden of Tyrosine Kinase Inhibitor Treatment Failure in Chronic Myeloid Leukemia
Published in Clinical lymphoma, myeloma and leukemia (01-11-2015)“…Micro-Abstract To understand the economic burden of tyrosine kinase inhibitor (TKI) treatment failure in chronic myeloid leukemia (CML), episodes of TKI…”
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Characteristics and treatment patterns among US patients with hairy cell leukemia: a retrospective claims analysis
Published in Journal of comparative effectiveness research (01-09-2017)“…Describe hairy cell leukemia (HCL) treatment patterns using a large, nationally representative US database. Adults newly diagnosed with HCL (1 January 2006 to…”
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