Search Results - "KNOBBE, Christiane B"

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression by Harris, Isaac S., Treloar, Aislinn E., Inoue, Satoshi, Sasaki, Masato, Gorrini, Chiara, Lee, Kim Chung, Yung, Ka Yi, Brenner, Dirk, Knobbe-Thomsen, Christiane B., Cox, Maureen A., Elia, Andrew, Berger, Thorsten, Cescon, David W., Adeoye, Adewunmi, Brüstle, Anne, Molyneux, Sam D., Mason, Jacqueline M., Li, Wanda Y., Yamamoto, Kazuo, Wakeham, Andrew, Berman, Hal K., Khokha, Rama, Done, Susan J., Kavanagh, Terrance J., Lam, Ching-Wan, Mak, Tak W.

“…Controversy over the role of antioxidants in cancer has persisted for decades. Here, we demonstrate that synthesis of the antioxidant glutathione (GSH), driven…”
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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function by Sasaki, Masato, Knobbe, Christiane B, Itsumi, Momoe, Elia, Andrew J, Harris, Isaac S, Chio, Iok In Christine, Cairns, Rob A, McCracken, Susan, Wakeham, Andrew, Haight, Jillian, Ten, Annick You, Snow, Bryan, Ueda, Takeshi, Inoue, Satoshi, Yamamoto, Kazuo, Ko, Myunggon, Rao, Anjana, Yen, Katharine E, Su, Shinsan M, Mak, Tak Wah

“…Isocitrate dehydrogenase-1 (IDH1) R132 mutations occur in glioma, but their physiological significance is unknown. Here we describe the generation and…”
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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics by Sasaki, Masato, Knobbe, Christiane B., Munger, Joshua C., Lind, Evan F., Brenner, Dirk, Brüstle, Anne, Harris, Isaac S., Holmes, Roxanne, Wakeham, Andrew, Haight, Jillian, You-Ten, Annick, Li, Wanda Y., Schalm, Stefanie, Su, Shinsan M., Virtanen, Carl, Reifenberger, Guido, Ohashi, Pamela S., Barber, Dwayne L., Figueroa, Maria E., Melnick, Ari, Zúñiga-Pflücker, Juan-Carlos, Mak, Tak W.

“…Mutations in isocitrate dehydrogenases IDH1 and IDH2 are common in human gliomas and acute myeloid leukaemias; here, mice that carry the IDH1(R132H) mutation…”
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Advances in the molecular genetics of gliomas — implications for classification and therapy by Reifenberger, Guido, Wirsching, Hans-Georg, Knobbe-Thomsen, Christiane B., Weller, Michael

“…Key Points The 2016 WHO Classification of Tumours of the Central Nervous System reflects a paradigm shift, replacing traditional histology-based glioma…”
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Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery by Wilson, Alicia S., Law, Hsei Di, Knobbe‐Thomsen, Christiane B., Kearney, Conor J., Oliaro, Jane, Binsfeld, Carole, Burgio, Gaetan, Starrs, Lora, Brenner, Dirk, Randall, Katrina L., Brüstle, Anne

“…Mutation of Dedicator of cytokinesis 8 (DOCK8) has previously been reported to provide resistance to the Th17 cell dependent EAE in mice. Contrary to…”
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2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation by Duncan, Gordon S., Brenner, Dirk, Tusche, Michael W., Brüstle, Anne, Knobbe, Christiane B., Elia, Andrew J., Mock, Thomas, Bray, Mark R., Krammer, Peter H., Mak, Tak W.

“…The endogenous metabolite of estradiol, 2-Methoxyestradiol (2ME2), is an antimitotic and antiangiogenic cancer drug candidate that also exhibits…”
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Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas by Knobbe, Christiane B, Reifenberger, Julia, Reifenberger, Guido

“…Aberrant activation of Ras signaling is a common finding in human glioblastomas. To determine the contribution of Ras gene mutations to this aberration, we…”
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A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites by Reich, Stefan, Nguyen, Chi D. L., Has, Canan, Steltgens, Sascha, Soni, Himanshu, Coman, Cristina, Freyberg, Moritz, Bichler, Anna, Seifert, Nicole, Conrad, Dominik, Knobbe-Thomsen, Christiane B., Tews, Björn, Toedt, Grischa, Ahrends, Robert, Medenbach, Jan

“…Stress response pathways are critical for cellular homeostasis, promoting survival through adaptive changes in gene expression and metabolism. They play key…”
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Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas by Reifenberger, Julia, Knobbe, Christiane B., Sterzinger, Astrid A., Blaschke, Britta, Schulte, Klaus W., Ruzicka, Thomas, Reifenberger, Guido

“…Ras signaling is important for the intracellular transduction of mitogenic stimuli from activated growth factor receptors. We have investigated 37 sporadic…”
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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation by Marquardt, Viktoria, Theruvath, Johanna, Pauck, David, Picard, Daniel, Qin, Nan, Blümel, Lena, Maue, Mara, Bartl, Jasmin, Ahmadov, Ulvi, Langini, Maike, Meyer, Frauke-Dorothee, Cole, Allison, Cruz-Cruz, Joselyn, Graef, Claus M, Wölfl, Matthias, Milde, Till, Witt, Olaf, Erdreich-Epstein, Anat, Leprivier, Gabriel, Kahlert, Ulf, Stefanski, Anja, Stühler, Kai, Keir, Stephen T, Bigner, Darell D, Hauer, Julia, Beez, Thomas, Knobbe-Thomsen, Christiane B, Fischer, Ute, Felsberg, Jörg, Hansen, Finn K, Vibhakar, Rajeev, Venkatraman, Sujatha, Cheshier, Samuel H, Reifenberger, Guido, Borkhardt, Arndt, Kurz, Thomas, Remke, Marc, Mitra, Siddhartha

“…While major advances have been made in improving the quality of life and survival of children with most forms of medulloblastoma (MB), those with MYC-driven…”
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Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target by Riemenschneider, Markus J., Knobbe, Christiane B., Reifenberger, Guido

“…We previously reported on the amplification and overexpression of the mouse double minute 4 homolog gene (MDM4) from 1q32 in a subset of malignant gliomas…”
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Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells by Brenner, Dirk, Brüstle, Anne, Lin, Gloria H. Y., Lang, Philipp A., Duncan, Gordon S., Knobbe-Thomsen, Christiane B., Paul, Michael St, Reardon, Colin, Tusche, Michael W., Snow, Bryan, Hamilton, Sara R., Pfefferle, Aline, Gilani, Syed O., Ohashi, Pamela S., Lang, Karl S., Mak, Tak W.

“…The ability to mount a strong immune response against pathogens is crucial for mammalian survival. However, excessive and uncontrolled immune reactions can…”
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Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC by Reifenberger, Julia, Knobbe, Christiane B., Wolter, Marietta, Blaschke, Britta, Schulte, Klaus W., Pietsch, Torsten, Ruzicka, Thomas, Reifenberger, Guido

“…Aberrant activation of the Wnt signaling pathway has been reported in different human tumor types, including malignant melanomas. We investigated 37 malignant…”
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The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells by Brüstle, Anne, Brenner, Dirk, Knobbe, Christiane B, Lang, Philipp A, Virtanen, Carl, Hershenfield, Brian M, Reardon, Colin, Lacher, Sonja M, Ruland, Jürgen, Ohashi, Pamela S, Mak, Tak W

“…Effector functions of inflammatory IL-17-producing Th (Th17) cells have been linked to autoimmune diseases such as experimental autoimmune encephalomyelitis…”
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Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas by Knobbe, Christiane B, Reifenberger, Guido

“…Glioblastomas frequently carry mutations in the PTEN tumor suppressor gene on 10q23.3. The tumor suppressor properties of Pten are closely related to its…”
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Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas by Sabha, Nesrin, Knobbe, Christiane B, Maganti, Majula, Al Omar, Soha, Bernstein, Mark, Cairns, Rob, Çako, Besmira, von Deimling, Andreas, Capper, David, Mak, Tak W, Kiehl, Tim-Rasmus, Carvalho, Philippe, Garrett, Evelyn, Perry, Arie, Zadeh, Gelareh, Guha, Abhijit, Sidney Croul

“…Grades II and III gliomas have unpredictable rates of progression, making management decisions difficult. Currently, several clinical and radiological…”
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Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real‐time reverse transcription‐polymerase chain reaction by van den Boom, Jörg, Wolter, Marietta, Blaschke, Britta, Knobbe, Christiane B., Reifenberger, Guido

“…To identify novel genes involved in glioma progression we performed suppression subtractive hybridization combined with cDNA array analysis on 4 patients with…”
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A Step Towards Optically Encoded Silver Release in 1D Photonic Crystals by Lotsch, Bettina V., Knobbe, Christiane B., Ozin, Geoffrey A.

“…The structural color of 1D photonic crystals modified with silver nanoparticles is a function of the silver‐loading state, which translates into an optically…”
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EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma by An, Zhenyi, Knobbe-Thomsen, Christiane B, Wan, Xiaohua, Fan, Qi Wen, Reifenberger, Guido, Weiss, William A

“…: Amplification of the gene and its truncation mutant are hallmarks of glioblastoma. Although coexpression of EGFR and EGFRvIII confers a growth advantage, how…”
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The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG by Prescher, Nina, Hänsch, Sebastian, Knobbe-Thomsen, Christiane B., Stühler, Kai, Poschmann, Gereon

“…The macrophage capping protein CAPG belongs to the gelsolin superfamily which modulates actin dynamics by capping the growing end of actin filaments in a Ca2+-…”
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