Search Results - "KNIGHT, Joy"

Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Both Global CD20 Gene and Protein Down-Regulation Regulated at the Pretranscriptional and Posttranscriptional Levels by CZUCZMAN, Myron S, OLEJNICZAK, Scott, GOWDA, Aruna, KOTOWSKI, Adam, BINDER, Arvinder, KAUR, Harman, KNIGHT, Joy, STAROSTIK, Petr, DEANS, Julie, HERNANDEZ-LLIZALITURRI, Francisco J

“…Acquirement of resistance to rituximab has been observed in lymphoma patients. To define mechanisms associated with rituximab resistance, we developed various…”
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Role of Polymorphic Human Cytochrome P450 Enzymes in Estrone Oxidation by CRIBB, Alastair E, KNIGHT, M. Joy, DRYER, Dagny, GUERNSEY, Judy, HENDER, Kimberly, TESCH, Marvin, SALEH, Tarek M

“…Estrogen and its metabolites are believed to play important roles in breast cancer. The influence of genetic polymorphisms in the enzymes responsible for…”
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Augmented Antitumor Activity against B-Cell Lymphoma by a Combination of Monoclonal Antibodies Targeting TRAIL-R1 and CD20 by MADDIPATLA, Sreeram, HERNANDEZ -ILIZALITURRI, Francisco J, KNIGHT, Joy, CZUCZMAN, Myron S

“…Purpose: Mapatumumab and lexatumumab are fully humanized, high-affinity immunoglobulin G 1λ monoclonal antibodies (mAb) that target/activate the tumor necrosis…”
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CYP17, catechol-o-methyltransferase, and glutathione transferase M1 genetic polymorphisms, lifestyle factors, and breast cancer risk in women on Prince Edward Island by Cribb, Alastair E, Joy Knight, Marion, Guernsey, Judy, Dryer, Dagny, Hender, Kimberly, Shawwa, Allam, Tesch, Marvin, Saleh, Tarek M

“…Genetic polymorphisms in enzymes controlling the formation and disposition of estrogens and their metabolites have been shown to influence breast cancer risk…”
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Perceived risk of breast cancer and god health locus of control in high risk African American and caucasian women by Nguyen, Minh-Tri, Thompson, Cheryl L., Knight, Joy

“…e24142 Background: African American women are more likely than any other racial groups to present with a later stage of breast cancer. Survival rates among…”
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Writing Histories of Law and Emotion by Bailey, Merridee L., Knight, Kimberley-Joy

“…In recent years the study of emotions in the past has received considerable attention. At the same time, many historians of law have shown reluctance to…”
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Immunomodulatory drugs stimulate natural killer‐cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti‐tumour activity of rituximab in vivo by Reddy, Nishitha, Hernandez‐Ilizaliturri, Francisco J., Deeb, George, Roth, Mark, Vaughn, Mary, Knight, Joy, Wallace, Paul, Czuczman, Myron S.

“…Summary The immunomodulatory drugs (IMiDs) lenalidomide and actimid (also known as CC‐4047) are thalidomide analogues which are more potent than their parental…”
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The findings and recommendations of a breast Multidisciplinary Genomic Tumor Board by Tsung, Karen, Thompson, Cheryl L., Knight, Joy, Maximuk, Steve, Sadri, Navid, Silverman, Paula

“…Abstract only…”
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Distinct cellular and therapeutic effects of obatoclax in rituximab‐sensitive and ‐resistant lymphomas by Brem, Elizabeth A., Thudium, Karen, Khubchandani, Sapna, Tsai, Ping‐Chiao, Olejniczak, Scott H., Bhat, Seema, Riaz, Wasif, Gu, Jenny, Iqbal, Arshad, Campagna, Ryan, Knight, Joy, Mavis, Cory, Hoskin, Paul, Deeb, George, Gibbs, John F., Fetterly, Gerald, Czuczman, Myron S., Hernandez‐Ilizaliturri, Francisco J.

“…Summary Bcl‐2 proteins represent a rheostat that controls cellular viability. Obatoclax, a BH3‐mimetic, has been designed to specifically target and counteract…”
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Methylseleninic Acid (MSA) Decreases DNA Synthesis, Induces Cell Death, and Sensitizes Both Rituximab Sensitive and Rituximab-Resistant Non-Hodgkin's Lymphoma Cell Lines to the Anti-Tumor Activity of Cisplatin and Gemcitabine by Hernandez-Ilizaliturri, Francisco J., Ali, Minhas, Knight, Joy, Rustum, Youcef M., Czuczman, Myron S.

“…Selenium (Se) is an essential trace element with antioxidant properties. Examination of the dietary intake of Se in more than 25 countries found an inverse…”
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Lenalidomide Enhances the Biological Activity of Galiximab Against Non-Hogkin's Lymphoma In Vitro and In Vivo by Reddy, Nishitha, Hernandez-Ilizaliturri, Francisco J., Knight, Joy, Myron, Czuczman S., (Intr. by Myron S. Czuczman)

“…Lenalidomide, a thalidomide analog, has dual anti-tumor activities against B-cell lymphomas and other hematological malignancies by inducing direct apoptosis…”
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Pegylated Granulocyte Colony Stimulating Factor (Peg-G-CSF) Enhances Mapatumumab-Mediated Antibody Dependent Cellular Cytotoxicity (ADCC) Against Non-Hodgkin's Lymphoma (NHL) Cell Lines Independent of NADPH Oxidase-Derived Reactive Oxidant Intermediates (ROIs) by Derby, Lyudmyla, Hernandez-Ilizaliturri, Francisco J., Segal, Brahm H., Knight, Joy, Bushey, Jennifer, Czuczman, Myron S.

“…ADCC is an important mechanism of action of rituximab and other monoclonal antibodies (mAb). In an attempt to improve the efficacy of rituximab while…”
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Targeting BH3-Domain Anti-Apoptotic Proteins with ABT-737 Decreases DNA Synthesis, Induces Cell Death and Sensitizes Rituximab-Sensitive and Rituximab-Resistant Non-Hodgkin's Lymphoma Cell Lines to the Anti-Tumor Activity of Chemotherapy Agents by Vinjamaram, Sanjay, Hernandez-Ilizaliturri, Francisco J., Retke, Steve, Knight, Joy, Czuczman, Myron S.

“…ABT-737 is a potent pan-bcl-2 inhibitor with known activity against chronic lymphocytic leukemia (CLL) cells and Mantle cell lymphoma (MCL) cell lines,…”
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GX15-070 and Bortezomib Induce Up-Regulation of BH3 Single Domain Pro-Apoptotic Proteins Puma and Noxa and Is Associated with Synergistic Anti-Tumor Activity in Rituximab-Sensitive, Rituximab-Resistant Cell Lines (RSCL and RRCL), and Primary Lymphoma Patient Specimens by Gruber, Elizabeth A., Czuczman, Myron S., Olejniczak, Scott H., Knight, Joy, Hernandez-Ilizaliturri, Francisco J.

“…The interactions between the members of the BH3 domain family of proteins play an important role in the development, progression, and prognosis in various…”
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Restoration of E-cadherin/β-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis by Lowy, Andrew M., Knight, Joy, Groden, Joanna

“…Background. β-Catenin is a component of the E-cadherin/catenin adhesion complex that maintains epithelial cell integrity. We have previously observed decreased…”
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CD52 over-expression affects rituximab-associated complement-mediated cytotoxicity but not antibody-dependent cellular cytotoxicity: Preclinical evidence that targeting CD52 with alemtuzumab may reverse acquired resistance to rituximab in non-Hodgkin lymphoma by Cruz, Raymond I., Hernandez-Ilizaliturri, Francisco J., Olejniczak, Scott, Deeb, George, Knight, Joy, Wallace, Paul, Thurberg, Beth L., Kennedy, William, Czuczman, Myron S.

“…In an attempt to define mechanisms by which B-cell non-Hodgkin lymphoma (NHL) may escape rituximab immunotherapy, we developed several rituximab-resistant cell…”
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Targeting BH3-Domain Anti-Apoptotic Proteins with GX15-070 Significantly Increases Rituximab-Mediated Antibody Dependent Cellular Cytotoxicity (ADCC) and Complement Mediated Cytotoxicity (CMC) Against B-Cell Lymphomas by Hernandez-Ilizaliturri, Francisco J., Bhat, Seema, Iqbal, Arshad, Olejniczak, Scott, Knight, Joy, Czuczman, Myron S.

“…There is a clinical need to develop innovative targeted therapies against B-cell lymphomas with both improved anti-tumor activity and more favorable toxicity…”
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Lenalidomide (Revlimid®) Enhances Monoclonal Antibody-Associated Anti-Tumor Activity Against Rituximab-Sensitive and Rituximab-Resistant B-Cell Lymphoma Cell Lines by Reddy, Nishitha, Cruz, Raymond, Hernandez-Ilizaliturri, Francisco, Knight, Joy, Czuczman, Myron S.

“…Background: Lenalidomide is a potent thalidomide analogue shown to activate both the innate and adoptive immune system, inhibit angiogenesis, and modify the…”
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Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma by Lowy, Andrew M, Fenoglio-Preiser, Cecilia, Kim, On Ja, Kordich, Jennifer, Gomez, Ana, Knight, Joy, James, Laura, Groden, Joanna

“…beta-Catenin functions as an integral part of the E-cadherin/catenin adhesion complex to maintain epithelial cell integrity. beta-Catenin also functions as…”
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Targeting BH3-Domain Anti-Apoptotic Proteins with GX15-070 Decreases DNA Synthesis, Induces Cell Death and Sensitizes Rituximab-Sensitive and Resistant Non-Hodgkin's Lymphoma Cell Lines to the Anti-Tumor Activity of Chemotherapy Agents by Hernandez-Ilizaliturri, Francisco J., Iqbal, Arshad, Alam, Naheed, Bhat, Seema, Olejniczak, Scott, Knight, Joy, Czuczman, Myron S.

“…GX15-070 is a potent pan-bcl-2 inhibitor with known activity against chronic lymphocytic leukemia (CLL) cells and mantle cell lymphoma (MCL) cell lines,…”
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