Search Results - "KNIGHT, GILLIAN E."

International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy by Abbracchio, Maria P, Burnstock, Geoffrey, Boeynaems, Jean-Marie, Barnard, Eric A, Boyer, José L, Kennedy, Charles, Knight, Gillian E, Fumagalli, Marta, Gachet, Christian, Jacobson, Kenneth A, Weisman, Gary A

“…There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of…”
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Hypoxia stimulates vesicular ATP release from rat osteoblasts by Orriss, Isabel R., Knight, Gillian E., Utting, Jennifer C., Taylor, Sarah E.B., Burnstock, Geoffrey, Arnett, Timothy R.

“…Many neuronal and non‐neuronal cell types release ATP in a controlled manner. After release, extracellular ATP (or, following hydrolysis, ADP) acts on cells in…”
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The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression by Burnstock, Geoffrey, Knight, Gillian E.

“…Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised. P2X7 receptors (P2X7R) are unusual in that there are extra amino acids…”
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P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP by Cockayne, Debra A., Dunn, Philip M., Zhong, Yu, Rong, Weifang, Hamilton, Sara G., Knight, Gillian E., Ruan, Huai‐Zhen, Ma, Bei, Yip, Ping, Nunn, Philip, McMahon, Stephen B., Burnstock, Geoffrey, Ford, Anthony P. D. W.

“…Extracellular ATP plays a role in nociceptive signalling and sensory regulation of visceral function through ionotropic receptors variably composed of P2X 2…”
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Cell culture: complications due to mechanical release of ATP and activation of purinoceptors by Burnstock, Geoffrey, Knight, Gillian E.

“…There is abundant evidence that ATP (adenosine 5′-triphosphate) is released from a variety of cultured cells in response to mechanical stimulation. The release…”
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Transient expression of thyrotropin releasing hormone peptide and mRNA in the rat hippocampus following global cerebral ischemia/reperfusion injury by Xiang, Zhenghua, Xu, Xiao-Hui, Knight, Gillian E., Burnstock, Geoffrey

“…The role of extra-hypothalamic thyrotropin-releasing hormone (TRH) has been investigated by pharmacological studies using TRH or its analogues and found to…”
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Purinergic Signaling in Healthy and Diseased Skin by Burnstock, Geoffrey, Knight, Gillian E., Greig, Aina V.H.

“…Adenosine 5′-triphosphate and adenosine receptors have been identified in adult and fetal keratinocytes, fibroblasts, melanocytes, mast cells, Langerhans…”
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Postnatal development of P2 receptors in the murine gastrointestinal tract by Giaroni, Cristina, Knight, Gillian E., Zanetti, Elena, Chiaravalli, Anna Maria, Lecchini, Sergio, Frigo, Gianmario, Burnstock, Geoffrey

“…The actions of purine and pyrimidine compounds on isolated segments of the mouse intestine were investigated during postnatal development. The localization of…”
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Inhibition of P2X7 receptors improves outcomes after traumatic brain injury in rats by Liu, Xiaofeng, Zhao, Zhengqing, Ji, Ruihua, Zhu, Jiao, Sui, Qian-Qian, Knight, Gillian E., Burnstock, Geoffrey, He, Cheng, Yuan, Hongbin, Xiang, Zhenghua

“…Traumatic brain injury (TBI) is the leading cause of death and disability for people under the age of 45 years worldwide. Neuropathology after TBI is the…”
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Alterations in purinergic and cholinergic components of contractile responses of isolated detrusor contraction in a rat model of partial bladder outlet obstruction by BANKS, FREDERICK C.L., KNIGHT, GILLIAN E., CALVERT, ROBERT C., MORGAN, ROBERT J., BURNSTOCK, GEOFFREY

“…OBJECTIVE To study the effect of 3 weeks of partial bladder outlet obstruction (BOO), compared to a sham operation, on the cholinergic and purinergic…”
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Smooth Muscle and Purinergic Contraction of the Human, Rabbit, Rat, and Mouse Testicular Capsule by Banks, Frederick C.L, Knight, Gillian E, Calvert, Robert C, Turmaine, Mark, Thompson, Cecil S, Mikhailidis, Dimitri P, Morgan, Robert J, Burnstock, Geoffrey

“…The smooth-muscle cells of the testicular capsule (tunica albuginea) of man, rat, and mouse were examined by electron microscopy. They were characteristically…”
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Expression of P2X receptors in the rat anterior pituitary by Zhao, Wenqi, Zhang, Yu, Ji, Ruihua, Knight, Gillian E., Burnstock, Geoffrey, Yuan, Hongbin, Xiang, Zhenghua

“…In this study, the distribution patterns of P2X1 to P2X7 receptors in the anterior pituitary cells of rat were studied with single-, double-, and…”
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A subpopulation of gonadotropin-releasing hormone neurons in the adult mouse forebrain is [gamma]-Aminobutyric acidergic by Zhu, Jiao, Xu, Xiao-hui, Knight, Gillian E, He, Cheng, Burnstock, Geoffrey, Xiang, Zhenghua

“…Gonadotropin-releasing hormone (GnRH) neurons play a pivotal role in reproductive function. GnRH is released in distinct pulses that are regulated by…”
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Purine‐ and pyrimidine‐induced responses and P2Y receptor characterization in the hamster proximal urethra by Pinna, Christian, Glass, Rainer, Knight, Gillian E, Bolego, Chiara, Puglisi, Lina, Burnstock, Geoffrey

“…1 Purine and pyrimidine compounds were investigated on hamster proximal urethral circular smooth muscle preparations. In situ hybridization studies were…”
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A subpopulation of gonadotropin-releasing hormone neurons in the adult mouse forebrain is γ-Aminobutyric acidergic by Zhu, Jiao, Xu, Xiao-hui, Knight, Gillian E., He, Cheng, Burnstock, Geoffrey, Xiang, Zhenghua

“…Gonadotropin‐releasing hormone (GnRH) neurons play a pivotal role in reproductive function. GnRH is released in distinct pulses that are regulated by…”
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Expression of P2X1 receptors in somatostatin-containing cells in mouse gastrointestinal tract and pancreatic islets of both mouse and human by Ji, Ruihua, Zhu, Jiao, Wang, Dan, Sui, Qian-Qian, Knight, Gillian E., Burnstock, Geoffrey, Yuan, Hongbin, Xiang, Zhenghua

“…With immunohistochemical and Western blot techniques, P2X1 receptors were detected in the whole mouse gastrointestinal tract and pancreatic islets of mouse and…”
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A modified protocol for the detection of three different mRNAs with a new-generation in situ hybridization chain reaction on frozen sections by Sui, Qian-qian, Zhu, Jiao, Li, Xiangnan, Knight, Gillian E., He, Cheng, Burnstock, Geoffrey, Yuan, Hongbin, Xiang, Zhenghua

“…A new multiple fluorescence in situ hybridization method based on hybridization chain reaction was recently reported, enabling simultaneous mapping of multiple…”
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Osteoblast responses to nucleotides increase during differentiation by Orriss, Isabel R., Knight, Gillian E., Ranasinghe, Sam, Burnstock, Geoffrey, Arnett, Timothy R.

“…Accumulating evidence suggests that extracellular nucleotides, signaling through P2 receptors, play a role in modulating bone cell function. ATP and ADP…”
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Smooth Muscle and Purinergic Contraction of the Human, Rabbit, Rat, and Mouse Testicular Capsule1 by Banks, Frederick C. L, Knight, Gillian E, Calvert, Robert C, Turmaine, Mark, Thompson, Cecil S, Mikhailidis, Dimitri P, Morgan, Robert J, Burnstock, Geoffrey

“…The smooth-muscle cells of the testicular capsule (tunica albuginea) of man, rat, and mouse were examined by electron microscopy. They were characteristically…”
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Electroconvulsive therapy: a novel hypothesis for the involvement of purinergic signalling by Sadek, Ahmed-Ramadan, Knight, Gillian E., Burnstock, Geoffrey

“…It is proposed that ATP is released from both neurons and glia during electroconvulsive therapy (ECT) and that this leads to reduction of depressive behaviour…”
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