Search Results - "KNEPEL, WILLHART"

A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: Reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice by Böer, Ulrike, Noll, Christine, Cierny, Irmgard, Krause, Doris, Hiemke, Christoph, Knepel, Willhart

“…The transcription factor CREB regulates adaptive responses like memory consolidation, addiction, and synaptic refinement. Recently, chronic psychosocial stress…”
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CRE/CREB-driven up-regulation of gene expression by chronic social stress in CRE-luciferase transgenic mice: reversal by antidepressant treatment by Böer, Ulrike, Alejel, Tahseen, Beimesche, Stephan, Cierny, Irmgard, Krause, Doris, Knepel, Willhart, Flügge, Gabriele

“…It has been suggested that stress provokes neuropathological changes and may thus contribute to the precipitation of affective disorders such as depression…”
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Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice by Oetjen, Elke, Baun, Diana, Beimesche, Stephan, Krause, Doris, Cierny, Irmgard, Blume, Roland, Dickel, Corinna, Wehner, Simone, Knepel, Willhart

“…Cyclosporin A and tacrolimus are clinically important immunosuppressive drugs. They share a diabetogenic action as one of their most serious adverse effects…”
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Protein Kinase B Activity Is Sufficient to Mimic the Effect of Insulin on Glucagon Gene Transcription by Schinner, Sven, Barthel, Andreas, Dellas, Claudia, Grzeskowiak, Rafal, Sharma, Sanjeev K., Oetjen, Elke, Blume, Roland, Knepel, Willhart

“…Insulin inhibits glucagon gene transcription, and insulin deficiency is associated with hyperglucagonemia that contributes to hyperglycemia in diabetes…”
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Insulin Responsiveness of the Glucagon Gene Conferred by Interactions between Proximal Promoter and More Distal Enhancer-like Elements Involving the Paired-domain Transcription Factor Pax6 by Grzeskowiak, Rafal, Amin, Jasmin, Oetjen, Elke, Knepel, Willhart

“…Regulation of gene transcription is an important aspect of insulin's action. However, the mechanisms involved are poorly understood. Insulin inhibits glucagon…”
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Gene-specific Transcriptional Activity of the Insulin cAMP-responsive Element Is Conferred by NF-Y in Combination with cAMP Response Element-binding Protein by Eggers, A, Siemann, G, Blume, R, Knepel, W

“…Cyclic AMP stimulates insulin gene transcription through a cAMP response element (CRE). In the present study the insulin CRE-binding proteins and their…”
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Characterization of a Novel Calcium Response Element in the Glucagon Gene by Fürstenau, U, Schwaninger, M, Blume, R, Jendrusch, E M, Knepel, W

“…To maintain blood glucose levels within narrow limits, the synthesis and secretion of pancreatic islet hormones is controlled by a variety of extracellular…”
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Inhibition of cyclic AMP response element-binding protein/cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context by Siemann, G, Blume, R, Grapentin, D, Oetjen, E, Schwaninger, M, Knepel, W

“…The immunosuppressants cyclosporin A and FK506 (tacrolimus) can block the phosphatase calcineurin, thereby inhibiting gene transcription directed by the cyclic…”
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Heterodimeric Pbx-Prep1 Homeodomain Protein Binding to the Glucagon Gene Restricting Transcription in a Cell Type-dependent Manner by Herzig, S, Fuzesi, L, Knepel, W

“…Homeodomain proteins specify developmental pathways and cell-specific gene transcription whereby proteins of the PBC subclass can direct target gene…”
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Enhancement by lithium of cAMP-induced CRE/CREB-directed gene transcription conferred by TORC on the CREB basic leucine zipper domain by Böer, Ulrike, Eglins, Julia, Krause, Doris, Schnell, Susanne, Schöfl, Christof, Knepel, Willhart

“…The molecular mechanism of the action of lithium salts in the treatment of bipolar disorder is not well understood. As their therapeutic action requires…”
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Chronic Lithium Salt Treatment Reduces CRE CREB-Directed Gene Transcription and Reverses Its Upregulation by Chronic Psychosocial Stress in Transgenic Reporter Gene Mice by BÖER, Ulrike, CIERNY, Irmgard, KRAUSE, Doris, HEINRICH, Annette, HONGYIN LIN, MAYR, Georg, HIEMKE, Christoph, KNEPEL, Willhart

“…The molecular mechanism of action of the mood stabilizer lithium is assumed to involve changes in gene expression leading to neuronal adaptation. The…”
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Effect of transection of subfornical organ efferent projections on vasopressin release induced by angiotensin or isoprenaline in the rat by Knepel, W, Nutto, D, Meyer, D K

“…Transection of subfornical organ efferents in the rat prevented the vasopressin release in response to intravenous angiotensin II infusion or following a small…”
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Activation of the dual-leucine-zipper-bearing kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A by Plaumann, Silke, Blume, Roland, Börchers, Svenja, Steinfelder, Hans Jürgen, Knepel, Willhart, Oetjen, Elke

“…Post-transplant diabetes is an untoward effect often observed under immunosuppressive therapy with cyclosporin A. Besides the development of peripheral insulin…”
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The homeodomain of PAX6 is essential for PAX6-dependent activation of the rat glucagon gene promoter: Evidence for a PH0-like binding that induces an active conformation by Grapp, Marcel, Teichler, Sabine, Kitz, Julia, Dibaj, Payam, Dickel, Corinna, Knepel, Willhart, Krätzner, Ralph

“…The transcription factor PAX6 plays an important role in transcriptional regulation of the peptide hormone glucagon from pancreatic α-cells. PAX6 contains two…”
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Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC by Heinrich, Annette, Böer, Ulrike, Tzvetkov, Mladen, Oetjen, Elke, Knepel, Willhart

“…Lithium salts are clinically important drugs used to treat bipolar mood disorder. The mechanisms accounting for the clinical efficacy are not completely…”
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A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription by Krätzner, Ralph, Fröhlich, Florian, Lepler, Katrin, Schröder, Michaela, Röher, Katharina, Dickel, Corinna, Tzvetkov, Mladen V, Quentin, Thomas, Oetjen, Elke, Knepel, Willhart

“…The peptide hormone glucagon stimulates hepatic glucose output, and its levels in the blood are elevated in type 2 diabetes mellitus. The nuclear receptor…”
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Synthesis of Formacetal-Linked Dinucleotides to Facilitate dsDNA Bending and Binding to the Homeodomain of Pax6 by Pitulescu, Marian, Grapp, Marcel, Krätzner, Ralph, Knepel, Willhart, Diederichsen, Ulf

“…Two formacetal‐linked dinucleotides TT and TA were synthesized as phosphoramidite building blocks for solid‐phase synthesis. Incorporated in a 29‐mer DNA, the…”
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The immunosuppressive drugs cyclosporin A and tacrolimus inhibit membrane depolarization‐induced CREB transcriptional activity at the coactivator level by Oetjen, Elke, Thoms, Kai‐Martin, Laufer, Yvonne, Pape, Daniela, Blume, Roland, Li, Pingfeng, Knepel, Willhart

“…1 Cyclosporin A and tacrolimus are clinically important immunosuppressive drugs directly targeting the transcription factor nuclear factor of activated T cells…”
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Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans by Sharma, Sanjeev K, Leinemann, Ulrike, Ratke, Regine, Oetjen, Elke, Blume, Roland, Dickel, Corinna, Knepel, Willhart

“…The pancreatic islet hormone glucagon stimulates hepatic glucose production and thus maintains blood glucose levels in the fasting state. Transcription factors…”
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Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB by Oetjen, Elke, Grapentin, Daniela, Blume, Roland, Seeger, Michael, Krause, Doris, Eggers, Anke, Knepel, Willhart

“…Cyclosporin A and tacrolimus are important immunosuppressive drugs. They share a diabetogenic action as one of their most serious adverse effects. In a single…”
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