Search Results - "KNAUB, LESLIE"

Mitochondrial respiration is lower in the intrauterine growth‐restricted fetal sheep heart by Chang, Eileen I., Stremming, Jane, Knaub, Leslie A., Wesolowski, Stephanie R., Rozance, Paul J., Sucharov, Carmen C., Reusch, Jane E. B., Brown, Laura D.

“…Fetuses affected by intrauterine growth restriction have an increased risk of developing heart disease and failure in adulthood. Compared with controls, late…”
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Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth-restricted fetal sheep by Stremming, Jane, Chang, Eileen I, Knaub, Leslie A, Armstrong, Michael L, Baker, 2nd, Peter R, Wesolowski, Stephanie R, Reisdorph, Nichole, Reusch, Jane E B, Brown, Laura D

“…Skeletal muscle from the late gestation sheep fetus with intrauterine growth restriction (IUGR) has evidence of reduced oxidative metabolism. Using a sheep…”
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Nitric oxide regulates vascular adaptive mitochondrial dynamics by Miller, Matthew W, Knaub, Leslie A, Olivera-Fragoso, Luis F, Keller, Amy C, Balasubramaniam, Vivek, Watson, Peter A, Reusch, Jane E B

“…Cardiovascular disease risk factors, such as diabetes, hypertension, dyslipidemia, obesity, and physical inactivity, are all correlated with impaired…”
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Single‐leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes by Scalzo, Rebecca L., Schauer, Irene E., Rafferty, Deirdre, Knaub, Leslie A., Kvaratskhelia, Nina, Johnson, Taro Kaelix, Pott, Gregory B., Abushamat, Layla A., Whipple, Mary O., Huebschmann, Amy G., Cree‐Green, Melanie, Reusch, Jane E. B., Regensteiner, Judith G.

“…Key points People with type 2 diabetes (T2D) have impaired skeletal muscle oxidative flux due to limited oxygen delivery. In the current study, this impairment…”
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Sex Differences in the Skeletal Muscle Response to a High Fat, High Sucrose Diet in Rats by Hulett, Nicholas A, Knaub, Leslie A, Hull, Sara E, Pott, Gregory B, Peelor, Rick, Miller, Benjamin F, Shankar, Kartik, Rudolph, Michael C, Reusch, Jane E B, Scalzo, Rebecca L

“…Men are diagnosed with type 2 diabetes at lower body mass indexes than women; the role of skeletal muscle in this sex difference is poorly understood. Type 2…”
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Breast Cancer Endocrine Therapy Promotes Weight Gain With Distinct Adipose Tissue Effects in Lean and Obese Female Mice by Scalzo, Rebecca L, Foright, Rebecca M, Hull, Sara E, Knaub, Leslie A, Johnson-Murguia, Stevi, Kinanee, Fotobari, Kaplan, Jeffrey, Houck, Julie A, Johnson, Ginger, Sharp, Rachel R, Gillen, Austin E, Jones, Kenneth L, Zhang, Anni M Y, Johnson, James D, MacLean, Paul S, Reusch, Jane E B, Wright-Hobart, Sabrina, Wellberg, Elizabeth A

“…Breast cancer survivors treated with tamoxifen and aromatase inhibitors report weight gain and have an elevated risk of type 2 diabetes, especially if they…”
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(-)-Epicatechin Improves Vasoreactivity and Mitochondrial Respiration in Thermoneutral-Housed Wistar Rat Vasculature by Chun, Ji Hye, Henckel, Melissa M, Knaub, Leslie A, Hull, Sara E, Pott, Greg B, Walker, Lori A, Reusch, Jane E-B, Keller, Amy C

“…Cardiovascular disease (CVD) is a global health concern. Vascular dysfunction is an aspect of CVD, and novel treatments targeting vascular physiology are…”
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(-)-Epicatechin Reverses Glucose Intolerance in Rats Housed at Thermoneutrality by Chun, Ji Hye, Henckel, Melissa M, Knaub, Leslie A, Hull, Sara E, Pott, Greg B, Ramirez, David G, Reusch, Jane E-B, Keller, Amy C

“…Diabetes is a life-threatening and debilitating disease with pathological hallmarks, including glucose intolerance and insulin resistance. Plant compounds are…”
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Muscle mitochondrial function is impaired in adults with type 1 diabetes by Gottlieb, Daniel, Abushamat, Layla A., Nadeau, Kristen J., Regensteiner, Judith G., Reusch, Jane E.B., Tommerdahl, Kalie L., Rice, John, Knaub, Leslie A., Monaco, Cynthia M.F., Hawke, Thomas J., Perry, Christopher G.R., Cree, Melanie G., Schauer, Irene E.

“…Type 1 diabetes has been associated with mitochondrial dysfunction. However, the mechanism of this dysfunction in adults remains unclear. A secondary analysis…”
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Saxagliptin Restores Vascular Mitochondrial Exercise Response in the Goto-Kakizaki Rat by Keller, Amy C, Knaub, Leslie A, Miller, Matthew W, Birdsey, Nicholas, Klemm, Dwight J, Reusch, Jane E B

“…Cardiovascular disease risk and all-cause mortality are largely predicted by physical fitness. Exercise stimulates vascular mitochondrial biogenesis through…”
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(–)-Epicatechin Modulates Mitochondrial Redox in Vascular Cell Models of Oxidative Stress by Reusch, Jane E. B., Nozik-Grayck, Eva, Chun, Ji Hye, Knaub, Leslie A., Johnston, Aspen, Elajaili, Hanan, Hull, Sara E., Keller, Amy C., Walker, Lori

“…Diabetes mellitus affects 451 million people worldwide, and people with diabetes are 3-5 times more likely to develop cardiovascular disease. In vascular…”
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Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues by Wang, Hong, Knaub, Leslie A, Jensen, Dalan R, Young Jung, Dae, Hong, Eun-Gyoung, Ko, Hwi-Jin, Coates, Alison M, Goldberg, Ira J, de la Houssaye, Becky A, Janssen, Rachel C, McCurdy, Carrie E, Rahman, Shaikh M, Soo Choi, Cheol, Shulman, Gerald I, Kim, Jason K, Friedman, Jacob E, Eckel, Robert H

“…Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues…”
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CREB Downregulation in Vascular Disease: A Common Response to Cardiovascular Risk by Schauer, Irene E, Knaub, Leslie A, Lloyd, Monique, Watson, Peter A, Gliwa, Catherine, Lewis, Katherine E, Chait, Alan, Klemm, Dwight J, Gunter, Jody M, Bouchard, Ron, McDonald, Thomas O, OʼBrien, Kevin D, Reusch, Jane E.B

“…OBJECTIVE—To examine the impact of low-density lipoprotein (LDL), an established mediator of atherosclerosis, on the transcription factor cAMP-response…”
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Fully automated software for quantitative measurements of mitochondrial morphology by McClatchey, P Mason, Keller, Amy C, Bouchard, Ron, Knaub, Leslie A, Reusch, Jane E B

“…Mitochondria undergo dynamic changes in morphology in order to adapt to changes in nutrient and oxygen availability, communicate with the nucleus, and modulate…”
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Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice by Watson, Peter A, Birdsey, Nicholas, Huggins, Gordon S, Svensson, Eric, Heppe, Daniel, Knaub, Leslie

“…Cardiac failure is associated with diminished activation of the transcription factor cyclic nucleotide regulatory element binding-protein (CREB), and…”
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Targeting mitochondria to restore failed adaptation to exercise in diabetes by Geary, Kate, Knaub, Leslie A, Schauer, Irene E, Keller, Amy C, Watson, Peter A, Miller, Matthew W, Garat, Chrystelle V, Nadeau, Kristen J, Cree-Green, Melanie, Pugazhenthi, Subbiah, Regensteiner, Judith G, Klemm, Dwight J, Reusch, Jane E B

“…Our translational research group focuses on addressing the problem of exercise defects in diabetes with basic research efforts in cell and rodent models and…”
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Glucagon‐like peptide‐1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats by Scalzo, Rebecca L., Knaub, Leslie A., Hull, Sara E., Keller, Amy C., Hunter, Kendall, Walker, Lori A., Reusch, Jane E. B.

“…Cardiorespiratory fitness (CRF) inversely predicts cardiovascular (CV) mortality and CRF is impaired in people with type 2 diabetes (T2D). Aerobic exercise…”
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Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model by Reusch, Jane E. B., Klemm, Dwight J., Geary, Kate E., Miller, Matthew W., Bouchard, Ron, Connon, Chelsea A., McClatchey, P. Mason, Knaub, Leslie A., Keller, Amy C., Walker, Lori A.

“…Diabetes affects more than 330 million people worldwide and causes elevated cardiovascular disease risk. Mitochondria are critical for vascular function,…”
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Impaired response to exercise intervention in the vasculature in metabolic syndrome by Knaub, Leslie A, McCune, Sylvia, Chicco, Adam J, Miller, Matthew, Moore, Russell L, Birdsey, Nicholas, Lloyd, Monique I, Villarreal, Juan, Keller, Amy C, Watson, Peter A, Reusch, Jane E B

“…Physical activity decreases risk for diabetes and cardiovascular disease morbidity and mortality; however, the specific impact of exercise on the diabetic…”
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Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype? by Jensen, Dalan R., Knaub, Leslie A., Konhilas, John P., Leinwand, Leslie A., MacLean, Paul S., Eckel, Robert H.

“…LPL is an enzyme involved in the breakdown and uptake of lipoprotein triglycerides. In the present study, we examined how the transgenic (Tg) overexpression of…”
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