Search Results - "KNÄUPER, Vera"

P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2 by Adamczyk, Magdalena, Griffiths, Rhiannon, Dewitt, Sharon, Knäuper, Vera, Aeschlimann, Daniel

“…Transglutaminases (denoted TG or TGM) are externalized from cells via an unknown unconventional secretory pathway. Here, we show for the first time that…”
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Mesenchymal Transglutaminase 2 Activates Epithelial ADAM17: Link to G-Protein-Coupled Receptor 56 (ADGRG1) Signalling by Bauer, Lea, Edwards, Jessica, Heil, Andreas, Dewitt, Sharon, Biebermann, Heike, Aeschlimann, Daniel, Knäuper, Vera

“…A wound healing model was developed to elucidate the role of mesenchymal-matrix-associated transglutaminase 2 (TG2) in keratinocyte re-epithelialisation. TG2…”
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Multi-Omics Analysis of Glioblastoma and Glioblastoma Cell Line: Molecular Insights Into the Functional Role of GPR56 and TG2 in Mesenchymal Transition by Ganesh, Raksha A, Sonpatki, Pranali, Naik, Divya, John, Arivusudar Everad, Sathe, Gajanan, Lakshmikantha, Akhila, Chandrachari, Komal Prasad, Bauer, Lea, Knäuper, Vera, Aeschlimann, Daniel, Venkatraaman, Krishnan, Shah, Nameeta, Sirdeshmukh, Ravi

“…G protein-coupled receptor 56 (GPR56/ADGRG1) is an adhesion GPCR with an essential role in brain development and cancer. Elevated expression of GPR56 was…”
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The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3 by Amour, Augustin, Knight, C.Graham, Webster, Ailsa, Slocombe, Patrick M., Stephens, Paul E., Knäuper, Vera, Docherty, Andrew J.P., Murphy, Gillian

“…A recombinant soluble form of the catalytic domain of human ADAM-10 was expressed as an Fc fusion protein from myeloma cells. The ADAM-10 was catalytically…”
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Relating matrix metalloproteinase structure to function: Why the “hemopexin” domain? by Murphy, Gillian, Knäuper, Vera

“…Matrix metalloproteinases are thought to be key players in the remodelling activity of cells associated with both physiological and pathological processes…”
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Biochemical Characterization of Human Collagenase-3 (∗) by Knäuper, Vera, López-Otin, Carlos, Smith, Bryan, Knight, Graham, Murphy, Gillian

“…The cDNA of a novel matrix metalloproteinase, collagenase-3 (MMP-13) has been isolated from a breast tumor library (Freije, J. M. P., Diez-Itza, I., Balbin,…”
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Mechanisms for pro matrix metalloproteinase activation by MURPHY, GILLIAN, STANTON, HEATHER, COWELL, SUSAN, BUTLER, GEORGINA, KNÄUPER, VERA, ATKINSON, SUSAN, GAVRILOVIC, JELENA

“…The activation of pro matrix metalloproteinases (MMPs) by sequential proteolysis of the propeptide blocking the active site cleft is regarded as one of the key…”
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Identification and Enzymatic Characterization of Two Diverging Murine Counterparts of Human Interstitial Collagenase (MMP-1) Expressed at Sites of Embryo Implantation by Balbı́n, Milagros, Fueyo, Antonio, Knäuper, Vera, López, José M., Álvarez, Jesús, Sánchez, Luis M., Quesada, Vı́ctor, Bordallo, Javier, Murphy, Gillian, López-Otı́n, Carlos

“…Remodeling of fibrillar collagen in mouse tissues has been widely attributed to the activity of collagenase-3 (matrix metalloproteinase-13 (MMP-13)), the main…”
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Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13 by Knäuper, Vera, Bailey, Louise, Worley, Joanna R, Soloway, Paul, Patterson, Margaret L, Murphy, Gillian

“…Procollagenase-3 (proMMP-13) can be activated by soluble or cell associated membrane type matrix metalloproteinase 1 (MT1-MMP). In this study we show that the…”
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The Role of the C-terminal Domain of Human Collagenase-3 (MMP-13) in the Activation of Procollagenase-3, Substrate Specificity, and Tissue Inhibitor of Metalloproteinase Interaction by Knäuper, Vera, Cowell, Susan, Smith, Bryan, López-Otin, Carlos, O'Shea, Mark, Morris, Helen, Zardi, Luciano, Murphy, Gillian

“…Recombinant human procollagenase-3 and a C-terminal truncated form (Δ249-451 procollagenase-3) have been stably expressed in myeloma cells and purified. The…”
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Degradation of cartilage aggrecan by collagenase-3 (MMP-13) by Fosang, Amanda J., Last, Karena, Knäuper, Vera, Murphy, Gillian, Neame, Peter J.

“…Degradation of the large cartilage proteoglycan aggrecan in arthritis involves an unidentified enzyme aggrecanase, and at least one of the matrix…”
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Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in Other Family Members by Velasco, G, Pendás, A M, Fueyo, A, Knäuper, V, Murphy, G, López-Otín, C

“…A cDNA encoding a new human matrix metalloproteinase (MMP), tentatively called MMP-23, has been cloned from an ovary cDNA library. This protein exhibits…”
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ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells by Mattern, Jens, Roghi, Christian S., Hurtz, Melanie, Knäuper, Vera, Edwards, Dylan R., Poghosyan, Zaruhi

“…A Disintegrin and Metalloproteinase-15 (ADAM15) is a transmembrane protein involved in protein ectodomain shedding, cell adhesion and signalling. We previously…”
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P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis? by Aeschlimann, Daniel, Knäuper, Vera

“…Transglutaminases have important roles in stabilizing extracellular protein assemblies in tissue repair processes but some reaction products can stimulate…”
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Identification and Structural and Functional Characterization of Human Enamelysin (MMP-20) by Llano, Elena, Pendás, Alberto M., Knäuper, Vera, Sorsa, Timo, Salo, Tuula, Salido, Eduardo, Murphy, Gillian, Simmer, James P., Bartlett, John D., López-Otín, Carlos

“…A cDNA encoding a new human matrix metalloproteinase (MMP) has been cloned from RNA prepared from odontoblastic cells. The open reading frame of the cloned…”
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Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP) by Worley, Joanna R, Thompkins, Philip B, Lee, Meng H, Hutton, Mike, Soloway, Paul, Edwards, Dylan R, Murphy, Gillian, Knäuper, Vera

“…Fundamental cellular processes including angiogenesis and cell migration require a proteolytic cascade driven by interactions of membrane-type matrix…”
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Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells by Stringa, E, Knäuper, V, Murphy, G, Gavrilovic, J

“…Cell migration is a key event in many biological processes and depends on signals from both extracellular matrix and soluble motogenic factors. During…”
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Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25) by English, William Roger, Velasco, Gloria, Stracke, Jan Olaf, Knäuper, Vera, Murphy, Gillian

“…This study describes the biochemical characterisation of the catalytic domain of membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP25, leukolysin). Its…”
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Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3 by Cowell, S, Knäuper, V, Stewart, M L, D'Ortho, M P, Stanton, H, Hembry, R M, López-Otín, C, Reynolds, J J, Murphy, G

“…SW1353 chondrosarcoma cells cultured in the presence of interleukin-1, concanavalin A or PMA secreted procollagenase 3 (matrix metalloproteinase-13). The…”
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Limited Cleavage of Extracellular Matrix Protein BM-40 by Matrix Metalloproteinases Increases Its Affinity for Collagens by Sasaki, Takako, Göhring, Walter, Mann, Karlheinz, Maurer, Patrik, Hohenester, Erhard, Knäuper, Vera, Murphy, Gillian, Timpl, Rupert

“…The 33-kDa matrix protein BM-40 (SPARC, osteonectin) consists of an acidic N-terminal domain I, a central cysteine-rich follistatin-like module, and a…”
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