Search Results - "KLUSSMANN, S"

Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes by Sayyed, S. G., Hägele, H., Kulkarni, O. P., Endlich, K., Segerer, S., Eulberg, D., Klussmann, S., Anders, H.-J.

“…Aims/hypothesis Chemokine (C-X-C motif) ligand 12 (CXCL12) (also known as stromal cell-derived factor-1 [SDF-1]-alpha) is a homeostatic chemokine with multiple…”
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Hematopoietic Stem and Progenitor Cell Mobilization in Mice and Humans by a First-in-Class Mirror-Image Oligonucleotide Inhibitor of CXCL12 by Vater, A, Sahlmann, J, Kröger, N, Zöllner, S, Lioznov, M, Maasch, C, Buchner, K, Vossmeyer, D, Schwoebel, F, Purschke, W G, Vonhoff, S, Kruschinski, A, Hübel, K, Humphrey, M, Klussmann, S, Fliegert, F

“…NOX‐A12 is a PEGylated mirror‐image oligonucleotide (a so‐called Spiegelmer) that binds to CXCL12 (stromal cell–derived factor‐1, SDF‐1) with high affinity…”
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A novel CGRP‐neutralizing Spiegelmer attenuates neurogenic plasma protein extravasation by Hoehlig, K, Johnson, K W, Pryazhnikov, E, Maasch, C, Clemens‐Smith, A, Purschke, W G, Vauléon, S, Buchner, K, Jarosch, F, Khiroug, L, Vater, A, Klussmann, S

“…Background and Purpose Calcitonin gene‐related peptide (CGRP) plays an important role in the pathology of migraine, and recent clinical trials suggest the…”
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Control of neuronal branching by the death receptor CD95 (Fas Apo-1) by Zuliani, C, Kleber, S, Klussmann, S, Wenger, T, Kenzelmann, M, Schreglmann, N, Martinez, A, del Rio, J A, Soriano, E, Vodrazka, P, Kuner, R, Groene, H-J, Herr, I, Krammer, P H, Martin-Villalba, A

“…The CD95 (Apo-1/Fas)/CD95 ligand (CD95L) system is best characterized as a trigger of apoptosis. Nevertheless, despite broad expression of CD95L and CD95 in…”
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Spiegelmer Inhibition of MCP‐1/CCR2 – Potential as an Adjunct Immunosuppressive Therapy in Transplantation by Kalnins, A., Thomas, M. N., Andrassy, M., Müller, S., Wagner, A., Pratschke, S., Rentsch, M., Klussmann, S., Kauke, T., Angele, M. K., Bazhin, A. V., Fischereder, M., Werner, J., Guba, M., Andrassy, J.

“…The rejection process remains the key unsolved issue after transplantation of disparate tissue. The CC chemokine monocyte chemoattractant protein‐1…”
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The Anti-Ghrelin Spiegelmer NOX-B11-3 Blocks Ghrelin- but not Fasting-Induced Neuronal Activation in the Hypothalamic Arcuate Nucleus by Becskei, C., Bilik, K. U., Klussmann, S., Jarosch, F., Lutz, T. A., Riediger, T.

“…The hypothalamic arcuate nucleus (Arc) is the presumed target site for the orexigenic hormone ghrelin, which is secreted from the stomach during fasting…”
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Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats by Kobelt, P, Helmling, S, Stengel, A, Wlotzka, B, Andresen, V, Klapp, B F, Wiedenmann, B, Klussmann, S, Mönnikes, H

“…Background and aims: Ghrelin, the natural ligand of the growth hormone secretagogue receptor 1a, is the most powerful peripherally active orexigenic agent…”
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High-Affinity RNA as a Recognition Element in a Biosensor by Kleinjung, F, Klussmann, S, Erdmann, V. A, Scheller, F. W, Fürste, J. P, Bier, F. F

“…A biosensor for l-adenosine employing high-affinity RNA as binder is reported. Real-time measurement is obtained using total internal reflection fluorescence…”
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Biostable aptamers with antagonistic properties to the neuropeptide nociceptin/orphanin FQ by Faulhammer, Dirk, Eschgfäller, Bernd, Stark, Sandra, Burgstaller, Petra, Englberger, Werner, Erfurth, Jeannette, Kleinjung, Frank, Rupp, Johanna, Dan Vulcu, Sebastian, Schröder, Werner, Vonhoff, Stefan, Nawrath, Hermann, Gillen, Clemens, Klussmann, Sven

“…The neuropeptide nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the opioid receptor-like 1 (ORL1) receptor, has been shown to play a prominent role…”
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First look at RNA in l-configuration by Vallazza, M., Perbandt, M., Klussmann, S., Rypniewski, W., Einspahr, H. M., Erdmann, V. A., Betzel, Ch

“…Nucleic acid molecules in the mirror image or l‐configuration are unknown in nature and are extraordinarily resistant to biological degradation. The…”
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Fluorine-18- and iodine-125-labelling of spiegelmers by Kuhnast, B., Klussmann, S., Hinnen, F., Boisgard, R., Rousseau, B., Fürste, J. P., Tavitian, B., Dollé, F.

“…Spiegelmers are high‐affinity l‐enantiomeric oligonucleotide ligands (aptamers) that display high resistance to enzymatic degradation compared to…”
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A New Class of Spiegelmers Containing 2′-Fluoro-nucleotides by Helmling, S., Moyroud, E., Schroeder, W., Roehl, I., Kleinjung, F., Stark, S., Bahrenberg, G., Gillen, C., Klussmann, S., Vonhoff, S.

“…Synthesis of 2′-fluoro-nucleosides from L-arabinose in order to perform the synthesis of 2′-fluoro-Spiegelmers binding to a neuropeptide…”
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Modified Nucleoside Triphosphates: Synthesis and Applications for RNA In Vitro Selection by Schoetzau, Th, Langner, J., Moyroud, E., Röhl, I., Klussmann, S., Vonhoff, S.

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Chemically-assisted ion-beam etching of (AlGa)As/GaAs : lattice damage and removal by in-situ Cl2 treatment by DALEIDEN, J, KIEFER, R, KLUSSMANN, S, KUNZER, M, MANZ, C, WAILHER, M, BRAUNSTEIN, J, WEIMANN, G

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Spiegelmers: Biostable Aptamers by Eulberg, Dirk, Klussmann, Sven

“…Not from this world: Mirror‐image nucleic acids are made of L‐nucleotides instead of natural D‐nucleotides. Just like natural D‐nucleic acids, single‐stranded…”
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Chemically-assisted ion-beam etching of (AlGa)As/GaAs: lattice damage and removal by in-situ Cl 2 treatment by Daleiden, J, Kiefer, R, Klußmann, S, Kunzer, M, Manz, C, Wailher, M, Braunstein, J, Weimann, G

“…We evaluated the lattice damage in Al 0.4Ga 0.6As/GaAs Single Quantum Well (SQW) structures caused by Chemically-Assisted Ion-Beam Etching (CAIBE) in…”
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Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma by Kleber, Susanne, Sancho-Martinez, Ignacio, Wiestler, Benedict, Beisel, Alexandra, Gieffers, Christian, Hill, Oliver, Thiemann, Meinolf, Mueller, Wolf, Sykora, Jaromir, Kuhn, Andreas, Schreglmann, Nina, Letellier, Elisabeth, Zuliani, Cecilia, Klussmann, Stefan, Teodorczyk, Marcin, Gröne, Hermann-Josef, Ganten, Tom M., Sültmann, Holger, Tüttenberg, Jochen, von Deimling, Andreas, Regnier-Vigouroux, Anne, Herold-Mende, Christel, Martin-Villalba, Ana

“…Invasion of surrounding brain tissue by isolated tumor cells represents one of the main obstacles to a curative therapy of glioblastoma multiforme. Here we…”
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CD95-Ligand on Peripheral Myeloid Cells Activates Syk Kinase to Trigger Their Recruitment to the Inflammatory Site by Letellier, Elisabeth, Kumar, Sachin, Sancho-Martinez, Ignacio, Krauth, Stefanie, Funke-Kaiser, Anne, Laudenklos, Sabrina, Konecki, Katrin, Klussmann, Stefan, Corsini, Nina S., Kleber, Susanne, Drost, Natalia, Neumann, Andreas, Lévi-Strauss, Matthieu, Brors, Benedikt, Gretz, Norbert, Edler, Lutz, Fischer, Carmen, Hill, Oliver, Thiemann, Meinolf, Biglari, Bahram, Karray, Saoussen, Martin-Villalba, Ana

“…Injury to the central nervous system initiates an uncontrolled inflammatory response that results in both tissue repair and destruction. Here, we showed that,…”
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Development of an automated in vitro selection protocol to obtain RNA-based aptamers: identification of a biostable substance P antagonist by Eulberg, Dirk, Buchner, Klaus, Maasch, Christian, Klussmann, Sven

“…We have developed an automated SELEX (Systematic Evolution of Ligands by EXponential Enrichment) process that allows the execution of in vitro selection cycles…”
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Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: tailored-SELEX by Vater, Axel, Jarosch, Florian, Buchner, Klaus, Klussmann, Sven

“…We developed an integrated method to identify aptamers with only 10 fixed nucleotides through ligation and removal of primer binding sites within the…”
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