Search Results - "KLUMP, H"

Impact of bulge loop size on DNA triplet repeat domains: Implications for DNA repair and expansion by Völker, Jens, Plum, G. Eric, Gindikin, Vera, Klump, Horst H., Breslauer, Kenneth J.

“…ABSTRACT Repetitive DNA sequences exhibit complex structural and energy landscapes, populated by metastable, noncanonical states, that favor expansion and…”
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Development of patient-specific hematopoietic stem and progenitor cell grafts from pluripotent stem cells, in vitro by Klump, H, Teichweyde, N, Meyer, C, Horn, P A

“…Pluripotent stem cells hold great promise for future applications in many areas of regenerative medicine. Their defining property of differentiation towards…”
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DNA energy landscapes via calorimetric detection of microstate ensembles of metastable macrostates and triplet repeat diseases by Völker, Jens, Klump, Horst H, Breslauer, Kenneth J

“…Biopolymers exhibit rough energy landscapes, thereby allowing biological processes to access a broad range of kinetic and thermodynamic states. In contrast to…”
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Conformational Energetics of Stable and Metastable States Formed by DNA Triplet Repeat Oligonucleotides: Implications for Triplet Expansion Diseases by Völker, J., Makube, N., Plum, G. E., Klump, H. H., Breslauer, K. J.

“…We have embedded the hexameric triplet repeats (CAG)6and (CTG)6between two (GC)3domains to produce two 30-mer hairpins with the sequences d[(GC)3(CAG)6(GC)3]…”
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DNA Metastability and Biological Regulation:  Conformational Dynamics of Metastable Ω-DNA Bulge Loops by Völker, Jens, Klump, Horst H, Breslauer, Kenneth J

“…Dynamic interchange between DNA conformations, including metastable states, can be of importance to biological function. In this study, we use a combination of…”
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The energetics of i-DNA tetraplex structures formed intermolecularly by d(TC5) and intramolecularly by d[(C5T3)3C5] by Völker, Jens, Klump, Horst H., Breslauer, Kenneth J.

“…Cytosine‐rich DNA at low pH adopts an antiparallel tetraplex structure via the intercalation of two partially protonated, parallel stranded duplexes. This…”
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Exploring the energy landscape of the genetic code by Klump, H.H.

“…New insights into the arrangement of the genetic code table, based on the analysis of the physico-chemical properties of its molecular constituents, are…”
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Self-inactivating retroviral vectors with improved RNA processing by KRAUNUS, J, SCHAUMANN, D. H. S, BAUM, C, MEYER, J, MODLICH, U, FEHSE, B, BRANDENBURG, G, VON LAER, D, KLUMP, H, SCHAMBACH, A, BOHNE, J

“…Three RNA features have been identified that elevate retroviral transgene expression: an intron in the 5' untranslated region (5'UTR), the absence of aberrant…”
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Non-destructive NIR-FT-Raman spectroscopy of plant and animal tissues, of food and works of art by Schrader, B, Schulz, H, Andreev, G.N, Klump, H.H, Sawatzki, J

“…Just after the discovery of Raman spectroscopy in 1928, it became evident that fluorescence with a quantum yield of several orders of magnitude higher than…”
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From quadruplex to helix and back: Meta-stable states can move through a cycle of conformational changes by Mills, M., Mergny, J.L., Klump, H.H.

“…Strand displacement cycles can be driven by sequential addition of short oligonucleotide sequences. Successive inter- and intra-molecular interactions based on…”
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Intercalation into the DNA double helix and in vivo biological activity of water-soluble planar [Pt(diimine)( N, N-dihydroxyethyl- N′-benzoylthioureato)] +Cl − complexes: A study of their thermal stability, their CD spectra and their gel mobility by Wu, Yu-Shan, Koch, Klaus R., Abratt, Valerie R., Klump, Horst H.

“…The interaction of newly synthesised water-soluble planar complexes of general structure [Pt(diimine)( N, N-dihydroxyethyl- N′-benzoylthioureato)] +Cl − with…”
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Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy by KLUMP, H, SCHIEDLMEIER, B, VOGT, B, RYAN, M, OSTERTAG, W, BAUM, C

“…Retroviral vector-mediated expression of the homeoboxgene, HoxB4, in hematopoietic cells has been reported to mediate a benign expansion of gene-modified…”
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Communication between Noncontacting Macromolecules by Völker, Jens, Klump, Horst H., Breslauer, Kenneth J.

“…We present a quantitative experimental demonstration of solventmediated communication between noncontacting biopolymers. We show that changes in the activity…”
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Electrostatic effects in DNA triple helices by Völker, J, Klump, H H

“…Electrostatic effects dominate many aspects of nucleic acid behavior in a sequence independent manner. Sequence dependent electrostatic effects are introduced…”
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Progress in designing nucleic acid structures and fine-tuning their interactions by Klump, H.H., Chauhan, M., Mills, M., Lin, C.

“…The prediction of the structure of biological macromolecules at the atomic level and the design of new meta-stable structures and secondary interactions are…”
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Circular dichroism as a means to follow DNA gymnastics: on the shoulders of giants by Mills, M, Lin, C, Chauhan, M, Klump, H H

“…This is the first report of DNA stem-loops self-assembled by 'foot-loop' interactions into either two-dimensional strings or three-dimensional spirals,…”
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Protein thermostability above 100°C: A key role for ionic interactions by Vetriani, Costantino, Maeder, Dennis L., Tolliday, Nicola, Yip, Kitty S.-P., Stillman, Timothy J., Britton, K. Linda, Rice, David W., Klump, Horst H., Robb, Frank T.

“…The discovery of hyperthermophilic microorganisms and the analysis of hyperthermostable enzymes has established the fact that multisubunit enzymes can survive…”
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Conformational stability of pGEX‐expressed Schistosoma japonicum glutathione S‐transferase: A detoxification enzyme and fusion‐protein affinity tag by Kaplan, Warren, Erhardt, Julija, Sluis‐Cremer, Nicolas, Dirr, Heini, Hüsler, Paul, Klump, Horst

“…A glutathione S‐transferase (SJ26GST) from Schistosoma japonicum, which functions in the parasite's Phase II detoxification pathway, is expressed by the…”
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Kinetic and physical characterisation of recombinant wild-type and mutant human protoporphyrinogen oxidases by Maneli, Mbulelo H., Corrigall, Anne V., Klump, Horst H., Davids, Lester M., Kirsch, Ralph E., Meissner, Peter N.

“…The effects of various protoporphyrinogen oxidase (PPOX) mutations responsible for variegate porphyria (VP), the roles of the arginine-59 residue and the…”
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Chemical Modification of the Third Strand:  Differential Effects on Purine and Pyrimidine Triple Helix Formation by Mills, Martin, Arimondo, Paola B, Lacroix, Laurent, Garestier, Thérèse, Klump, Horst, Mergny, Jean-Louis

“…DNA triple helices offer exciting perspectives toward oligonucleotide-directed control of gene expression. Oligonucleotide analogues are routinely used with…”
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