Search Results - "KLIMEŠ, I."

Concerted action of leptin in regulation of fatty acid oxidation in skeletal muscle and liver by Wein, S, Ukropec, J, Gasperíková, D, Klimes, I, Seböková, E

“…Central action of leptin on food intake and energy expenditure is integrated with leptin's peripheral action modulating the fatty acid and glucose metabolism…”
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Iodine deficiency in vegetarians and vegans by Krajcovicová-Kudlácková, M, Bucková, K, Klimes, I, Seboková, E

“…Iodine content in food of plant origin is lower in comparison with that of animal origin due to a low iodine concentration in soil. Urinary iodine excretion…”
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Neonatal hypoglycemia, early-onset diabetes and hypopituitarism due to the mutation in EIF2S3 gene causing MEHMO syndrome by Stanik, J, Skopkova, M, Stanikova, D, Brennerova, K, Barak, L, Ticha, L, Hornova, J, Klimes, I, Gasperikova, D

“…Recently, the genetic cause of several syndromic forms of glycemia dysregulation has been described. One of them, MEHMO syndrome, is a rare X-linked syndrome…”
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High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail by Ukropec, J, Radikova, Z, Huckova, M, Koska, J, Kocan, A, Sebokova, E, Drobna, B, Trnovec, T, Susienkova, K, Labudova, V, Gasperikova, D, Langer, P, Klimes, I

“…Aims/hypothesis A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between…”
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The molecular genetic background of familial hypercholesterolemia: data from the Slovak nation-wide survey by Gabčová, D, Vohnout, B, Staníková, D, Hučková, M, Kadurová, M, Debreová, M, Kozárová, M, Fábryová, Ľ, Staník, J, Klimeš, I, Rašlová, K, Gašperiková, D

“…Familial hypercholesterolemia (FH) is most frequently caused by LDLR or APOB mutations. Therefore, the aim of our study was to examine the genetic background…”
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Sulfonylurea vs insulin therapy in individuals with sulfonylurea‐sensitive permanent neonatal diabetes mellitus, attributable to a KCNJ11 mutation, and poor glycaemic control by Stanik, J., Dankovcikova, A., Barak, L., Skopkova, M., Palko, M., Divinec, J., Klimes, I., Gasperikova, D.

“…Background Therapy with sulfonylurea is preferable to insulin in the majority of individuals with KCNJ11 mutations, but not all of these people achieve target…”
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Impaired Endothelial Function of Thoracic Aorta in Hereditary Hypertriglyceridemic Rats by TÖRÖK, J., BABÁL, P., MATUŠKOVÁ, J., LUPTÁK, I., KLIMEŠ, I., ŠIMKO, F.

“…: Objective—Hereditary hypertriglyceridemia (hHTG) in rats was found to be associated with metabolic abnormalities and elevation of blood pressure. There is…”
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A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes by Thanabalasingham, G., Shah, N., Vaxillaire, M., Hansen, T., Tuomi, T., Gašperíková, D., Szopa, M., Tjora, E., James, T. J., Kokko, P., Loiseleur, F., Andersson, E., Gaget, S., Isomaa, B., Nowak, N., Raeder, H., Stanik, J., Njolstad, P. R., Malecki, M. T., Klimes, I., Groop, L., Pedersen, O., Froguel, P., McCarthy, M. I., Gloyn, A. L., Owen, K. R.

“…Aims/hypothesis An accurate molecular diagnosis of diabetes subtype confers clinical benefits; however, many individuals with monogenic diabetes remain…”
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Mapping of genetic determinants of the sympathoneural response to stress by Klimes, I, Weston, K, Gasperikova, D, Kovacs, P, Kvetnansky, R, Jezova, D, Dixon, R, Thompson, J. R, Sebokova, E, Samani, N. J

“…1 Diabetes and Nutrition Research Laboratory, Slovak Academy of Sciences, Bratislava, Slovakia 2 Stress Research Laboratory, Slovak Academy of Sciences,…”
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Insulin Resistance in the Hereditary Hypertriglyceridemic Rat Is Associated with an Impairment of Δ-6 Desaturase Expression in Liver by GAŠPERÍKOVÁ, D., DEMCÁKOVÁ, E., UKROPEC, J., KLIMEŠ, I., ŠEBÖKOVÁ, E.

“…: Our previous studies have shown that insulin resistance (IR) in the hereditary hypertriglyceridemic (hHTg) rat is accompanied by a specific fatty acid (FA)…”
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Insulin sensitivity indices: a proposal of cut-off points for simple identification of insulin-resistant subjects by Radikova, Z, Koska, J, Huckova, M, Ksinantova, L, Imrich, R, Vigas, M, Trnovec, T, Langer, P, Sebokova, E, Klimes, I

“…Demanding measurement of insulin sensitivity using clamp methods does not simplify the identification of insulin resistant subjects in the general population…”
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Molecular analysis of genes involved in lipoprotein lipase deficiency in Slovak patients with familial chylomicronemia by Gabcova, D, Stanikova, D, Huckova, M, Bzduch, V, Stanik, J, Klimes, I, Raslova, K, Gasperikova, D

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Lipids and Insulin Resistance: What We've Learned at the Fourth International Smolenice Symposium by RAVUSSIN, E., KLIMEŠ, I., ŠEBÖKOVÁ, E., HOWARD, B. V.

“…: A summary of the Fourth International Smolenice Symposium on Lipids and Insulin Resistance focusing on “The Role of Fatty Acid Metabolism and Fuel…”
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Molecular and Cellular Determinants of Triglyceride Availability by Seböková, E, Klimes, I

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DNA diagnostics of familial hypercholesterolemia: Slovak experience by Balaziova, D, Vohnout, B, Huckova, M, Stanikova, D, Stanik, J, Klimes, I, Raslova, K, Gasperikova, D

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Circulatory and adipose tissue leptin and adiponectin in relationship to resting energy expenditure in patients with chronic obstructive pulmonary disease by Brúsik, M, Ukropec, J, Joppa, P, Ukropcová, B, Skyba, P, Baláž, M, Pobeha, P, Kurdiová, T, Klimeš, I, Tkáč, I, Gašperíková, D, Tkáčová, R

“…Increases in resting energy expenditure (REE) likely contribute to weight loss in various chronic diseases. In chronic obstructive pulmonary disease (COPD),…”
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Prevalence of DFNB1 mutations among cochlear implant users in Slovakia and its clinical implications by Varga, L., Mašindová, I., Hučková, M., Kabátová, Z., Gašperíková, D., Klimeš, I., Profant, M.

“…Hereditary etiology plays an important role in bilateral profound deafness as a main indication for cochlear implantation. Mutations in DFNB1 locus account for…”
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Nutrient Sensing, Leptin and Insulin Action by Ukropec, J., Šeböková, E., Klimeš, I.

“…The glucose-fatty acid cycle as proposed four decades ago by Randle suggests that insulin resistance develops in consequence of alterations of the metabolic…”
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An Increase in Peroxisomal Fatty Acid Oxidation Is Not Sufficient to Prevent Tissue Lipid Accumulation in hHTg Rats by UKROPEC, J., KLIMEŠ, I., GAŠPERÍKOVÁ, D., DEMCÁKOVÁ, E., DREVON, C. A., RESELAND, J. E., ŠEBÖKOVÁ, E.

“…: We observed earlier that increased skeletal muscle lipid content in the hereditary hypertriglyceridemic (hHTg) rat is accompanied by a decline in plasma…”
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Improving mental health through parenting programmes: block randomised controlled trial by Patterson, J, Barlow, J, Mockford, C, Klimes, I, Pyper, C, Stewart-Brown, S

“…Aims: To assess the effectiveness of a parenting programme, delivered by health visitors in primary care, in improving the mental health of children and their…”
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