Search Results - "KLIGERMAN, M M"

Use of radiation with or without WR-2721 in advanced rectal cancer by Liu, T, Liu, Y, He, S, Zhang, Z, Kligerman, M M

“…One hundred patients with inoperable, unresectable, or recurrent adenocarcinoma of the rectum were stratified and randomized to WR-2721 plus radiation therapy…”
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Integrating Laser Surface Mapping with CBCT for Enhanced Decision Support from ML Guided Resimulation Predictions by Shang, S., Evans, G., Kligerman, M., Shang, M., Williams, T.R., Shang, C.Y.

“…The study's primary objective is to evaluate the comparability of C-RAD Surface Mapping Images (SMI) scores with traditional CT Surface Mapping (CTSM) scores…”
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Decreased acute toxicity by using midline mucosa-sparing blocks during radiation therapy for carcinoma of the oral cavity, oropharynx, and nasopharynx by Perch, S J, Machtay, M, Markiewicz, D A, Kligerman, M M

“…To determine whether midline mucosa-sparing blocks (MSBs) protecting the aerodigestive tract can statistically significantly reduce acute toxicity during…”
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Preliminary investigation of symptom distress in the head and neck patient population: validation of a measurement instrument by Jones, Heather A, Hershock, Diane, Machtay, Mitchell, Chalian, Ara A, Weber, Randal S, Weinstein, Gregory S, Schumacher, Karen, Kligerman, Morton M, Berlin, Jessie A, Rosenthal, David I

“…Observations indicate that the acute toxicity of chemoradiation for squamous cell carcinoma (SCC) of the head and neck is not the same as that which occurs…”
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Variation in parotid gland size, configuration, and anatomic relations by Medbery, Robbie, Yousem, David M, Needham, Michael F, Kligerman, Morton M

“…Purpose: To examine the variation in the anatomy of parotid glands discerned by magnetic resonance imaging. Methods: Head and neck magnetic resonance scans of…”
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Final report of a pilot trial of accelerated radiotherapy plus concurrent 96-hour infusional paclitaxel for locally advanced head and neck cancer by Bucci, Mary K, Rosenthal, David I, Hershock, Diane, Metz, James, Devine, Pamela, Kligerman, Morton M, Machtay, Mitchell

“…Recent data show that accelerated radiotherapy (XRT) improves local-regional control (LRC) over standard-fractionation XRT. Concurrent chemoradiotherapy…”
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WR-2721 protects against the hematologic toxicity of cyclophosphamide: a controlled phase II trial by Glover, D, Glick, J H, Weiler, C, Hurowitz, S, Kligerman, M M

“…WR-2721 S-2-(3-aminopropylamino) ethyl phosphorothioic acid, is an organic thiophosphate compound that in the animal model selectively protects against the…”
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Radiotherapy with 6-megavolt photons for early glottic carcinoma: Potential impact of extension to the posterior vocal cord by Lee, Jason H., Machtay, Mitchell, McKenna, Michael G., Weinstein, Gregory S., Markiewicz, Deborah A., Krisch, Robert E., Kligerman, Morton M.

“…Purpose: Radiation therapy has a high success rate in the treatment of early glottic carcinoma. Excellent outcomes have been reported from centers using…”
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A prospective study of treatment techniques to minimize the volume of pelvic small bowel with reduction of acute and late effects associated with pelvic irradiation by Gallagher, M J, Brereton, H D, Rostock, R A, Zero, J M, Zekoski, D A, Poyss, L F, Richter, M P, Kligerman, M M

“…The volume, distribution, and mobility of opacified pelvic small bowel (PSB) were determined by fluoroscopy and orthogonal radiographs in 150 consecutive…”
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Gastrointestinal hemorrhage complicating aspirin therapy in acute Kawasaki disease by Matsubara, Tomoyo, Mason, Wilbert, Kashani, Iraj A., Kligerman, Morton, Burns, Jane C.

“…Although gastrointestinal hemorrhage is a well-recognized complication of aspirin therapy, this side effect has not been previously reported in patients with…”
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Evaluation of multileaf collimator design for a photon beam by Galvin, J M, Smith, A R, Moeller, R D, Goodman, R L, Powlis, W D, Rubenstein, J, Solin, L J, Michael, B, Needham, M, Huntzinger, C J

“…Various aspects of multileaf collimator (MLC) design are examined relative to clinical requirements. The characteristics studied included: (a) irregular field…”
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Interim analysis of a randomized trial of radiation therapy of rectal cancer with/without WR-2721 by Kligerman, M M, Liu, T, Liu, Y, Scheffler, B, He, S, Zhang, Z

“…The objectives of this randomized trial are to define the maximum tolerated dose of radiation therapy, at curative dose levels, that can be delivered following…”
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Final report on phase I trial of WR-2721 before protracted fractionated radiation therapy by Kligerman, M M, Turrisi, 3rd, A T, Urtasun, R C, Norfleet, A L, Phillips, T L, Barkley, T, Rubin, P

“…This is the final report of the Phase I Protocol for the initial clinical study of Multiple Dose WR-2721 with radiotherapy (RTOG 80-02). The essential object…”
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Hypocalcemia and inhibition of parathyroid hormone secretion after administration of WR-2721 (a radioprotective and chemoprotective agent) by Glover, D, Riley, L, Carmichael, K, Spar, B, Glick, J, Kligerman, M M, Agus, Z S, Slatopolsky, E, Attie, M, Goldfarb, S

“…We investigated the causes of the hypocalcemia associated with WR-2721, an investigational drug that protects normal tissues against the toxic effects of…”
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Toxicity of WR-2721 administered in single and multiple doses by Kligerman, M M, Glover, D J, Turrisi, A T, Norfleet, A L, Yuhas, J M, Coia, L R, Simone, C, Glick, J H, Goodman, R L

“…Two hundred forty-three patients have received WR-2721 in Phase I-II studies. Separate studies were conducted in which patients with advanced malignancies…”
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Association of Neighborhood Design and Recreation Environment Variables with Physical Activity and Body Mass Index in Adolescents by Kligerman, Morton, Sallis, James F., Ryan, Sherry, Frank, Lawrence D., Nader, Philip R.

“…Purpose. To examine associations of neighborhood walkability and recreation environment variables with physical activity in adolescents. Methods. The…”
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Pharmacokinetics of WR-2721 by Shaw, L M, Glover, D, Turrisi, A, Brown, D Q, Bonner, H S, Norfleet, A L, Weiler, C, Glick, J H, Kligerman, M M

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Diagnostic imaging aids to head and neck radiation oncology by Tamler, B J, Kligerman, M M

“…Tumors of the head and neck are primary sites for radiation treatment. In combination with surgery, the role of radiation is further expanded; however,…”
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Human pharmacokinetics of WR-2721 by Shaw, L M, Turrisi, A T, Glover, D J, Bonner, H S, Norfleet, A L, Weiler, C, Kligerman, M M

“…The pharmacokinetic properties of WR-2721 were investigated in 13 cancer patients given a 150 mg/M2 intravenous bolus dose of the drug. An average plasma…”
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Factors Influencing the Oxidation of the Radioprotector WR-1065 by Tahsildar, Hassan I., Biaglow, John E., Kligerman, Morton M., Varnes, Marie E.

“…N-(2-Mercaptoethyl)-1,3-diaminopropane (WR-1065) is the free thiol form of the radio- and chemoprotector S-2-(aminopropylamino)ethylphosphorothioic acid…”
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