Search Results - "KLEPPER, Mariska"

The FCGR3A 158 V/V-genotype is associated with decreased survival of renal allografts with chronic active antibody-mediated rejection by Litjens, Nicolle, Peeters, Annemiek, Gestel, Judith Kal-van, Klepper, Mariska, Betjes, Michiel

“…Natural killer (NK) cells express the Fc-gamma receptor CD16 ( FCGR3A ) and could therefore mediate renal endothelial cell damage in cases of chronic-active…”
Get full text

Older age is associated with a distinct and marked reduction of functionality of both alloreactive CD4+ and CD8+ T cells by Litjens, Nicolle H R, van der List, Amy C J, Klepper, Mariska, Reijerkerk, Derek, Prevoo, Fréderique, Betjes, Michiel G H

“…Older recipient age is associated with a significant decreased risk for rejection after kidney transplantation which is incompletely understood. In a…”
Get full text

Increased CD16 expression on NK cells is indicative of antibody-dependent cell-mediated cytotoxicity in chronic-active antibody-mediated rejection by Sablik, Kasia A., Litjens, Nicolle H.R., Klepper, Mariska, Betjes, Michiel G.H.

“…Chronic-active antibody mediated rejection (c-aABMR) contributes significantly to late renal allograft failure. The antibodies directed against donor-derived…”
Get full text

Expression of Senescence Marker TIGIT Identifies Polyfunctional Donor-Reactive CD4+ T Cells Preferentially Lost After Kidney Transplantation by van der List, Amy C J, Litjens, Nicolle H R, Klepper, Mariska, Betjes, Michiel G H

“…Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decreased risk for acute rejection in the years following kidney…”
Get full text

Single-Cell RNA Sequencing of Donor-Reactive T Cells Reveals Role of Apoptosis in Donor-Specific Hyporesponsiveness of Kidney Transplant Recipients by van der List, Amy C. J., Litjens, Nicolle H. R., Brouwer, Rutger W. W., Klepper, Mariska, den Dekker, Alexander T., van Ijcken, Wilfred F. J., Betjes, Michiel G. H.

“…After kidney transplantation (KT), donor-specific hyporesponsiveness (DSH) of recipient T cells develops over time. Recently, apoptosis was identified as a…”
Get full text

Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation by Dedeoglu, Burç, Meijers, Ruud W J, Klepper, Mariska, Hesselink, Dennis A, Baan, Carla C, Litjens, Nicolle H R, Betjes, Michiel G H

“…End-stage renal disease patients have a dysfunctional, prematurely aged peripheral T-cell system. Here we hypothesized that the degree of premature T-cell…”
Get full text

The Number of Donor-Specific IL-21 Producing Cells Before and After Transplantation Predicts Kidney Graft Rejection by van Besouw, Nicole M, Yan, Lin, de Kuiper, Ronella, Klepper, Mariska, Reijerkerk, Derek, Dieterich, Marjolein, Roelen, Dave L, Claas, Frans H J, Clahsen-van Groningen, Marian C, Hesselink, Dennis A, Baan, Carla C

“…Interleukin (IL)-21 supports induction and expansion of CD8 T cells, and can also regulate the differentiation of B cells into antibody-producing plasma cells…”
Get full text

A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation by Betjes, Michiel G H, Langerak, Anton W, Klepper, Mariska, Litjens, Nicolle H R

“…End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was…”
Get full text

Effects of Morbid Obesity and Metabolic Syndrome on the Composition of Circulating Immune Subsets by Wijngaarden, Leontine H., van der Harst, Erwin, Klaassen, René A., Dunkelgrun, Martin, Kuijper, T Martijn, Klepper, Mariska, Ambagtsheer, Gisela, IJzermans, Jan N. M., de Bruin, Ron W. F., Litjens, Nicolle H. R.

“…Morbid obesity is characterized by chronic, low-grade inflammation, which is associated with ‘inflamm-aging’. The presence of metabolic syndrome (MetS) might…”
Get full text

End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8 + T Cell Subsets by Huang, Ling, Betjes, Michiel G H, Klepper, Mariska, Langerak, Anton W, Baan, Carla C, Litjens, Nicolle H R

“…A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease…”
Get full text

A Novel Technique for the Generation of Substantial Numbers of Functional Resident T Cells from Kidney Tissue by Betjes, Michiel G H, Prevoo, Frederique, van den Bosch, Thierry P P, Klepper, Mariska, Litjens, Nicolle H R

“…Studying functionality and antigen-specificity of resident kidney T cells derived from a kidney biopsy is hampered by the lack of sufficient numbers of T cells…”
Get full text

Validation of a Combined Transcriptome and T Cell Receptor Alpha/Beta (TRA/TRB) Repertoire Assay at the Single Cell Level for Paucicellular Samples by Litjens, Nicolle H R, Langerak, Anton W, van der List, Amy C J, Klepper, Mariska, de Bie, Maaike, Azmani, Zakia, den Dekker, Alexander T, Brouwer, Rutger W W, Betjes, Michiel G H, Van IJcken, Wilfred F J

“…Transcriptomics can be combined with TRA and TRB clonotype analysis at the single cell level. The aim of this study was to validate this approach on the ICELL8…”
Get full text

T-Cell Composition of the Lymph Node Is Associated with the Risk for Early Rejection after Renal Transplantation by Dedeoglu, Burç, Litjens, Nicolle H R, de Weerd, Annelies E, Dor, Frank Jmf, Klepper, Mariska, Reijerkerk, Derek, Baan, Carla C, Betjes, Michiel G H

“…The T-cell composition within the lymph node (LN) of end-stage renal disease (ESRD) patients differs from the composition within the circulation. Activation of…”
Get full text

Interleukin-17–producing CD4+ cells home to the graft early after human heart transplantation by van Besouw, Nicole M., PhD, Caliskan, Kadir, MD, PhD, Peeters, Annemiek M.A., BSc, Klepper, Mariska, BSc, Dieterich, Marjolein, BSc, Maat, Lex P.W.M., MD, Weimar, Willem, MD, PhD, Manintveld, Olivier C., MD, PhD, Baan, Carla C., PhD

“…Background Interleukin-17 (IL-17) is regarded as a major effector cytokine with pro-inflammatory actions. It has pleiotropic and environment-specific functions…”
Get full text

pERK-dependent defective TCR-mediated activation of CD4 + T cells in end-stage renal disease patients by Huang, Ling, Litjens, Nicolle H R, Kannegieter, Nynke M, Klepper, Mariska, Baan, Carla C, Betjes, Michiel G H

“…Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs)…”
Get full text

The Effect of the JAK Inhibitor CP-690,550 on Peripheral Immune Parameters in Stable Kidney Allograft Patients by VAN GURP, Evelien A. F. J, SCHOORDIJK-VERSCHOOR, Wenda, KLEPPER, Mariska, KOREVAAR, Sander S, CHAN, Gary, WEIMAR, Willem, BAAN, Carla C

“…CP-690,550 inhibits Janus kinase 3 (JAK3) which mediates signal transduction of receptors of the common gamma-chain cytokines. These cytokines play key roles…”
Get full text

Progressive Loss of Donor-Reactive CD4+ Effector Memory T Cells due to Apoptosis Underlies Donor-Specific Hyporesponsiveness in Stable Renal Transplant Recipients by van der List, Amy C. J., Litjens, Nicolle H. R., Klepper, Mariska, Prevoo, Fréderique, Betjes, Michiel G. H.

“…Abstract Following kidney transplantation, donor-specific hyporesponsiveness (DSH) may develop, defined as a lowered response of alloreactive T cells,…”
Get full text

Polyfunctional donor-reactive T cells are associated with acute T-cell-mediated rejection of the kidney transplant by Litjens, Nicolle H R, van der List, Amy C J, Klepper, Mariska, Prevoo, Fréderique, Boer, Karin, Hesselink, Dennis A, Betjes, Michiel G H

“…Abstract Acute T-cell-mediated rejection (aTCMR) still remains a clinical problem after kidney transplantation despite significant improvements in…”
Get full text

Activated CD4+ T Cells and Highly Differentiated Alloreactive CD4+ T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients by Duizendstra, Aafke A., Knegt, Robert J., Mancham, Shanta, Klepper, Mariska, Roelen, Dave L., Brand‐Schaaf, Simone H., Boor, Patrick P., Doukas, Michail, Man, Robert A., Sprengers, Dave, Peppelenbosch, Maikel P., Betjes, Michiel G. H., Kwekkeboom, Jaap, Litjens, Nicolle H. R.

“…Spontaneous operational tolerance to the allograft develops in a proportion of liver transplantation (LT) recipients weaned off immunosuppressive (IS) drugs…”
Get full text

The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients by Bouvy, Anne P, Klepper, Mariska, Kho, Marcia M L, Boer, Karin, Betjes, Michiel G H, Weimar, Willem, Baan, Carla C

“…To evaluate the influence of induction therapy on Tregs we investigated their origin, kinetics and function in kidney transplant patients after treatment with…”
Get full text