Search Results - "KLEINRIDDERS, ANDRE"

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function by KLEINRIDDERS, André, FERRIS, Heather A, WEIKANG CAI, KAHN, C. Ronald

“…Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed throughout the brain. Insulin acts on these receptors…”
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Untangling the effect of insulin action on brain mitochondria and metabolism by Schell, Mareike, Wardelmann, Kristina, Kleinridders, André

“…The regulation of energy homeostasis is controlled by the brain and, besides requiring high amounts of energy, it relies on functional insulin/insulin‐like…”
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Central nervous pathways of insulin action in the control of metabolism and food intake by Kullmann, Stephanie, Kleinridders, André, Small, Dana M, Fritsche, Andreas, Häring, Hans-Ulrich, Preissl, Hubert, Heni, Martin

“…Insulin acts on the CNS to modulate behaviour and systemic metabolism. Disturbances in brain insulin action represent a possible link between metabolic and…”
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Insulin receptor signaling in normal and insulin-resistant states by Boucher, Jérémie, Kleinridders, André, Kahn, C Ronald

“…In the wake of the worldwide increase in type-2 diabetes, a major focus of research is understanding the signaling pathways impacting this disease. Insulin…”
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Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity by Jais, Alexander, Solas, Maite, Backes, Heiko, Chaurasia, Bhagirath, Kleinridders, André, Theurich, Sebastian, Mauer, Jan, Steculorum, Sophie M., Hampel, Brigitte, Goldau, Julia, Alber, Jens, Förster, Carola Y., Eming, Sabine A., Schwaninger, Markus, Ferrara, Napoleone, Karsenty, Gerard, Brüning, Jens C.

“…High-fat diet (HFD) feeding induces rapid reprogramming of systemic metabolism. Here, we demonstrate that HFD feeding of mice downregulates glucose transporter…”
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Impact of Brain Insulin Signaling on Dopamine Function, Food Intake, Reward, and Emotional Behavior by Kleinridders, André, Pothos, Emmanuel N.

“…Purpose of Review Dietary obesity is primarily attributed to an imbalance between food intake and energy expenditure. Adherence to lifestyle interventions…”
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Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity by Xiao, Xing, Yeghiazaryan, Gagik, Hess, Simon, Klemm, Paul, Sieben, Anna, Kleinridders, André, Morgan, Donald A., Wunderlich, F. Thomas, Rahmouni, Kamal, Kong, Dong, Scammell, Thomas E., Lowell, Bradford B., Kloppenburg, Peter, Brüning, Jens C., Hausen, A. Christine

“…The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here we show orexin receptor type 1 and 2 are…”
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Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation by ENXUAN JING, O'NEILL, Brian T, GIBSON, Bradford W, KAHN, C. Ronald, RARDIN, Matthew J, KLEINRIDDERS, André, ILKEYEVA, Olga R, USSAR, Siegfried, BAIN, James R, LEE, Kevin Y, VERDIN, Eric M, NEWGARD, Christopher B

“…Sirt3 is an NAD(+)-dependent deacetylase that regulates mitochondrial function by targeting metabolic enzymes and proteins. In fasting mice, Sirt3 expression…”
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Insulin resistance in brain alters dopamine turnover and causes behavioral disorders by Kleinridders, Andre, Cai, Weikang, Cappellucci, Laura, Ghazarian, Armen, Collins, William R., Vienberg, Sara G., Pothos, Emmanuel N., Kahn, C. Ronald

“…Significance Both types 1 and 2 diabetes are associated with increased risks of age-related decay in cognitive function and mood disorders, especially…”
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MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity by Kleinridders, André, Schenten, Dominik, Könner, A. Christine, Belgardt, Bengt F., Mauer, Jan, Okamura, Tomoo, Wunderlich, F. Thomas, Medzhitov, Ruslan, Brüning, Jens C.

“…Obesity-associated activation of inflammatory pathways represents a key step in the development of insulin resistance in peripheral organs, partially via…”
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High-fat diet alters N-glycosylation of PTPRJ in murine liver by Ulke, Jannis, Schwedler, Christian, Krüger, Janine, Stein, Vanessa, Geserick, Peter, Kleinridders, André, Kappert, Kai

“…Protein tyrosine phosphatases (PTPs) regulate multiple signaling pathways. Disruption of tyrosine phosphorylation through imbalanced action between protein…”
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Leptin regulation of Hsp60 impacts hypothalamic insulin signaling by Kleinridders, André, Lauritzen, Hans P M M, Ussar, Siegfried, Christensen, Jane H, Mori, Marcelo A, Bross, Peter, Kahn, C Ronald

“…Type 2 diabetes is characterized by insulin resistance and mitochondrial dysfunction in classical target tissues such as muscle, fat, and liver. Using a murine…”
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Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression by Cai, Weikang, Sakaguchi, Masaji, Kleinridders, Andre, Gonzalez-Del Pino, Gonzalo, Dreyfuss, Jonathan M., O’Neill, Brian T., Ramirez, Alfred K., Pan, Hui, Winnay, Jonathon N., Boucher, Jeremie, Eck, Michael J., Kahn, C. Ronald

“…Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate…”
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PTPRJ is a negative regulator of insulin signaling in neuronal cells, impacting protein biosynthesis, and neurite outgrowth by Ulke, Jannis, Chopra, Simran, Kadiri, Otsuware Linda-Josephine, Geserick, Peter, Stein, Vanessa, Cheshmeh, Sahar, Kleinridders, André, Kappert, Kai

“…Central insulin resistance has been linked to the development of neurodegenerative diseases and mood disorders. Various proteins belonging to the enzyme family…”
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Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism? by Castro, José Pedro, Wardelmann, Kristina, Grune, Tilman, Kleinridders, André

“…The brain orchestrates organ function and regulates whole body metabolism by the concerted action of neurons and glia cells in the central nervous system. To…”
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Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function by Boucher, Jeremie, Softic, Samir, El Ouaamari, Abdelfattah, Krumpoch, Megan T, Kleinridders, Andre, Kulkarni, Rohit N, O'Neill, Brian T, Kahn, C Ronald

“…To determine the roles of insulin and insulin-like growth factor 1 (IGF-1) action in adipose tissue, we created mice lacking the insulin receptor (IR), IGF-1…”
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Hemicentin-1 is an essential extracellular matrix component of the dermal–epidermal and myotendinous junctions by Welcker, Daniela, Stein, Cornelia, Feitosa, Natalia Martins, Armistead, Joy, Zhang, Jin-Li, Lütke, Steffen, Kleinridders, Andre, Brüning, Jens C., Eming, Sabine A., Sengle, Gerhard, Niehoff, Anja, Bloch, Wilhelm, Hammerschmidt, Matthias

“…The extracellular matrix architecture is composed of supramolecular fibrillar networks that define tissue specific cellular microenvironments. Hemicentins…”
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ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes by Ussar, Siegfried, Lee, Kevin Y, Dankel, Simon N, Boucher, Jeremie, Haering, Max-Felix, Kleinridders, Andre, Thomou, Thomas, Xue, Ruidan, Macotela, Yazmin, Cypess, Aaron M, Tseng, Yu-Hua, Mellgren, Gunnar, Kahn, C Ronald

“…White, beige, and brown adipocytes are developmentally and functionally distinct but often occur mixed together within individual depots. To target white,…”
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Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain by Wardelmann, Kristina, Blümel, Sabine, Rath, Michaela, Alfine, Eugenia, Chudoba, Chantal, Schell, Mareike, Cai, Weikang, Hauffe, Robert, Warnke, Kathrin, Flore, Tanina, Ritter, Katrin, Weiß, Jürgen, Kahn, C. Ronald, Kleinridders, André

“…Insulin action in the brain controls metabolism and brain function, which is linked to proper mitochondrial function. Conversely, brain insulin resistance…”
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Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis by O'Neill, Brian T, Lee, Kevin Y, Klaus, Katherine, Softic, Samir, Krumpoch, Megan T, Fentz, Joachim, Stanford, Kristin I, Robinson, Matthew M, Cai, Weikang, Kleinridders, Andre, Pereira, Renata O, Hirshman, Michael F, Abel, E Dale, Accili, Domenico, Goodyear, Laurie J, Nair, K Sreekumaran, Kahn, C Ronald

“…Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but…”
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