Search Results - "KLEINIG, Tim"
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Exploring the relationship between ischemic core volume and clinical outcomes after thrombectomy or thrombolysis
Published in Neurology (16-07-2019)“…OBJECTIVETo assess whether complete reperfusion after IV thrombolysis (IVT-R) would result in similar clinical outcomes compared to complete reperfusion after…”
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Machine learning segmentation of core and penumbra from acute stroke CT perfusion data
Published in Frontiers in neurology (23-02-2023)“…Computed tomography perfusion (CTP) imaging is widely used in cases of suspected acute ischemic stroke to positively identify ischemia and assess suitability…”
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Cost-effectiveness of targeted thrombolytic therapy for stroke patients using multi-modal CT compared to usual practice
Published in PloS one (23-10-2018)“…The use of multimodal computed tomography imaging (MMCT) in routine clinical assessment of stroke patients improves the identification of patients with large…”
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Optimal CT perfusion thresholds for core and penumbra in acute posterior circulation infarction
Published in Frontiers in neurology (09-02-2023)“…At least 20% of strokes involve the posterior circulation (PC). Compared to the anterior circulation, posterior circulation infarction (POCI) are frequently…”
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A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND)
Published in International journal of stroke (01-01-2012)“…Background and hypothesis Thrombolytic therapy with tissue plasminogen activator is effective for acute ischaemic stroke within 4·5 h of onset. Patients who…”
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Assessing the Relative Value of CT Perfusion Compared to Non-contrast CT and CT Angiography in Prognosticating Reperfusion-Eligible Acute Ischemic Stroke Patients
Published in Frontiers in neurology (09-09-2021)“…In the present study we sought to measure the relative statistical value of various multimodal CT protocols at identifying treatment responsiveness in patients…”
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Ischemic core thresholds change with time to reperfusion: A case control study
Published in Annals of neurology (01-12-2017)“…Introduction We aimed to identify whether acute ischemic stroke patients with known complete reperfusion after thrombectomy had the same baseline computed…”
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Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results
Published in JAMA neurology (01-06-2019)“…Extracranial carotid and vertebral artery dissection is an important cause of stroke, particularly in younger individuals. In some but not all observational…”
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Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial
Published in Lancet neurology (01-04-2015)“…Summary Background Extracranial carotid and vertebral artery dissection is an important cause of stroke, especially in young people. In some observational…”
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Evaluation of a CTA-Triage Based Transient Ischemic Attack Service: A Retrospective Single Center Cohort Study
Published in Journal of stroke and cerebrovascular diseases (01-12-2018)“…We designed a computed tomography angiography (CTA)-based algorithm for patients presenting to hospital with a transient ischemic attack (TIA) which identified…”
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Validating a Predictive Model of Acute Advanced Imaging Biomarkers in Ischemic Stroke
Published in Stroke (1970) (01-03-2017)“…BACKGROUND AND PURPOSE—Advanced imaging to identify tissue pathophysiology may provide more accurate prognostication than the clinical measures used currently…”
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Ultra-Long Transfers for Endovascular Thrombectomy—Mission Impossible?: The Australia-New Zealand Experience
Published in Stroke (1970) (01-01-2023)“…Endovascular thrombectomy (EVT) access in remote areas is limited. Preliminary data suggest that long distance transfers for EVT may be beneficial; however,…”
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The role of the basal ganglia in data processing
Published in Medical hypotheses (2008)“…Summary Complex cerebral activities are likely to be composed of massively repeated simple data processing tasks since the cortical data processing unit, the…”
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Stroke Epidemiology in an Australian Rural Cohort (SEARCH)
Published in International journal of stroke (01-02-2017)“…Background Stroke rates in Australia and New Zealand have been declining since 1990 but all studies have been completed in large urban centers. Aim We report…”
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Too good to treat? ischemic stroke patients with small computed tomography perfusion lesions may not benefit from thrombolysis
Published in Annals of neurology (01-08-2016)“…Objective Although commonly used in clinical practice, there remains much uncertainty about whether perfusion computed tomography (CTP) should be used to…”
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A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial
Published in International journal of stroke (01-08-2024)“…Background: Almost half of acute ischemic stroke patients present with mild symptoms and there are large practice variations in their treatment globally…”
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Embedding Best Evidence Cultural and Clinical Stroke Care in Training
Published in Heart, lung & circulation (2019)Get full text
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Stroke Incidence and Outcomes in Indigenous Australians
Published in Heart, lung & circulation (2019)Get full text
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Ischaemic stroke among young people aged 15 to 50 years in Adelaide, South Australia
Published in Medical journal of Australia (21-11-2011)“…Objectives: To report risk factors, aetiology and neuroimaging features among a large series of young Australian patients who were admitted to hospital for a…”
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A population‐based study of thrombolysis for acute stroke in South Australia
Published in Medical journal of Australia (01-04-2011)Get full text
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